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A chemical corrector modifies the channel function of F508del-CFTR.
Kim Chiaw P, Wellhauser L, Huan LJ, Ramjeesingh M, Bear CE. Kim Chiaw P, et al. Among authors: huan lj. Mol Pharmacol. 2010 Sep;78(3):411-8. doi: 10.1124/mol.110.065862. Epub 2010 May 25. Mol Pharmacol. 2010. PMID: 20501743
To test this hypothesis, we assessed the effect of VRT-325 addition on the channel activity of F508del-CFTR after its surface expression had been "rescued" by low temperature. It is noteworthy that short-term pretreatment with VRT-325 [but not with an inactive analog, 4-hy …
To test this hypothesis, we assessed the effect of VRT-325 addition on the channel activity of F508del-CFTR after its surface expression had …