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Impact of haemoconcentration during acute heart failure therapy on mortality and its relationship with worsening renal function.
Breidthardt T, Weidmann ZM, Twerenbold R, Gantenbein C, Stallone F, Rentsch K, Rubini Gimenez M, Kozhuharov N, Sabti Z, Breitenbücher D, Wildi K, Puelacher C, Honegger U, Wagener M, Schumacher C, Hillinger P, Osswald S, Mueller C. Breidthardt T, et al. Among authors: honegger u. Eur J Heart Fail. 2017 Feb;19(2):226-236. doi: 10.1002/ejhf.667. Epub 2016 Oct 19. Eur J Heart Fail. 2017. PMID: 27758007 Free article.
We aimed to characterize further the impact of in-hospital haemoconcentration and worsening renal function (WRF) on short- and long-term mortality. METHODS AND RESULTS: Haematocrit, haemoglobin, total protein, serum creatinine, and albumin levels were measured serially in …
We aimed to characterize further the impact of in-hospital haemoconcentration and worsening renal function (WRF) on short- and long-term …
Antidepressant-induced switch of beta 1-adrenoceptor trafficking as a mechanism for drug action.
Bürgi S, Baltensperger K, Honegger UE. Bürgi S, et al. Among authors: honegger ue. J Biol Chem. 2003 Jan 10;278(2):1044-52. doi: 10.1074/jbc.M209972200. Epub 2002 Oct 21. J Biol Chem. 2003. PMID: 12393876 Free article.
Reduction in surface beta(1)-adrenoceptor (beta1AR) density is thought to play a critical role in mediating the therapeutic long term effects of antidepressants. Since antidepressants are neither agonists nor antagonists for G protein-coupled receptors, receptor density mu …
Reduction in surface beta(1)-adrenoceptor (beta1AR) density is thought to play a critical role in mediating the therapeutic long term …
Evidence for lysosomotropic action of desipramine in cultured human fibroblasts.
Honegger UE, Roscher AA, Wiesmann UN. Honegger UE, et al. J Pharmacol Exp Ther. 1983 May;225(2):436-41. J Pharmacol Exp Ther. 1983. PMID: 6221090
Similar to the lysosomotropic agent, chloroquine, desipramine interferes with the lysosomal degradation of endogenous sulfated mucopolysaccharides in a dose-dependent manner. In contrast to short time exposure, long-term treatment with desipramine produces intracellular gr …
Similar to the lysosomotropic agent, chloroquine, desipramine interferes with the lysosomal degradation of endogenous sulfated mucopolysacch …