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Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7).
Henderson DJP, Houslay MD, Bangma CH, Hoffmann R. Henderson DJP, et al. Among authors: houslay md. Clin Sci (Lond). 2019 Jan 25;133(2):269-286. doi: 10.1042/CS20180519. Print 2019 Jan 31. Clin Sci (Lond). 2019. PMID: 30683712 Free article. Review.
Great clinical benefit could accrue from a biomarker able to predict long-term patient outcome accurately at the time of biopsy and initial diagnosis. ...
Great clinical benefit could accrue from a biomarker able to predict long-term patient outcome accurately at the time of biopsy and i …
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
Havekes R, Park AJ, Tolentino RE, Bruinenberg VM, Tudor JC, Lee Y, Hansen RT, Guercio LA, Linton E, Neves-Zaph SR, Meerlo P, Baillie GS, Houslay MD, Abel T. Havekes R, et al. Among authors: houslay md. J Neurosci. 2016 Aug 24;36(34):8936-46. doi: 10.1523/JNEUROSCI.0248-16.2016. J Neurosci. 2016. PMID: 27559174 Free PMC article.
However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo Here, we show that increasing protein levels of the PDE4A5 isoform in mouse hippocampal excitatory neurons impairs a long-lasting form of hippocampal synaptic plasticity and att …
However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo Here, we show that increasing protein …
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1.
Havekes R, Park AJ, Tudor JC, Luczak VG, Hansen RT, Ferri SL, Bruinenberg VM, Poplawski SG, Day JP, Aton SJ, Radwańska K, Meerlo P, Houslay MD, Baillie GS, Abel T. Havekes R, et al. Among authors: houslay md. Elife. 2016 Aug 23;5:e13424. doi: 10.7554/eLife.13424. Elife. 2016. PMID: 27549340 Free PMC article.
Suppression of cofilin function prevents spine loss, deficits in hippocampal synaptic plasticity, and impairments in long-term memory caused by sleep deprivation. The elevated cofilin activity is caused by cAMP-degrading phosphodiesterase-4A5 (PDE4A5), which hampers cAMP-P …
Suppression of cofilin function prevents spine loss, deficits in hippocampal synaptic plasticity, and impairments in long-term memory …
Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms.
Vandeput F, Szabo-Fresnais N, Ahmad F, Kho C, Lee A, Krall J, Dunlop A, Hazel MW, Wohlschlegel JA, Hajjar RJ, Houslay MD, Manganiello VC, Movsesian MA. Vandeput F, et al. Among authors: houslay md. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19778-83. doi: 10.1073/pnas.1305427110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248367 Free PMC article.
Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use increases mortality in patients with heart failure. Two isoforms in cardiac myocytes, PDE3A1 and PDE3A2, have identical amino acid sequences ex …
Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use inc …
Sleep deprivation impairs cAMP signalling in the hippocampus.
Vecsey CG, Baillie GS, Jaganath D, Havekes R, Daniels A, Wimmer M, Huang T, Brown KM, Li XY, Descalzi G, Kim SS, Chen T, Shang YZ, Zhuo M, Houslay MD, Abel T. Vecsey CG, et al. Among authors: houslay md. Nature. 2009 Oct 22;461(7267):1122-5. doi: 10.1038/nature08488. Nature. 2009. PMID: 19847264 Free PMC article.
Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression.
Kelly MP, Cheung YF, Favilla C, Siegel SJ, Kanes SJ, Houslay MD, Abel T. Kelly MP, et al. Among authors: houslay md. Learn Mem. 2008 Jan 28;15(2):75-83. doi: 10.1101/lm.723708. Print 2008 Feb. Learn Mem. 2008. PMID: 18230676 Free PMC article.
Memory formation requires cAMP signaling; thus, this cascade has been of great interest in the search for cognitive enhancers. Given that medications are administered long-term, we determined the effects of chronically increasing cAMP synthesis in the brain by expressing a …
Memory formation requires cAMP signaling; thus, this cascade has been of great interest in the search for cognitive enhancers. Given that me …
cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.
Huston E, Houslay TM, Baillie GS, Houslay MD. Huston E, et al. Among authors: houslay md. Biochem Soc Trans. 2006 Aug;34(Pt 4):504-9. doi: 10.1042/BST0340504. Biochem Soc Trans. 2006. PMID: 16856845
The irreversible, Ca(2+)-dependent insertion of the N-terminal region of PDE4A1 into membranes provides 'long-term' memory of cell activation....
The irreversible, Ca(2+)-dependent insertion of the N-terminal region of PDE4A1 into membranes provides 'long-term' memory of cell ac …
Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.
Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung YF, Campbell L, Millen JE, Smith RA, Gall I, Knowles RG, Sullivan M, Houslay MD. Wallace DA, et al. Among authors: houslay md. Mol Pharmacol. 2005 Jun;67(6):1920-34. doi: 10.1124/mol.104.009423. Epub 2005 Feb 28. Mol Pharmacol. 2005. PMID: 15738310
PDE4A11 differs from PDE4A4 in sensitivity to cleavage by caspase-3, interaction with LYN SH3 domain, redistribution upon long-term rolipram challenge, and sensitivity to certain PDE4 inhibitors. ...
PDE4A11 differs from PDE4A4 in sensitivity to cleavage by caspase-3, interaction with LYN SH3 domain, redistribution upon long-term r …
Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.
Huston E, Lumb S, Russell A, Catterall C, Ross AH, Steele MR, Bolger GB, Perry MJ, Owens RJ, Houslay MD. Huston E, et al. Among authors: houslay md. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):549-58. doi: 10.1042/bj3280549. Biochem J. 1997. PMID: 9371714 Free PMC article.
This identified an open reading frame encoding a putative 721-residue 'long-form' PDE4B splice variant, which we term HSPDE4B3. HSPDE4B3 differs from the two known PDE4B forms by virtue of its unique 79-residue N-terminal region, compared with the unique N-terminal regions …
This identified an open reading frame encoding a putative 721-residue 'long-form' PDE4B splice variant, which we term HSPDE4B3. HSPDE …
Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism.
Milligan G, Davies SA, Houslay MD, Wakelam MJ. Milligan G, et al. Among authors: houslay md. Oncogene. 1989 May;4(5):659-63. Oncogene. 1989. PMID: 2498808
Two distinct forms of Gs alpha (45 and 42 kDa) were identified. Long term over-expression of p21N-ras (T15+ cells) did not alter the levels of Gi2 alpha or of Gs alpha. ...
Two distinct forms of Gs alpha (45 and 42 kDa) were identified. Long term over-expression of p21N-ras (T15+ cells) did not alter the …