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Wildfire-related PM2.5 and DNA methylation: An Australian twin and family study.
Xu R, Li S, Wu Y, Yue X, Wong EM, Southey MC, Hopper JL, Abramson MJ, Li S, Guo Y. Xu R, et al. Among authors: hopper jl. Environ Int. 2023 Jan;171:107704. doi: 10.1016/j.envint.2022.107704. Epub 2022 Dec 17. Environ Int. 2023. PMID: 36542997 Free article.
BACKGROUND: Wildfire-related fine particulate matter (PM(2.5)) has many adverse health impacts, but its impacts on human epigenome are unknown. We aimed to evaluate the associations between long-term exposure to wildfire-related PM(2.5) and blood DNA methylation, and wheth …
BACKGROUND: Wildfire-related fine particulate matter (PM(2.5)) has many adverse health impacts, but its impacts on human epigenome are unkno …
Epigenome-wide association study of short-term temperature fluctuations based on within-sibship analyses in Australian females.
Wu Y, Xu R, Li S, Ming Wong E, Southey MC, Hopper JL, Abramson MJ, Li S, Guo Y. Wu Y, et al. Among authors: hopper jl. Environ Int. 2023 Jan;171:107655. doi: 10.1016/j.envint.2022.107655. Epub 2022 Nov 24. Environ Int. 2023. PMID: 36476687 Free article.
BACKGROUND: Temperature fluctuations can affect human health independent of the effect of mean temperature. However, no study has evaluated whether short-term temperature fluctuations could affect DNA methylation. METHODS: Peripheral blood DNA methylation for 479 female si …
BACKGROUND: Temperature fluctuations can affect human health independent of the effect of mean temperature. However, no study has evaluated …
A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women.
Wang X, Chen H, Middha Kapoor P, Su YR, Bolla MK, Dennis J, Dunning AM, Lush M, Wang Q, Michailidou K, Pharoah PDP, Hopper JL, Southey MC, Koutros S, Beane Freeman LE, Stone J, Rennert G, Shibli R, Murphy RA, Aronson K, Guénel P, Truong T, Teras LR, Hodge JM, Canzian F, Kaaks R, Brenner H, Arndt V, Hoppe R, Lo WY, Behrens S, Mannermaa A, Kosma VM, Jung A, Becher H, Giles GG, Haiman CA, Maskarinec G, Scott C, Winham S, Simard J, Goldberg MS, Zheng W, Long J, Troester MA, Love MI, Peng C, Tamimi R, Eliassen H, García-Closas M, Figueroa J, Ahearn T, Yang R, Evans DG, Howell A, Hall P, Czene K, Wolk A, Sandler DP, Taylor JA, Swerdlow AJ, Orr N, Lacey JV, Wang S, Olsson H, Easton DF, Milne RL, Hsu L, Kraft P, Chang-Claude J, Lindström S. Wang X, et al. Among authors: hopper jl. Cancer Res Commun. 2022 Apr;2(4):211-219. doi: 10.1158/2767-9764.CRC-21-0119. Epub 2022 Apr 8. Cancer Res Commun. 2022. PMID: 36303815 Free PMC article.
The strongest interaction observed was between the predicted expression of the C13orf45 gene and age at first full-term pregnancy (P(GXE)=4.4410(-6)). CONCLUSION: In this transcriptome-informed genome-wide gene-environment interaction study of breast cancer, we found no st …
The strongest interaction observed was between the predicted expression of the C13orf45 gene and age at first full-term pregnancy (P( …
Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?
Yu C, Hodge AM, Wong EM, Joo JE, Makalic E, Schmidt DF, Buchanan DD, Severi G, Hopper JL, English DR, Giles GG, Milne RL, Southey MC, Dugué PA. Yu C, et al. Among authors: hopper jl. Epigenetics. 2022 Dec;17(12):1838-1847. doi: 10.1080/15592294.2022.2088038. Epub 2022 Jun 20. Epigenetics. 2022. PMID: 35726372 Free PMC article.
There was weak evidence that the association of smoking with GrimAge was attenuated in participants genetically predisposed to smoking (interaction term: -0.022, standard error [SE] = 0.012, P = 0.058) and that the association of alcohol consumption with PhenoAge was atten …
There was weak evidence that the association of smoking with GrimAge was attenuated in participants genetically predisposed to smoking (inte …
Association between very to moderate preterm births, lung function deficits, and COPD at age 53 years: analysis of a prospective cohort study.
Bui DS, Perret JL, Walters EH, Lodge CJ, Bowatte G, Hamilton GS, Thompson BR, Frith P, Erbas B, Thomas PS, Johns DP, Wood-Baker R, Hopper JL, Davis PG, Abramson MJ, Lowe AJ, Dharmage SC. Bui DS, et al. Among authors: hopper jl. Lancet Respir Med. 2022 May;10(5):478-484. doi: 10.1016/S2213-2600(21)00508-7. Epub 2022 Feb 18. Lancet Respir Med. 2022. PMID: 35189074
RESULTS: Of 3565 individuals with available data on gestational age from the TAHS cohort, 1445 (41%) participants were included in this study, 740 (51%) of whom were female. Compared with term birth, very to moderate preterm birth was significantly associated …
RESULTS: Of 3565 individuals with available data on gestational age from the TAHS cohort, 1445 (41%) participants were included in this stud …
Oral Contraceptive Use in BRCA1 and BRCA2 Mutation Carriers: Absolute Cancer Risks and Benefits.
Schrijver LH, Mooij TM, Pijpe A, Sonke GS, Mourits MJE, Andrieu N, Antoniou AC, Easton DF, Engel C, Goldgar D, John EM, Kast K, Milne RL, Olsson H, Phillips KA, Terry MB, Hopper JL, van Leeuwen FE, Rookus MA. Schrijver LH, et al. Among authors: hopper jl. J Natl Cancer Inst. 2022 Apr 11;114(4):540-552. doi: 10.1093/jnci/djac004. J Natl Cancer Inst. 2022. PMID: 35048954 Free PMC article.
RESULTS: COCP use initially increased breast cancer risk and decreased ovarian and endometrial cancer risk long term. For 10 000 BRCA1 mutation carriers, 10 years of COCP use from age 20 to 30 years resulted in 66 additional COCP-associated cancer cases by the age of 35 ye …
RESULTS: COCP use initially increased breast cancer risk and decreased ovarian and endometrial cancer risk long term. For 10 000 BRCA …
Prospective Evaluation over 15 Years of Six Breast Cancer Risk Models.
Li SX, Milne RL, Nguyen-Dumont T, English DR, Giles GG, Southey MC, Antoniou AC, Lee A, Winship I, Hopper JL, Terry MB, MacInnis RJ. Li SX, et al. Among authors: hopper jl. Cancers (Basel). 2021 Oct 16;13(20):5194. doi: 10.3390/cancers13205194. Cancers (Basel). 2021. PMID: 34680343 Free PMC article.
Prospective validation of risk models is needed to assess their clinical utility, particularly over the longer term. We evaluated the performance of six commonly used breast cancer risk models (IBIS, BOADICEA, BRCAPRO, BRCAPRO-BCRAT, BCRAT, and iCARE-lit). 15-year risk sco …
Prospective validation of risk models is needed to assess their clinical utility, particularly over the longer term. We evaluated the …
Ambient temperature and genome-wide DNA methylation: A twin and family study in Australia.
Xu R, Li S, Li S, Wong EM, Southey MC, Hopper JL, Abramson MJ, Guo Y. Xu R, et al. Among authors: hopper jl. Environ Pollut. 2021 Sep 15;285:117700. doi: 10.1016/j.envpol.2021.117700. Epub 2021 Jul 1. Environ Pollut. 2021. PMID: 34380236
., diabetes, arthritis, breast cancer, depression, asthma, body height) in previous studies. The signals of short-term windows (lag0d and lag0-21d) showed enrichment in biological processes related to cell adhesion. In conclusion, short-, medium-, and long-term expo …
., diabetes, arthritis, breast cancer, depression, asthma, body height) in previous studies. The signals of short-term windows (lag0d …
Enhancing Value and Uptake for Whole-Population Cohorts of Children and Parents: Methods to Integrate Registries into the Generation Victoria Cohort.
Sung V, Williams K, Perlow E, Hu YJ, Ahern S, Said JM, Karanatsios B, Hopper JL, McNeil JJ, Donnan L, Goldfeld S, Wake M. Sung V, et al. Among authors: hopper jl. Children (Basel). 2021 Apr 7;8(4):285. doi: 10.3390/children8040285. Children (Basel). 2021. PMID: 33917154 Free PMC article.
By design, it will include linked datasets, biosamples (including from pregnancy), phenotypes and participant-reported measures, all of which will span pre-morbid to long-term outcomes. We provide a vignette of a planned new registry for high-risk pregnancies to illustrate …
By design, it will include linked datasets, biosamples (including from pregnancy), phenotypes and participant-reported measures, all of whic …
Prediagnosis alcohol intake and metachronous cancer risk in cancer survivors: A prospective cohort study.
Jayasekara H, Hodge AM, Haydon A, Room R, Hopper JL, English DR, Smith-Warner SA, Giles GG, Milne RL, MacInnis RJ. Jayasekara H, et al. Among authors: hopper jl. Int J Cancer. 2021 Apr 19. doi: 10.1002/ijc.33603. Online ahead of print. Int J Cancer. 2021. PMID: 33872391 Free article.
Alcohol intake trajectories over the life course confirmed associations with metachronous cancer risk. Prediagnosis long-term alcohol intake, and particularly heavy drinking, may increase the risk of metachronous cancer, particularly of the colorectum, UADT and kidney....
Alcohol intake trajectories over the life course confirmed associations with metachronous cancer risk. Prediagnosis long-term alcohol …
47 results