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Page 1
Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer.
Baruteau J, Perocheau DP, Hanley J, Lorvellec M, Rocha-Ferreira E, Karda R, Ng J, Suff N, Diaz JA, Rahim AA, Hughes MP, Banushi B, Prunty H, Hristova M, Ridout DA, Virasami A, Heales S, Howe SJ, Buckley SMK, Mills PB, Gissen P, Waddington SN. Baruteau J, et al. Among authors: howe sj. Nat Commun. 2018 Aug 29;9(1):3505. doi: 10.1038/s41467-018-05972-1. Nat Commun. 2018. PMID: 30158522 Free PMC article.
Intravenous injection of AAV8 vector into adult or neonatal ASL-deficient mice demonstrates long-term correction of the hepatic urea cycle and the cerebral citrulline-NO cycle, respectively. ...
Intravenous injection of AAV8 vector into adult or neonatal ASL-deficient mice demonstrates long-term correction of the hepatic urea …
Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors.
Alonso-Ferrero ME, van Til NP, Bartolovic K, Mata MF, Wagemaker G, Moulding D, Williams DA, Kinnon C, Waddington SN, Milsom MD, Howe SJ. Alonso-Ferrero ME, et al. Among authors: howe sj. Exp Hematol. 2018 Jan;57:21-29. doi: 10.1016/j.exphem.2017.09.003. Epub 2017 Sep 11. Exp Hematol. 2018. PMID: 28911908 Free PMC article.
This property can be harnessed to express transgenes transiently to manipulate cell biology. Here, we demonstrate the utility of short-term gene expression to improve functional potency of hematopoietic stem and progenitor cells (HSPCs) during transplantation by delivering …
This property can be harnessed to express transgenes transiently to manipulate cell biology. Here, we demonstrate the utility of short-te …
Evidence for contribution of CD4+ CD25+ regulatory T cells in maintaining immune tolerance to human factor IX following perinatal adenovirus vector delivery.
Nivsarkar MS, Buckley SM, Parker AL, Perocheau D, McKay TR, Rahim AA, Howe SJ, Waddington SN. Nivsarkar MS, et al. Among authors: howe sj. J Immunol Res. 2015;2015:397879. doi: 10.1155/2015/397879. Epub 2015 Jan 31. J Immunol Res. 2015. PMID: 25759840 Free PMC article.
In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX) cDNA. The long-term tolerance of hFIX was robust in the face of immune challenge with hFIX protein and adjuvant but was eliminated by simultaneous administration of an …
In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX) cDNA. The long-term toleran …
Lentiviral labeling of mouse and human enteric nervous system stem cells for regenerative medicine studies.
Natarajan D, Cooper J, Choudhury S, Delalande JM, McCann C, Howe SJ, Thapar N, Burns AJ. Natarajan D, et al. Among authors: howe sj. Neurogastroenterol Motil. 2014 Oct;26(10):1513-8. doi: 10.1111/nmo.12420. Epub 2014 Sep 8. Neurogastroenterol Motil. 2014. PMID: 25199909 Free PMC article.
CONCLUSIONS & INFERENCES: Lentiviral vectors expressing fluorescent reporter genes enable efficient, stable, long-term labeling of ENS stem cells when transplanted into in vivo mouse gut. ...
CONCLUSIONS & INFERENCES: Lentiviral vectors expressing fluorescent reporter genes enable efficient, stable, long-term labeling o …
Systemic gene transfer of polyethylenimine (PEI)-plasmid DNA complexes to neonatal mice.
Wong SP, Argyros O, Howe SJ, Harbottle RP. Wong SP, et al. Among authors: howe sj. J Control Release. 2011 Mar 30;150(3):298-306. doi: 10.1016/j.jconrel.2010.12.010. Epub 2010 Dec 28. J Control Release. 2011. PMID: 21192993
We also investigate the specific targeting of transgene expression to the proliferating neonate liver using a liver-specific plasmid containing a Scaffold Matrix Attachment Region (S/MAR) element, which has previously been shown to confer long-term expression in adult mous …
We also investigate the specific targeting of transgene expression to the proliferating neonate liver using a liver-specific plasmid contain …
Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors.
Rahim AA, Wong AM, Howe SJ, Buckley SM, Acosta-Saltos AD, Elston KE, Ward NJ, Philpott NJ, Cooper JD, Anderson PN, Waddington SN, Thrasher AJ, Raivich G. Rahim AA, et al. Among authors: howe sj. Gene Ther. 2009 Apr;16(4):509-20. doi: 10.1038/gt.2008.186. Epub 2009 Jan 22. Gene Ther. 2009. PMID: 19158847
Non-integrating lentiviral vectors show considerable promise for gene therapy applications as they persist as long-term episomes in non-dividing cells and diminish risks of insertional mutagenesis. ...
Non-integrating lentiviral vectors show considerable promise for gene therapy applications as they persist as long-term episomes in n …
Haematopoietic repopulating activity in human cord blood CD133+ quiescent cells.
Boxall SA, Cook GP, Pearce D, Bonnet D, El-Sherbiny YM, Blundell MP, Howe SJ, Leek JP, Markham AF, de Wynter EA. Boxall SA, et al. Among authors: howe sj. Bone Marrow Transplant. 2009 Apr;43(8):627-35. doi: 10.1038/bmt.2008.368. Epub 2008 Nov 10. Bone Marrow Transplant. 2009. PMID: 18997827
This suggests that stem cell activity resides in the CD133(+)G(0) population. In long-term BM cultures, the CD133(+)G(0) cells generate significantly more progenitors than the CD34(+)G(0) population (P<0.001) throughout the culture period. ...
This suggests that stem cell activity resides in the CD133(+)G(0) population. In long-term BM cultures, the CD133(+)G(0) cells genera …
Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector.
Argyros O, Wong SP, Niceta M, Waddington SN, Howe SJ, Coutelle C, Miller AD, Harbottle RP. Argyros O, et al. Among authors: howe sj. Gene Ther. 2008 Dec;15(24):1593-605. doi: 10.1038/gt.2008.113. Epub 2008 Jul 17. Gene Ther. 2008. PMID: 18633447
Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in situ bioluminescent imaging. ...We conclude that the combination of a mammalian, tissue-specific promoter with the S/MAR element is sufficien …
Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in s …
Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.
Thornhill SI, Schambach A, Howe SJ, Ulaganathan M, Grassman E, Williams D, Schiedlmeier B, Sebire NJ, Gaspar HB, Kinnon C, Baum C, Thrasher AJ. Thornhill SI, et al. Among authors: howe sj. Mol Ther. 2008 Mar;16(3):590-8. doi: 10.1038/sj.mt.6300393. Epub 2008 Jan 8. Mol Ther. 2008. PMID: 18180772 Free PMC article.
Gene therapy for X-linked severe combined immunodeficiency (SCID-X1) has proven highly effective for long-term restoration of immunity in human subjects. However, the development of lymphoproliferative complications due to dysregulated proto-oncogene expression has underli …
Gene therapy for X-linked severe combined immunodeficiency (SCID-X1) has proven highly effective for long-term restoration of immunit …
11 results