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CD19-CD28: An affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy.
Sam J, Hofer T, Kuettel C, Claus C, Thom J, Herter S, Georges G, Korfi K, Lechmann M, Eigenmann MJ, Marbach D, Jamois C, Lechner K, Krishnan SM, Gaillard BC, Marinho J, Kronenberg S, Kunz L, Wilson S, Briner S, Gebhardt S, Varol A, Appelt B, Nicolini VG, Speziale D, Bez M, Bommer E, Eckmann J, Hage C, Limani F, Jenni S, Schoenle A, Le Clech M, Vallier JB, Colombetti S, Bacac M, Gasser S, Klein C, Umaña P. Sam J, et al. Among authors: hofer t. Blood. 2024 Mar 4:blood.2023023381. doi: 10.1182/blood.2023023381. Online ahead of print. Blood. 2024. PMID: 38437725 Free article.
Notably, the triple combination of glofitamab with CD19-CD28 with the costimulatory 4-1BB agonist CD19-4-1BBL, offered substantially improved long-term tumor control over glofitamab monotherapy and respective duplet combinations. ...
Notably, the triple combination of glofitamab with CD19-CD28 with the costimulatory 4-1BB agonist CD19-4-1BBL, offered substantially improve …
Adopting Weight-Based Dosing With Pharmacy-Level Stewardship Strategies Could Reduce Cancer Drug Spending By Millions.
Bryant AK, Chopra Z, Edwards DM, Whalley AS, Bazzell BG, Moeller JA, Kelley MJ, Fendrick AM, Kerr EA, Ramnath N, Green MD, Hofer TP, Strohbehn GW. Bryant AK, et al. Among authors: hofer tp. Health Aff (Millwood). 2023 Jul;42(7):946-955. doi: 10.1377/hlthaff.2023.00102. Health Aff (Millwood). 2023. PMID: 37406228 Free PMC article.
Combining these operational innovations with value-based drug price negotiation enabled by recent policy changes may improve the long-term financial viability of cancer care in the US....
Combining these operational innovations with value-based drug price negotiation enabled by recent policy changes may improve the long-ter …
Antiviral CD8+ T-cell immune responses are impaired by cigarette smoke and in COPD.
Chen J, Wang X, Schmalen A, Haines S, Wolff M, Ma H, Zhang H, Stoleriu MG, Nowak J, Nakayama M, Bueno M, Brands J, Mora AL, Lee JS, Krauss-Etschmann S, Dmitrieva A, Frankenberger M, Hofer TP, Noessner E, Moosmann A, Behr J, Milger K, Deeg CA, Staab-Weijnitz CA, Hauck SM, Adler H, Goldmann T, Gaede KI, Behrends J, Kammerl IE, Meiners S. Chen J, et al. Among authors: hofer tp. Eur Respir J. 2023 Aug 3;62(2):2201374. doi: 10.1183/13993003.01374-2022. Print 2023 Aug. Eur Respir J. 2023. PMID: 37385655 Free PMC article.
CycleFlow simultaneously quantifies cell-cycle phase lengths and quiescence in vivo.
Jolly A, Fanti AK, Kongsaysak-Lengyel C, Claudino N, Gräßer I, Becker NB, Höfer T. Jolly A, et al. Among authors: hofer t. Cell Rep Methods. 2022 Oct 6;2(10):100315. doi: 10.1016/j.crmeth.2022.100315. eCollection 2022 Oct 24. Cell Rep Methods. 2022. PMID: 36313807 Free PMC article.
Inference is based on a mathematical model of the cell cycle, with realistic waiting time distributions for the G(1), S, and G(2)/M phases and a long-term quiescent G(0) state. We validate CycleFlow with an exponentially growing cancer cell line in vitro. ...
Inference is based on a mathematical model of the cell cycle, with realistic waiting time distributions for the G(1), S, and G(2)/M phases a …
Type 2 Diabetes Management, Control and Outcomes During the COVID-19 Pandemic in Older US Veterans: an Observational Study.
Aubert CE, Henderson JB, Kerr EA, Holleman R, Klamerus ML, Hofer TP. Aubert CE, et al. Among authors: hofer tp. J Gen Intern Med. 2022 Mar;37(4):870-877. doi: 10.1007/s11606-021-07301-7. Epub 2022 Jan 6. J Gen Intern Med. 2022. PMID: 34993873 Free PMC article.
CONCLUSION: Despite a shift to virtual visits and a decrease in A1c measurement during the pandemic, we observed no association with A1c level or short-term T2D-related outcomes, providing some reassurance about the adequacy of virtual visits. Further studies should assess …
CONCLUSION: Despite a shift to virtual visits and a decrease in A1c measurement during the pandemic, we observed no association with A1c lev …
A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity.
Das K, Belnoue E, Rossi M, Hofer T, Danklmaier S, Nolden T, Schreiber LM, Angerer K, Kimpel J, Hoegler S, Spiesschaert B, Kenner L, von Laer D, Elbers K, Derouazi M, Wollmann G. Das K, et al. Among authors: hofer t. Nat Commun. 2021 Aug 31;12(1):5195. doi: 10.1038/s41467-021-25506-6. Nat Commun. 2021. PMID: 34465781 Free PMC article.
Combining this heterologous vaccination with checkpoint blockade further improves therapeutic efficacy with long-term survival in the spectrum. Overall, heterologous vaccination with KISIMA and VSV-GP-TAA could sensitize non-inflamed tumors to checkpoint blockade therapy.. …
Combining this heterologous vaccination with checkpoint blockade further improves therapeutic efficacy with long-term survival in the …
Association of Genetic Testing Results With Mortality Among Women With Breast Cancer or Ovarian Cancer.
Kurian AW, Abrahamse P, Bondarenko I, Hamilton AS, Deapen D, Gomez SL, Morrow M, Berek JS, Hofer TP, Katz SJ, Ward KC. Kurian AW, et al. Among authors: hofer tp. J Natl Cancer Inst. 2022 Feb 7;114(2):245-253. doi: 10.1093/jnci/djab151. J Natl Cancer Inst. 2022. PMID: 34373918 Free PMC article.
CONCLUSIONS: Among breast cancer and ovarian cancer patients treated with chemotherapy in the community, BRCA1/2 and other gene PV carriers had equivalent or lower short-term cancer-specific mortality than noncarriers. These results may reassure newly diagnosed patients, a …
CONCLUSIONS: Among breast cancer and ovarian cancer patients treated with chemotherapy in the community, BRCA1/2 and other gene PV carriers …
Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes.
Esteve-Codina A, Hofer TP, Burggraf D, Heiss-Neumann MS, Gesierich W, Boland A, Olaso R, Bihoreau MT, Deleuze JF, Moeller W, Schmid O, Soler Artigas M, Renner K, Hohlfeld JM, Welte T, Fuehner T, Jerrentrup L, Koczulla AR, Greulich T, Prasse A, Müller-Quernheim J, Gupta S, Brightling C, Subramanian DR, Parr DG, Kolsum U, Gupta V, Barta I, Döme B, Strausz J, Stendardo M, Piattella M, Boschetto P, Korzybski D, Gorecka D, Nowinski A, Dabad M, Fernández-Callejo M, Endesfelder D, Zu Castell W, Hiemstra PS, Venge P, Noessner E, Griebel T, Heath S, Singh D, Gut I, Ziegler-Heitbrock L. Esteve-Codina A, et al. Among authors: hofer tp. Sci Rep. 2021 Jun 18;11(1):12848. doi: 10.1038/s41598-021-91742-x. Sci Rep. 2021. PMID: 34145303 Free PMC article.
Compared to healthy controls there were for males 40 differentially expressed genes (DEGs) and 73 DEGs for females with only 26 genes shared. The gene ontology (GO) term "response to bacterium" was shared, with several different DEGs contributing in males and females. ...F …
Compared to healthy controls there were for males 40 differentially expressed genes (DEGs) and 73 DEGs for females with only 26 genes shared …
Analysis of the Ordering Effects in Anthraquinone Thin Films and Its Potential Application for Sodium Ion Batteries.
Werner D, Apaydin DH, Wielend D, Geistlinger K, Saputri WD, Griesser UJ, Dražević E, Hofer TS, Portenkirchner E. Werner D, et al. Among authors: hofer ts. J Phys Chem C Nanomater Interfaces. 2021 Feb 25;125(7):3745-3757. doi: 10.1021/acs.jpcc.0c10778. Epub 2021 Feb 10. J Phys Chem C Nanomater Interfaces. 2021. PMID: 33815649 Free PMC article.
Our results show that AQ thin-film electrodes exhibit significantly better specific capacities (233 vs 87 mAh g(-1) in the first cycle), Coulombic efficiencies, and long-term cycling performance (80 vs 4 mAh g(-1) after 100 cycles) over the AQ powder electrodes. ...
Our results show that AQ thin-film electrodes exhibit significantly better specific capacities (233 vs 87 mAh g(-1) in the first cycle), Cou …
Telomerase therapy attenuates cardiotoxic effects of doxorubicin.
Chatterjee S, Hofer T, Costa A, Lu D, Batkai S, Gupta SK, Bolesani E, Zweigerdt R, Megias D, Streckfuss-Bömeke K, Brandenberger C, Thum T, Bär C. Chatterjee S, et al. Among authors: hofer t. Mol Ther. 2021 Apr 7;29(4):1395-1410. doi: 10.1016/j.ymthe.2020.12.035. Epub 2021 Jan 1. Mol Ther. 2021. PMID: 33388418 Free PMC article.
We used adeno-associated virus (AAV)-mediated gene therapy for long-term expression of telomerase in in vitro and in vivo models of doxorubicin-induced cardiotoxicity. ...
We used adeno-associated virus (AAV)-mediated gene therapy for long-term expression of telomerase in in vitro and in vivo models of d …
37 results