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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Cohen HY, et al. Among authors: howitz kt. Science. 2004 Jul 16;305(5682):390-2. doi: 10.1126/science.1099196. Epub 2004 Jun 17. Science. 2004. PMID: 15205477
Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells....
Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells....