A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome.
Lau KA, Yang X, Rioult-Pedotti MS, Tang S, Appleman M, Zhang J, Tian Y, Marino C, Yao M, Jiang Q, Tsuda AC, Huang YA, Cao C, Marshall J.
Lau KA, et al.
Prog Neurobiol. 2023 Nov;230:102513. doi: 10.1016/j.pneurobio.2023.102513. Epub 2023 Aug 1.
Prog Neurobiol. 2023.
PMID: 37536482
We demonstrate that CN2097, a peptidomimetic compound that binds postsynaptic density protein-95 (PSD-95), a TrkB associated scaffolding protein, mitigates deficits in PLC-CaMKII and PI3K/mTOR pathways to restore synaptic plasticity and learning. Administration of CN2097 facilita …
We demonstrate that CN2097, a peptidomimetic compound that binds postsynaptic density protein-95 (PSD-95), a TrkB associated scaffolding pro …