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Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial.
Higgins AM, Peake SL, Bellomo R, Cooper DJ, Delaney A, Harris AH, Howe BD, Nichol AD, Webb SA, Williams PJ; Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators and the ANZICS Clinical Trials Group. Higgins AM, et al. Crit Care Med. 2019 Jun;47(6):765-773. doi: 10.1097/CCM.0000000000003762. Crit Care Med. 2019. PMID: 30985391 Clinical Trial.
OBJECTIVES: To examine long-term survival and quality of life of patients with early septic shock. ...INTERVENTIONS: Early goal-directed therapy versus usual care. MEASUREMENTS AND MAIN RESULTS: Long-term survival was measured up to 12 months postrandomization. Heal …
OBJECTIVES: To examine long-term survival and quality of life of patients with early septic shock. ...INTERVENTIONS: Early goal-direc …
Predictive validity of the CriSTAL tool for short-term mortality in older people presenting at Emergency Departments: a prospective study.
Cardona M, Lewis ET, Kristensen MR, Skjøt-Arkil H, Ekmann AA, Nygaard HH, Jensen JJ, Jensen RO, Pedersen JL, Turner RM, Garden F, Alkhouri H, Asha S, Mackenzie J, Perkins M, Suri S, Holdgate A, Winoto L, Chang DCW, Gallego-Luxan B, McCarthy S, Petersen JA, Jensen BN, Backer Mogensen C, Hillman K, Brabrand M. Cardona M, et al. Among authors: holdgate a. Eur Geriatr Med. 2018;9(6):891-901. doi: 10.1007/s41999-018-0123-6. Epub 2018 Oct 31. Eur Geriatr Med. 2018. PMID: 30574216 Free PMC article.
Values for the Danish cohort were AUROC 0.764 with Fried and 0.794 using CFS. The most significant independent predictors of short-term death in both cohorts were advanced malignancy, frailty, male gender and advanced age. ...CONCLUSIONS: The modified CriSTAL tool (with CF …
Values for the Danish cohort were AUROC 0.764 with Fried and 0.794 using CFS. The most significant independent predictors of short-term …
Prospective Validation of a Checklist to Predict Short-term Death in Older Patients After Emergency Department Admission in Australia and Ireland.
Cardona M, O'Sullivan M, Lewis ET, Turner RM, Garden F, Alkhouri H, Asha S, Mackenzie J, Perkins M, Suri S, Holdgate A, Winoto L, Chang DCW, Gallego-Luxan B, McCarthy S, Hillman K, Breen D. Cardona M, et al. Among authors: holdgate a. Acad Emerg Med. 2019 Jun;26(6):610-620. doi: 10.1111/acem.13664. Epub 2018 Dec 14. Acad Emerg Med. 2019. PMID: 30428145 Free PMC article.
A minimum of five of 29 variables were sufficient for accurate prediction, and a cut point of 7+ or 6+ depending on the cohort was strongly indicative of risk of death. The most significant independent predictor of short-term death in both cohorts was frailty, carrying a t …
A minimum of five of 29 variables were sufficient for accurate prediction, and a cut point of 7+ or 6+ depending on the cohort was strongly …
Efficacy of a tool to predict short-term mortality in older people presenting at emergency departments: Protocol for a multi-centre cohort study.
Cardona M, Lewis ET, Turner RM, Alkhouri H, Asha S, Mackenzie J, Perkins M, Suri S, Holdgate A, Winoto L, Chang CW, Gallego-Luxan B, McCarthy S, Kristensen MR, O'Sullivan M, Skjøt-Arkil H, Ekmann AA, Nygaard HH, Jensen JJ, Jensen RO, Pedersen JL, Breen D, Petersen JA, Jensen BN, Mogensen CB, Hillman K, Brabrand M. Cardona M, et al. Among authors: holdgate a. Arch Gerontol Geriatr. 2018 May-Jun;76:169-174. doi: 10.1016/j.archger.2018.02.014. Epub 2018 Mar 6. Arch Gerontol Geriatr. 2018. PMID: 29524917
DISCUSSION: The CriSTAL checklist is an objective and practical tool for use in emergency departments among older patients to determine individual probability of death in the short-term. Its validation in this cohort is expected to reduce clinicians' prognostic uncertainty …
DISCUSSION: The CriSTAL checklist is an objective and practical tool for use in emergency departments among older patients to determine indi …
Systematic review of the relative efficacy of non-steroidal anti-inflammatory drugs and opioids in the treatment of acute renal colic.
Holdgate A, Pollock T. Holdgate A, et al. BMJ. 2004 Jun 12;328(7453):1401. doi: 10.1136/bmj.38119.581991.55. Epub 2004 Jun 3. BMJ. 2004. PMID: 15178585 Free PMC article. Review.
CONCLUSIONS: Patients receiving NSAIDs achieve greater reductions in pain scores and are less likely to require further analgesia in the short term than those receiving opioids. Opioids, particularly pethidine, are associated with a higher rate of vomiting....
CONCLUSIONS: Patients receiving NSAIDs achieve greater reductions in pain scores and are less likely to require further analgesia in the sho …