Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms.
Vandeput F, Szabo-Fresnais N, Ahmad F, Kho C, Lee A, Krall J, Dunlop A, Hazel MW, Wohlschlegel JA, Hajjar RJ, Houslay MD, Manganiello VC, Movsesian MA.
Vandeput F, et al. Among authors: houslay md.
Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19778-83. doi: 10.1073/pnas.1305427110. Epub 2013 Nov 18.
Proc Natl Acad Sci U S A. 2013.
PMID: 24248367
Free PMC article.
Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use increases mortality in patients with heart failure. Two isoforms in cardiac myocytes, PDE3A1 and PDE3A2, have identical amino acid sequences ex …
Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use inc …