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A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure.
Benevento M, Alpár A, Gundacker A, Afjehi L, Balueva K, Hevesi Z, Hanics J, Rehman S, Pollak DD, Lubec G, Wulff P, Prevot V, Horvath TL, Harkany T. Benevento M, et al. Among authors: horvath tl. Nature. 2024 Apr;628(8009):826-834. doi: 10.1038/s41586-024-07232-3. Epub 2024 Mar 27. Nature. 2024. PMID: 38538787 Free PMC article.
Overall, we define a multimodal neurocircuit in which tanycytes link parabrachial sensory relay to the long-term enforcement of a metabolic code....
Overall, we define a multimodal neurocircuit in which tanycytes link parabrachial sensory relay to the long-term enforcement of a met …
Construction of Activity-based Anorexia Mouse Models.
Miletta MC, Horvath TL. Miletta MC, et al. Among authors: horvath tl. Bio Protoc. 2023 Aug 5;13(15):e4730. doi: 10.21769/BioProtoc.4730. eCollection 2023 Aug 5. Bio Protoc. 2023. PMID: 37575391 Free PMC article.
This protocol will be useful for future studies that aim to identify neuronal populations or brain circuits that promote the onset or long-term maintenance of this devastating eating disorder....
This protocol will be useful for future studies that aim to identify neuronal populations or brain circuits that promote the onset or long- …
Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during Adolescence.
Sestan-Pesa M, Shanabrough M, Horvath TL, Miletta MC. Sestan-Pesa M, et al. Among authors: horvath tl. Biomedicines. 2023 Jan 6;11(1):144. doi: 10.3390/biomedicines11010144. Biomedicines. 2023. PMID: 36672651 Free PMC article.
As marijuana use during adolescence has been increasing, the need to understand the effects of its long-term use becomes crucial. Previous research suggested that marijuana consumption during adolescence increases the risk of developing mental illnesses, such as schizophre …
As marijuana use during adolescence has been increasing, the need to understand the effects of its long-term use becomes crucial. Pre …
Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study.
Nedel WL, Kopczynski A, Rodolphi MS, Strogulski NR, De Bastiani M, Montes THM, Abruzzi J Jr, Galina A, Horvath TL, Portela LV. Nedel WL, et al. Among authors: horvath tl. Intensive Care Med Exp. 2021 Jul 24;9(1):39. doi: 10.1186/s40635-021-00404-9. Intensive Care Med Exp. 2021. PMID: 34304333 Free PMC article.
At a cut-off of - 0.002, deltaBCE displayed 100% sensitivity and 73% specificity for predicting 6-month mortality CONCLUSIONS: The deltaBCE signature in lymphocytes provided an earlier recognition of septic shock patients in the ICU at risk of long-term deterioration of he …
At a cut-off of - 0.002, deltaBCE displayed 100% sensitivity and 73% specificity for predicting 6-month mortality CONCLUSIONS: The deltaBCE …
Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.
Wu XS, Subramanian S, Zhang Y, Shi B, Xia J, Li T, Guo X, El-Hassar L, Szigeti-Buck K, Henao-Mejia J, Flavell RA, Horvath TL, Jonas EA, Kaczmarek LK, Wu LG. Wu XS, et al. Among authors: horvath tl. Neuron. 2021 Mar 17;109(6):938-946.e5. doi: 10.1016/j.neuron.2021.01.006. Epub 2021 Jan 27. Neuron. 2021. PMID: 33508244 Free PMC article.
AgRP neurons control compulsive exercise and survival in an activity-based anorexia model.
Miletta MC, Iyilikci O, Shanabrough M, Šestan-Peša M, Cammisa A, Zeiss CJ, Dietrich MO, Horvath TL. Miletta MC, et al. Among authors: horvath tl. Nat Metab. 2020 Nov;2(11):1204-1211. doi: 10.1038/s42255-020-00300-8. Epub 2020 Oct 26. Nat Metab. 2020. PMID: 33106687
Animals with impaired AgRP neuronal circuits are unable to properly mobilize fuels during food-restriction-associated exercise; however, when provided with elevated fat content through diet, their death is completely prevented. Elevated fat content in the diet also prevents the l …
Animals with impaired AgRP neuronal circuits are unable to properly mobilize fuels during food-restriction-associated exercise; however, whe …
Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis.
Singh AK, Aryal B, Chaube B, Rotllan N, Varela L, Horvath TL, Suárez Y, Fernández-Hernando C. Singh AK, et al. Among authors: horvath tl. Mol Metab. 2018 May;11:59-69. doi: 10.1016/j.molmet.2018.03.011. Epub 2018 Mar 29. Mol Metab. 2018. PMID: 29627378 Free PMC article.
Importantly, we observed that absence of ANGPTL4 in BAT leads to a remarkable improvement in glucose tolerance in short-term HFD feeding. CONCLUSION: Our findings demonstrate an important role of BAT derived ANGPTL4 in regulating lipoprotein metabolism, whole-body lipid an …
Importantly, we observed that absence of ANGPTL4 in BAT leads to a remarkable improvement in glucose tolerance in short-term HFD feed …
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis.
Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C. Aryal B, et al. Among authors: horvath tl. JCI Insight. 2018 Mar 22;3(6):e97918. doi: 10.1172/jci.insight.97918. JCI Insight. 2018. PMID: 29563332 Free PMC article.
As a result, we observed a remarkable improvement in glucose tolerance in short-term HFD-fed AT-specific Angptl4-KO mice. Finally, lack of ANGPTL4 in AT enhances the clearance of proatherogenic lipoproteins, attenuates inflammation, and reduces atherosclerosis. ...
As a result, we observed a remarkable improvement in glucose tolerance in short-term HFD-fed AT-specific Angptl4-KO mice. Finally, la …
Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.
Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC. Vogt MC, et al. Among authors: horvath tl. Cell. 2014 Jan 30;156(3):495-509. doi: 10.1016/j.cell.2014.01.008. Epub 2014 Jan 23. Cell. 2014. PMID: 24462248 Free PMC article.
Maternal metabolic homeostasis exerts long-term effects on the offspring's health outcomes. Here, we demonstrate that maternal high-fat diet (HFD) feeding during lactation predisposes the offspring for obesity and impaired glucose homeostasis in mice, which is associated w …
Maternal metabolic homeostasis exerts long-term effects on the offspring's health outcomes. Here, we demonstrate that maternal high-f …
29 results