Novel CDK19-Targeted Radiotracers: A Potential Design Strategy to Improve the Pharmacokinetics and Tumor Uptake.
Dai D, Yu J, Gou W, Yang S, Li Y, Wang Z, Yang Z, Huang T, Li P, Zhu T, Hou W, Zhao Y, Xu W, Li Y.
Dai D, et al. Among authors: huang t.
J Med Chem. 2024 Apr 25;67(8):6726-6737. doi: 10.1021/acs.jmedchem.4c00281. Epub 2024 Apr 3.
J Med Chem. 2024.
PMID: 38570733
The ligand (68)Ga-10c demonstrated high absorption in tumor 5 min after injection and sustains long-term imaging within 3 h. Furthermore, (68)Ga-10c exhibited slow clearance within the tumor and was predominantly metabolized in both the liver and kidneys, showing the poten …
The ligand (68)Ga-10c demonstrated high absorption in tumor 5 min after injection and sustains long-term imaging within 3 h. Furtherm …