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Twelve-year outcomes of watchful waiting versus surgery of mildly symptomatic or asymptomatic inguinal hernia in men aged 50 years and older: a randomised controlled trial.
Van den Dop LM, Van Egmond S, Heijne J, van Rosmalen J, de Goede B, Wijsmuller AR, Kleinrensink GJ, Tanis PJ, Jeekel J, Lange JF; INCA Trialists' Collaboration. Van den Dop LM, et al. EClinicalMedicine. 2023 Sep 15;64:102207. doi: 10.1016/j.eclinm.2023.102207. eCollection 2023 Oct. EClinicalMedicine. 2023. PMID: 37936657 Free PMC article.
The value of watchful waiting (WW) in patients with asymptomatic or mildly symptomatic inguinal hernia has been established in a few randomised controlled trials (RCTs). The aim of this study was to assess long-term outcomes of a RCT comparing WW and elective surgery. METH …
The value of watchful waiting (WW) in patients with asymptomatic or mildly symptomatic inguinal hernia has been established in a few randomi …
Laparoscopic peritoneal lavage versus sigmoidectomy for perforated diverticulitis with purulent peritonitis: three-year follow-up of the randomised LOLA trial.
Hoek VT, Edomskis PP, Stark PW, Lambrichts DPV, Draaisma WA, Consten ECJ, Lange JF, Bemelman WA; LADIES trial collaborators. Hoek VT, et al. Surg Endosc. 2022 Oct;36(10):7764-7774. doi: 10.1007/s00464-022-09326-3. Epub 2022 May 23. Surg Endosc. 2022. PMID: 35606544 Free PMC article. Clinical Trial.
Eventually, 17 of 38 (45%) patients allocated to lavage underwent sigmoidectomy. CONCLUSION: Long-term outcomes showed that laparoscopic lavage was associated with less patients who underwent reoperations and lower stoma rates in patients alive after 36 months compared to …
Eventually, 17 of 38 (45%) patients allocated to lavage underwent sigmoidectomy. CONCLUSION: Long-term outcomes showed that laparosco …
Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial.
Lambrichts DPV, Vennix S, Musters GD, Mulder IM, Swank HA, Hoofwijk AGM, Belgers EHJ, Stockmann HBAC, Eijsbouts QAJ, Gerhards MF, van Wagensveld BA, van Geloven AAW, Crolla RMPH, Nienhuijs SW, Govaert MJPM, di Saverio S, D'Hoore AJL, Consten ECJ, van Grevenstein WMU, Pierik REGJM, Kruyt PM, van der Hoeven JAB, Steup WH, Catena F, Konsten JLM, Vermeulen J, van Dieren S, Bemelman WA, Lange JF; LADIES trial collaborators. Lambrichts DPV, et al. Lancet Gastroenterol Hepatol. 2019 Aug;4(8):599-610. doi: 10.1016/S2468-1253(19)30174-8. Epub 2019 Jun 6. Lancet Gastroenterol Hepatol. 2019. PMID: 31178342 Clinical Trial.
In 17 (27%) of 64 patients assigned to primary anastomosis, no stoma was constructed. 12-month stoma-free survival was significantly better for patients undergoing primary anastomosis compared with Hartmann's procedure (94.6% [95% CI 88.7-100] vs 71.7% [95% CI 60.1-83.3], hazard …
In 17 (27%) of 64 patients assigned to primary anastomosis, no stoma was constructed. 12-month stoma-free survival was significantly better …
Prevention of incisional hernia with prophylactic onlay and sublay mesh reinforcement versus primary suture only in midline laparotomies (PRIMA): 2-year follow-up of a multicentre, double-blind, randomised controlled trial.
Jairam AP, Timmermans L, Eker HH, Pierik REGJM, van Klaveren D, Steyerberg EW, Timman R, van der Ham AC, Dawson I, Charbon JA, Schuhmacher C, Mihaljevic A, Izbicki JR, Fikatas P, Knebel P, Fortelny RH, Kleinrensink GJ, Lange JF, Jeekel HJ; PRIMA Trialist Group. Jairam AP, et al. Lancet. 2017 Aug 5;390(10094):567-576. doi: 10.1016/S0140-6736(17)31332-6. Epub 2017 Jun 20. Lancet. 2017. PMID: 28641875 Clinical Trial.
BACKGROUND: Incisional hernia is a frequent long-term complication after abdominal surgery, with a prevalence greater than 30% in high-risk groups. ...
BACKGROUND: Incisional hernia is a frequent long-term complication after abdominal surgery, with a prevalence greater than 30% in hig …
Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial.
Vennix S, Musters GD, Mulder IM, Swank HA, Consten EC, Belgers EH, van Geloven AA, Gerhards MF, Govaert MJ, van Grevenstein WM, Hoofwijk AG, Kruyt PM, Nienhuijs SW, Boermeester MA, Vermeulen J, van Dieren S, Lange JF, Bemelman WA; Ladies trial colloborators. Vennix S, et al. Lancet. 2015 Sep 26;386(10000):1269-1277. doi: 10.1016/S0140-6736(15)61168-0. Epub 2015 Jul 22. Lancet. 2015. PMID: 26209030 Clinical Trial.
We aimed to assess the superiority of laparoscopic lavage compared with sigmoidectomy in patients with purulent perforated diverticulitis, with respect to overall long-term morbidity and mortality. METHODS: We did a multicentre, parallel-group, randomised, open-label trial …
We aimed to assess the superiority of laparoscopic lavage compared with sigmoidectomy in patients with purulent perforated diverticulitis, w …
The influence of mechanical bowel preparation on long-term survival in patients surgically treated for colorectal cancer.
van't Sant HP, Kamman A, Hop WC, van der Heijden M, Lange JF, Contant CM. van't Sant HP, et al. Among authors: hop wc. Am J Surg. 2015 Jul;210(1):106-10. doi: 10.1016/j.amjsurg.2014.10.022. Epub 2015 Jan 21. Am J Surg. 2015. PMID: 25754845 Clinical Trial.
BACKGROUND: In this study, we evaluated long-term survival in patients treated with and without mechanical bowel preparation (MBP) before colorectal surgery for cancer. ...CONCLUSIONS: Our results indicate that MBP does not seem to influence long-term survival in pa …
BACKGROUND: In this study, we evaluated long-term survival in patients treated with and without mechanical bowel preparation (MBP) be …
A double blind randomized controlled trial comparing primary suture closure with mesh augmented closure to reduce incisional hernia incidence.
Nieuwenhuizen J, Eker HH, Timmermans L, Hop WC, Kleinrensink GJ, Jeekel J, Lange JF; PRIMA Trialist Group. Nieuwenhuizen J, et al. Among authors: hop wc. BMC Surg. 2013 Oct 28;13:48. doi: 10.1186/1471-2482-13-48. BMC Surg. 2013. PMID: 24499111 Free PMC article. Clinical Trial.
BACKGROUND: Incisional hernia is the most frequently seen long term complication after laparotomy causing much morbidity and even mortality. ...
BACKGROUND: Incisional hernia is the most frequently seen long term complication after laparotomy causing much morbidity and even mor …
Small airway deposition of dornase alfa during exacerbations in cystic fibrosis; a randomized controlled clinical trial.
Bakker EM, Volpi S, Salonini E, Müllinger B, Kroneberg P, Bakker M, Hop WC, Assael BM, Tiddens HA. Bakker EM, et al. Among authors: hop wc. Pediatr Pulmonol. 2014 Feb;49(2):154-61. doi: 10.1002/ppul.22800. Epub 2013 Jul 3. Pediatr Pulmonol. 2014. PMID: 23913868 Clinical Trial.
Additionally, many CF patients lose lung function in the long term as a result of respiratory tract exacerbations (RTEs). No trials have been performed to optimize mucolytic therapy during a RTE. ...
Additionally, many CF patients lose lung function in the long term as a result of respiratory tract exacerbations (RTEs). No trials h …
99 results