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Year Number of Results
1997 1
2004 1
2010 2
2012 1
2017 1
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2020 2
2021 3
2022 2
2023 1
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16 results

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Page 1
Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial.
Perkins GD, Ji C, Connolly BA, Couper K, Lall R, Baillie JK, Bradley JM, Dark P, Dave C, De Soyza A, Dennis AV, Devrell A, Fairbairn S, Ghani H, Gorman EA, Green CA, Hart N, Hee SW, Kimbley Z, Madathil S, McGowan N, Messer B, Naisbitt J, Norman C, Parekh D, Parkin EM, Patel J, Regan SE, Ross C, Rostron AJ, Saim M, Simonds AK, Skilton E, Stallard N, Steiner M, Vancheeswaran R, Yeung J, McAuley DF; RECOVERY-RS Collaborators. Perkins GD, et al. JAMA. 2022 Feb 8;327(6):546-558. doi: 10.1001/jama.2022.0028. JAMA. 2022. PMID: 35072713 Free PMC article. Clinical Trial.
Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.
Writing Committee for the REMAP-CAP Investigators; Higgins AM, Berry LR, Lorenzi E, Murthy S, McQuilten Z, Mouncey PR, Al-Beidh F, Annane D, Arabi YM, Beane A, van Bentum-Puijk W, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Burrell A, Buzgau A, Buxton M, Charles WN, Cove M, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Horvat CM, Huang DT, Ichihara N, Lamontagne F, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Neal MD, Nichol AD, Parke RL, Parker JC, Parry-Billings K, Peters SEC, Reyes LF, Rowan KM, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Stronach LM, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Gordon AC, Webb SA, Lawler PR. Writing Committee for the REMAP-CAP Investigators, et al. JAMA. 2023 Jan 3;329(1):39-51. doi: 10.1001/jama.2022.23257. JAMA. 2023. PMID: 36525245 Free PMC article.
IMPORTANCE: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. OBJECTIVE: To determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. DESIGN, SETTING, AN …
IMPORTANCE: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. OBJECTIVE: T …
Power vectors: an application of Fourier analysis to the description and statistical analysis of refractive error.
Thibos LN, Wheeler W, Horner D. Thibos LN, et al. Among authors: horner d. Optom Vis Sci. 1997 Jun;74(6):367-75. doi: 10.1097/00006324-199706000-00019. Optom Vis Sci. 1997. PMID: 9255814 Review.
It is shown that the familiar sine-squared law leads naturally to a Fourier series representation with exactly three Fourier coefficients, representing the natural parameters of a thin lens. The constant term corresponds to the mean spherical equivalent (MSE) power, wherea …
It is shown that the familiar sine-squared law leads naturally to a Fourier series representation with exactly three Fourier coefficients, r …
Phylogenetic analyses: a brief introduction to methods and their application.
Horner DS, Pesole G. Horner DS, et al. Expert Rev Mol Diagn. 2004 May;4(3):339-50. doi: 10.1586/14737159.4.3.339. Expert Rev Mol Diagn. 2004. PMID: 15137901 Review.
The aims of this review are to introduce some of the methods used to construct phylogenetic trees, to illustrate some of the pitfalls that can introduce artifactual results and to speculate on the long-term importance of this area of computational biology in clinical medic …
The aims of this review are to introduce some of the methods used to construct phylogenetic trees, to illustrate some of the pitfalls that c …
Need for recovery amongst emergency physicians in the UK and Ireland: a cross-sectional survey.
Cottey L, Roberts T, Graham B, Horner D, Stevens KN, Enki D, Lyttle MD, Latour J; Trainee Emergency Research Network (TERN) and Paediatric Emergency Research in the UK and Ireland (PERUKI). Cottey L, et al. Among authors: horner d. BMJ Open. 2020 Nov 2;10(11):e041485. doi: 10.1136/bmjopen-2020-041485. BMJ Open. 2020. PMID: 33139301 Free PMC article.
Groups including male physicians, consultants, general practitioners (GPs) within the ED, those working in paediatric EDs and those with no long-term health condition or disability had a lower NFR Score. After adjusting for these characteristics, the NFR Score increased by …
Groups including male physicians, consultants, general practitioners (GPs) within the ED, those working in paediatric EDs and those with no …
Sugar or salt ("SOS"): A protocol for a UK multicentre randomised trial of mannitol and hypertonic saline in severe traumatic brain injury and intracranial hypertension.
Rowland MJ, Veenith T, Scomparin C, Wilson MH, Hutchinson PJ, Kolias AG, Lall R, Regan S, Mason J, Andrews P, Horner D, Naisbitt J, Devrell A, Malins A, Dark P, McAuley DF, Perkins GD. Rowland MJ, et al. Among authors: horner d. J Intensive Care Soc. 2022 May;23(2):222-232. doi: 10.1177/1751143720901690. Epub 2020 Feb 25. J Intensive Care Soc. 2022. PMID: 35615234 Free PMC article.
Results will inform current clinical practice in the routine use of hyperosmolar therapy as well as assess the impact of potential side effects. Pre-planned longer term clinical and cost effectiveness analyses will further inform the use of these treatments....
Results will inform current clinical practice in the routine use of hyperosmolar therapy as well as assess the impact of potential side effe …
An innovative method to classify SERMs based on the dynamics of estrogen receptor transcriptional activity in living animals.
Rando G, Horner D, Biserni A, Ramachandran B, Caruso D, Ciana P, Komm B, Maggi A. Rando G, et al. Among authors: horner d. Mol Endocrinol. 2010 Apr;24(4):735-44. doi: 10.1210/me.2009-0514. Epub 2010 Mar 2. Mol Endocrinol. 2010. PMID: 20197311 Free PMC article.
Using a mouse model engineered to measure estrogen receptor (ER) transcriptional activity in living organisms, we investigated the effect of long-term (21 d) hormone replacement on ER signaling by whole-body in vivo imaging. ...
Using a mouse model engineered to measure estrogen receptor (ER) transcriptional activity in living organisms, we investigated the effect of …
CONSTANS Imparts DNA Sequence Specificity to the Histone Fold NF-YB/NF-YC Dimer.
Gnesutta N, Kumimoto RW, Swain S, Chiara M, Siriwardana C, Horner DS, Holt BF 3rd, Mantovani R. Gnesutta N, et al. Among authors: horner ds. Plant Cell. 2017 Jun;29(6):1516-1532. doi: 10.1105/tpc.16.00864. Epub 2017 May 19. Plant Cell. 2017. PMID: 28526714 Free PMC article.
We show that CONSTANS (CO/B-BOX PROTEIN1 BBX1), a master flowering regulator, forms a trimer with Arabidopsis thaliana NF-YB2/NF-YC3 to efficiently bind the CORE element of the FLOWERING LOCUS T promoter. We term this complex NF-CO. Using saturation mutagenesis, electropho …
We show that CONSTANS (CO/B-BOX PROTEIN1 BBX1), a master flowering regulator, forms a trimer with Arabidopsis thaliana NF-YB2/NF-YC3 to effi …
Whole transcriptome profiling of Late-Onset Alzheimer's Disease patients provides insights into the molecular changes involved in the disease.
Annese A, Manzari C, Lionetti C, Picardi E, Horner DS, Chiara M, Caratozzolo MF, Tullo A, Fosso B, Pesole G, D'Erchia AM. Annese A, et al. Among authors: horner ds. Sci Rep. 2018 Mar 9;8(1):4282. doi: 10.1038/s41598-018-22701-2. Sci Rep. 2018. PMID: 29523845 Free PMC article.
Notably, a luciferase assay indicates that miR-184 is able to target the 3'UTR NR4A2 - which is known to be involved in cognitive functions and long-term memory and whose expression levels are inversely correlated with those of miR-184 in the hippocampus. ...
Notably, a luciferase assay indicates that miR-184 is able to target the 3'UTR NR4A2 - which is known to be involved in cognitive functions …
The Headache in Emergency Departments study: Opioid prescribing in patients presenting with headache. A multicenter, cross-sectional, observational study.
Pellatt RAF, Kamona S, Chu K, Sweeny A, Kuan WS, Kinnear FB, Karamercan MA, Klim S, Wijeratne T, Graham CA, Body R, Roberts T, Horner D, Laribi S, Keijzers G, Kelly AM. Pellatt RAF, et al. Among authors: horner d. Headache. 2021 Oct;61(9):1387-1402. doi: 10.1111/head.14217. Epub 2021 Oct 10. Headache. 2021. PMID: 34632592
Independent predictors of ED opioid administration included the following: severe headache (OR 4.2, 95% CI 3.1-5.5), pre-ED opioid use (OR 1.42, 95% CI 1.11-1.82), and long-term opioid use (OR 1.80, 95% CI 1.26-2.58). ED opioid administration independently predicted opioid …
Independent predictors of ED opioid administration included the following: severe headache (OR 4.2, 95% CI 3.1-5.5), pre-ED opioid use (OR 1 …
16 results