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Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Rasouli N, Younes N, Ghosh A, Albu J, Cohen RM, DeFronzo RA, Diaz E, Sayyed Kassem L, Luchsinger JA, McGill JB, Sivitz WI, Tamborlane WV, Utzschneider KM, Kahn SE; GRADE Research Group. Rasouli N, et al. Diabetes Care. 2024 Apr 1;47(4):580-588. doi: 10.2337/dc23-1070. Diabetes Care. 2024. PMID: 38211595 Clinical Trial.
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity and beta-cell function. ...After adjustment for HOMA2-%S to obtain an estimate of …
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and si …
Impact of Insulin Sensitivity and β-Cell Function Over Time on Glycemic Outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): Differential Treatment Effects of Dual Therapy.
Utzschneider KM, Younes N, Butera NM, Balasubramanyam A, Bergenstal RM, Barzilay J, DeSouza C, DeFronzo RA, Elasy T, Krakoff J, Kahn SE, Rasouli N, Valencia WM, Sivitz WI; GRADE Research Group. Utzschneider KM, et al. Diabetes Care. 2024 Apr 1;47(4):571-579. doi: 10.2337/dc23-1059. Diabetes Care. 2024. PMID: 38190619 Clinical Trial.
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in the sitagliptin group on initial (short-term) HbA1c response in comparison with the glimepiride and liraglutide groups....
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in …
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.
C-MORE/PHOSP-COVID Collaborative Group. C-MORE/PHOSP-COVID Collaborative Group. Lancet Respir Med. 2023 Nov;11(11):1003-1019. doi: 10.1016/S2213-2600(23)00262-X. Epub 2023 Sep 22. Lancet Respir Med. 2023. PMID: 37748493 Free PMC article.
INTERPRETATION: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeu …
INTERPRETATION: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings e …
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.
Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE, Chalder T, Chalmers JD, Chaudhuri N, Docherty AB, Donaldson G, Edwardson CL, Elneima O, Greening NJ, Hanley NA, Harris VC, Harrison EM, Ho LP, Houchen-Wolloff L, Howard LS, Jolley CJ, Jones MG, Leavy OC, Lewis KE, Lone NI, Marks M, McAuley HJC, McNarry MA, Patel BV, Piper-Hanley K, Poinasamy K, Raman B, Richardson M, Rivera-Ortega P, Rowland-Jones SL, Rowlands AV, Saunders RM, Scott JT, Sereno M, Shah AM, Shikotra A, Singapuri A, Stanel SC, Thorpe M, Wootton DG, Yates T, Gisli Jenkins R, Singh SJ, Man WD, Brightling CE, Wain LV, Porter JC, Thompson AAR, Horsley A, Molyneaux PL, Evans RA, Jones SE, Rutter MK, Blaikley JF; PHOSP-COVID Study Collaborative Group. Jackson C, et al. Lancet Respir Med. 2023 Aug;11(8):673-684. doi: 10.1016/S2213-2600(23)00124-8. Epub 2023 Apr 15. Lancet Respir Med. 2023. PMID: 37072018 Free PMC article.
Validation of a Fully Automated Hybrid Deep Learning Cardiac Substructure Segmentation Tool for Contouring and Dose Evaluation in Lung Cancer Radiotherapy.
Chin V, Finnegan RN, Chlap P, Otton J, Haidar A, Holloway L, Thwaites DI, Dowling J, Delaney GP, Vinod SK. Chin V, et al. Among authors: holloway l. Clin Oncol (R Coll Radiol). 2023 Jun;35(6):370-381. doi: 10.1016/j.clon.2023.03.005. Epub 2023 Mar 11. Clin Oncol (R Coll Radiol). 2023. PMID: 36964031
This has promising applications in substructure dose calculations of large-scale datasets and for future studies on long-term cardiac toxicity....
This has promising applications in substructure dose calculations of large-scale datasets and for future studies on long-term cardiac …
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.
McAuley HJC, Evans RA, Bolton CE, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Greenhaff PL, Gupta A, Harris VC, Harrison EM, Ho LP, Horsley A, Houchen-Wolloff L, Jolley CJ, Leavy OC, Lone NI, Man WD, Marks M, Parekh D, Poinasamy K, Quint JK, Raman B, Richardson M, Saunders RM, Sereno M, Shikotra A, Singapuri A, Singh SJ, Steiner M, Tan AL, Wain LV, Welch C, Whitney J, Witham MD, Lord J, Greening NJ; PHOSP-COVID Study Collaborative Group. McAuley HJC, et al. EClinicalMedicine. 2023 Mar 11;57:101896. doi: 10.1016/j.eclinm.2023.101896. eCollection 2023 Mar. EClinicalMedicine. 2023. PMID: 36936404 Free PMC article.
BACKGROUND: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. ...
BACKGROUND: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes i …
Conformance of a 3T radiotherapy MRI scanner to the QIBA Diffusion Profile.
Carr ME, Keenan KE, Rai R, Boss MA, Metcalfe P, Walker A, Holloway L. Carr ME, et al. Among authors: holloway l. Med Phys. 2022 Jul;49(7):4508-4517. doi: 10.1002/mp.15645. Epub 2022 Apr 11. Med Phys. 2022. PMID: 35365884 Free PMC article.
Measurements of ADC %bias, coefficients of variation for short-/long-term repeatability and precision (CV(ST) /CV(LT) and CV(P) ), and b-value dependency (Dep(b) ) were calculated. ...
Measurements of ADC %bias, coefficients of variation for short-/long-term repeatability and precision (CV(ST) /CV(LT) and CV(P) ), an …
Will 'the feeling of abandonment' remain? Persisting impacts of the COVID-19 pandemic on rheumatology patients and clinicians.
Sloan M, Harwood R, Gordon C, Bosley M, Lever E, Modi R, Blane M, Brimicombe J, Barrere C, Holloway L, Sutton S, D'Cruz D. Sloan M, et al. Among authors: holloway l. Rheumatology (Oxford). 2022 Aug 30;61(9):3723-3736. doi: 10.1093/rheumatology/keab937. Rheumatology (Oxford). 2022. PMID: 34995345 Free PMC article. Clinical Trial.
Ratings for medical support, medical security and trust were significantly (P <0.001) positively correlated with patient WEMWBS and healthcare behaviours, and decreased during the pandemic. Healthcare-seeking was reduced, potentially long-term, including from patients f …
Ratings for medical support, medical security and trust were significantly (P <0.001) positively correlated with patient WEMWBS and healt …
Segmental Cardiac Radiation Dose Determines Magnitude of Regional Cardiac Dysfunction.
Trivedi SJ, Tang S, Byth K, Stefani L, Lo Q, Otton J, Jameson M, Tran D, Batumalai V, Holloway L, Delaney GP, Koh ES, Thomas L. Trivedi SJ, et al. Among authors: holloway l. J Am Heart Assoc. 2021 Apr 6;10(7):e019476. doi: 10.1161/JAHA.120.019476. Epub 2021 Mar 20. J Am Heart Assoc. 2021. PMID: 33749308 Free PMC article.
Radiotherapy-induced subclinical cardiac dysfunction is of importance because it could be additive to chemotherapy-related cardiotoxicity in patients with breast cancer. Long-term outcomes in patients with asymptomatic strain reduction require further investigation....
Radiotherapy-induced subclinical cardiac dysfunction is of importance because it could be additive to chemotherapy-related cardiotoxicity in …
Evaluation of the Post Stroke Checklist: a pilot study in the United Kingdom and Singapore.
Ward AB, Chen C, Norrving B, Gillard P, Walker MF, Blackburn S, Holloway L, Brainin M, Philp I; Global Stroke Community Advisory Panel (GSCAP). Ward AB, et al. Among authors: holloway l. Int J Stroke. 2014 Oct;9 Suppl A100:76-84. doi: 10.1111/ijs.12291. Epub 2014 Aug 4. Int J Stroke. 2014. PMID: 25088427 Free article.
BACKGROUND: There is currently no standardized process for long-term follow-up care. As a result, management of poststroke care varies greatly, and the needs of stroke survivors are not fully addressed. The Post Stroke Checklist was developed by the Global Stroke Community …
BACKGROUND: There is currently no standardized process for long-term follow-up care. As a result, management of poststroke care varie …
18 results