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Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: a post-treatment analysis of a randomised placebo-controlled trial.
Jensen SBK, Blond MB, Sandsdal RM, Olsen LM, Juhl CR, Lundgren JR, Janus C, Stallknecht BM, Holst JJ, Madsbad S, Torekov SS. Jensen SBK, et al. Among authors: holst jj. EClinicalMedicine. 2024 Feb 19;69:102475. doi: 10.1016/j.eclinm.2024.102475. eCollection 2024 Mar. EClinicalMedicine. 2024. PMID: 38544798 Free PMC article.
BACKGROUND: New obesity medications result in large weight losses. However, long-term adherence in a real-world setting is challenging, and termination of obesity medication results in weight regain towards pre-treatment body weight. ...
BACKGROUND: New obesity medications result in large weight losses. However, long-term adherence in a real-world setting is challengin …
Signs of Glucagon Resistance After a 2-Week Hypercaloric Diet Intervention.
Suppli MP, Høgedal A, Bagger JI, Chabanova E, van Hall G, Forman JL, Christensen MB, Albrechtsen NJW, Holst JJ, Knop FK. Suppli MP, et al. Among authors: holst jj. J Clin Endocrinol Metab. 2024 Mar 15;109(4):955-967. doi: 10.1210/clinem/dgad666. J Clin Endocrinol Metab. 2024. PMID: 37967235
The changes were normalized at follow-up. CONCLUSION: Our results indicate that short-term unhealthy behavior, which increases hepatic fat content, causes a reversible resistance to the effect of glucagon on amino acid concentrations in healthy individuals, which may expla …
The changes were normalized at follow-up. CONCLUSION: Our results indicate that short-term unhealthy behavior, which increases hepati …
Combination of exercise and GLP-1 receptor agonist treatment reduces severity of metabolic syndrome, abdominal obesity, and inflammation: a randomized controlled trial.
Sandsdal RM, Juhl CR, Jensen SBK, Lundgren JR, Janus C, Blond MB, Rosenkilde M, Bogh AF, Gliemann L, Jensen JB, Antoniades C, Stallknecht BM, Holst JJ, Madsbad S, Torekov SS. Sandsdal RM, et al. Among authors: holst jj. Cardiovasc Diabetol. 2023 Feb 25;22(1):41. doi: 10.1186/s12933-023-01765-z. Cardiovasc Diabetol. 2023. PMID: 36841762 Free PMC article. Clinical Trial.
The metabolic syndrome is associated with abdominal obesity and inflammation and is predictive of long-term risk of developing type 2 diabetes and cardiovascular disease in otherwise healthy individuals living with obesity. ...
The metabolic syndrome is associated with abdominal obesity and inflammation and is predictive of long-term risk of developing type 2 …
Effects of topical corticosteroid versus tacrolimus on insulin sensitivity and bone homeostasis in adults with atopic dermatitis-A randomized controlled study.
Gether L, Storgaard H, Kezic S, Jakasa I, Hartmann B, Skov-Jeppesen K, Holst JJ, Pedersen AJ, Forman J, van Hall G, Sørensen OE, Skov L, Røpke MA, Knop FK, Thyssen JP. Gether L, et al. Among authors: holst jj. Allergy. 2023 Jul;78(7):1964-1979. doi: 10.1111/all.15690. Epub 2023 Mar 21. Allergy. 2023. PMID: 36824052 Clinical Trial.
CONCLUSIONS: Whole-body treatment with TCS leads to systemic exposure but appears not to compromise glucose metabolism during short-term use, which may be a result of reduced systemic inflammatory activity. ...
CONCLUSIONS: Whole-body treatment with TCS leads to systemic exposure but appears not to compromise glucose metabolism during short-term …
Are SADI-S and BPD/DS bariatric procedures identical twins or distant relatives? - A case report.
Guimarães M, Pereira AM, Pereira SS, Almeida R, Lobato CB, Hartmann B, Holst JJ, Nora M, Monteiro MP. Guimarães M, et al. Among authors: holst jj. Obes Res Clin Pract. 2023 Mar-Apr;17(2):166-170. doi: 10.1016/j.orcp.2023.02.004. Epub 2023 Feb 13. Obes Res Clin Pract. 2023. PMID: 36792463 Free article.
Given the common anatomical features and similar short-term weight loss outcomes, Biliopancreatic Diversion with Duodenal Switch (BPD/DS) and Single-Anastomosis Duodenoileal bypass with Sleeve gastrectomy (SADI-S) are considered identical bariatric procedures, apart from t …
Given the common anatomical features and similar short-term weight loss outcomes, Biliopancreatic Diversion with Duodenal Switch (BPD …
Butyrate and hexanoate-enriched triglycerides increase postprandrial systemic butyrate and hexanoate in men with overweight/obesity: A double-blind placebo-controlled randomized crossover trial.
van Deuren T, Smolders L, Hartog A, Bouwman FG, Holst JJ, Venema K, Blaak EE, Canfora EE. van Deuren T, et al. Among authors: holst jj. Front Nutr. 2023 Jan 4;9:1066950. doi: 10.3389/fnut.2022.1066950. eCollection 2022. Front Nutr. 2023. PMID: 36687671 Free PMC article.
Future randomized clinical trials should investigate whether long-term Akovita SCT supplementation can aid in the treatment or prevention of metabolic disorders. ...
Future randomized clinical trials should investigate whether long-term Akovita SCT supplementation can aid in the treatment or preven …
New therapies for obesity.
Papamargaritis D, le Roux CW, Holst JJ, Davies MJ. Papamargaritis D, et al. Among authors: holst jj. Cardiovasc Res. 2024 Feb 17;119(18):2825-2842. doi: 10.1093/cvr/cvac176. Cardiovasc Res. 2024. PMID: 36448672 Free PMC article.
Weight loss (WL) through lifestyle changes results in modest WL long-term possibly due to compensatory biological adaptations (increased appetite and reduced energy expenditure) promoting weight gain. ...
Weight loss (WL) through lifestyle changes results in modest WL long-term possibly due to compensatory biological adaptations (increa …
Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells.
Elmelund E, Galsgaard KD, Johansen CD, Trammell SAJ, Bomholt AB, Winther-Sørensen M, Hunt JE, Sørensen CM, Kruse T, Lau JF, Grevengoed TJ, Holst JJ, Wewer Albrechtsen NJ. Elmelund E, et al. Among authors: holst jj. iScience. 2022 Oct 6;25(11):105296. doi: 10.1016/j.isci.2022.105296. eCollection 2022 Nov 18. iScience. 2022. PMID: 36325048 Free PMC article.
Our results support the importance of glucagon receptor signaling for amino acid homeostasis and pancreatic islet integrity in mice and provide knowledge regarding the long-term consequences of chronic glucagon receptor agonism and antagonism....
Our results support the importance of glucagon receptor signaling for amino acid homeostasis and pancreatic islet integrity in mice and prov …
Acute effects on glucose tolerance by neprilysin inhibition in patients with type 2 diabetes.
Wewer Albrechtsen NJ, Møller A, Martinussen C, Gluud LL, Rashu EB, Richter MM, Plomgaard P, Goetze JP, Kjeldsen S, Hansen LH, Gustafsson F, Deacon CF, Holst JJ, Madsbad S, Bojsen-Møller KN. Wewer Albrechtsen NJ, et al. Among authors: holst jj. Diabetes Obes Metab. 2022 Oct;24(10):2017-2026. doi: 10.1111/dom.14789. Epub 2022 Jul 21. Diabetes Obes Metab. 2022. PMID: 35676803 Free PMC article. Clinical Trial.
Glucagon, GLP-1 and C-peptide concentrations increased after sacubitril/valsartan, but insulin and glucose-dependent insulinotropic polypeptide did not change. CONCLUSIONS: The glucose-lowering effects of long-term sacubitril/valsartan treatment reported in patients with h …
Glucagon, GLP-1 and C-peptide concentrations increased after sacubitril/valsartan, but insulin and glucose-dependent insulinotropic polypept …
Discovery of the GI Effects of GLP-1: An Historical Perspective.
Holst JJ. Holst JJ. Dig Dis Sci. 2022 Jul;67(7):2716-2720. doi: 10.1007/s10620-022-07519-3. Epub 2022 May 30. Dig Dis Sci. 2022. PMID: 35635627 Review.
Based on these studies, it was concluded that GLP-1 is an important regulator of the so-called ileal brake, a term given for the observation that ileal perfusion of lipids delayed gastric emptying, reduced food intake, and induced satiety Welch et al. (1985), in addition t …
Based on these studies, it was concluded that GLP-1 is an important regulator of the so-called ileal brake, a term given for the obse …
113 results