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Antigen-Clustered Nanovaccine Achieves Long-Term Tumor Remission by Promoting B/CD 4 T Cell Crosstalk.
Li C, Clauson R, Bugada LF, Ke F, He B, Yu Z, Chen H, Jacobovitz B, Hu H, Chuikov P, Hill BD, Rizvi SM, Song Y, Sun K, Axenov P, Huynh D, Wang X, Garmire L, Lei YL, Grigorova I, Wen F, Cascalho M, Gao W, Sun D. Li C, et al. Among authors: hill bd. ACS Nano. 2024 Apr 2;18(13):9584-9604. doi: 10.1021/acsnano.3c13038. Epub 2024 Mar 21. ACS Nano. 2024. PMID: 38513119
ACNVax not only remodeled the tumor immune microenvironment but also induced a long-term immune memory, as evidenced by complete rejection of tumor rechallenge and a high level of antigen-specific memory B, CD4, and CD8 cells in mice (>200 days). This study provides a c …
ACNVax not only remodeled the tumor immune microenvironment but also induced a long-term immune memory, as evidenced by complete reje …
Extracellular Matrix Scaffold-Assisted Tumor Vaccines Induce Tumor Regression and Long-Term Immune Memory.
Pal S, Chaudhari R, Baurceanu I, Hill BJ, Nagy BA, Wolf MT. Pal S, et al. Among authors: hill bj. Adv Mater. 2024 Apr;36(15):e2309843. doi: 10.1002/adma.202309843. Epub 2024 Feb 11. Adv Mater. 2024. PMID: 38302823
SIS-ECM scaffold-assisted vaccination prolonged antigen exposure is dependent on CD8(+) cytotoxic T cells and generates long-term antigen-specific immune memory for at least 10 months post-vaccination. ...
SIS-ECM scaffold-assisted vaccination prolonged antigen exposure is dependent on CD8(+) cytotoxic T cells and generates long-term ant …
Bridging therapy with axicabtagene ciloleucel for large B-cell lymphoma: results from the US Lymphoma CAR-T Consortium.
Jain MD, Jacobs MT, Gao F, Nastoupil LJ, Spiegel JY, Lin Y, Dahiya S, Lunning M, Lekakis L, Reagan P, Oluwole O, McGuirk J, Deol A, Sehgal AR, Goy A, Hill BT, Andreadis C, Munoz J, Chavez JC, Bennani NN, Rapoport AP, Vose JM, Miklos D, Neelapu SS, Locke FL, Ghobadi A. Jain MD, et al. Among authors: hill bt. Blood Adv. 2024 Feb 27;8(4):1042-1050. doi: 10.1182/bloodadvances.2023011489. Blood Adv. 2024. PMID: 38051550 Free PMC article.
Our findings suggest that BT may be safe without a significant impact on long-term survival for patients who require disease stabilization during the manufacturing period. ...
Our findings suggest that BT may be safe without a significant impact on long-term survival for patients who require disease stabiliz …
Co-designing a community lifestyle intervention program to reduce postpartum weight retention.
Makama M, Skouteris H, Moran LJ, Hill B, Redman LM, Lim S. Makama M, et al. Among authors: hill b. Health Expect. 2023 Nov 3;27(1):e13905. doi: 10.1111/hex.13905. Online ahead of print. Health Expect. 2023. PMID: 37920876 Free PMC article.
BACKGROUND: Postpartum weight retention is a major contributor to obesity in later life resulting in long-term health consequences in women. Postpartum lifestyle interventions are known to be effective in reducing postpartum weight retention and improving the overall healt …
BACKGROUND: Postpartum weight retention is a major contributor to obesity in later life resulting in long-term health consequences in …
Population genomic diversity and structure in the golden bandicoot: a history of isolation, extirpation, and conservation.
Rick K, Byrne M, Cameron S, Cooper SJB, Dunlop J, Hill B, Lohr C, Mitchell NJ, Moritz C, Travouillon KJ, von Takach B, Ottewell K. Rick K, et al. Among authors: hill b. Heredity (Edinb). 2023 Dec;131(5-6):374-386. doi: 10.1038/s41437-023-00653-2. Epub 2023 Oct 8. Heredity (Edinb). 2023. PMID: 37806995 Free PMC article.
These clusters exhibited substantial genetic differentiation (pairwise F(ST) values ranging from 0.18 to 0.65, pairwise D(XY) ranging from 0.1 to 0.168), reflecting long-term isolation of some populations on offshore islands and the influence of genetic drift. ...
These clusters exhibited substantial genetic differentiation (pairwise F(ST) values ranging from 0.18 to 0.65, pairwise D(XY) ranging from 0 …
Long-Term Effect of Switching From an Anti-CGRP Receptor to an Anti-CGRP Ligand Antibody in Treatment-Refractory Chronic Migraine: A Prospective Real-World Analysis.
Lambru G, Caponnetto V, Hill B, Ratti S, Sacco S, Murphy M, Briscoe J, Andreou AP. Lambru G, et al. Among authors: hill b. Neurotherapeutics. 2023 Sep;20(5):1284-1293. doi: 10.1007/s13311-023-01394-0. Epub 2023 Jul 10. Neurotherapeutics. 2023. PMID: 37430146 Free PMC article.
In migraine patients with a poor response to a calcitonin gene-related peptide monoclonal antibody against the receptor, switching to a calcitonin gene-related peptide monoclonal antibodies against the ligand may be beneficial. This was a long-term real-world prospective a …
In migraine patients with a poor response to a calcitonin gene-related peptide monoclonal antibody against the receptor, switching to a calc …
Survival with Axicabtagene Ciloleucel in Large B-Cell Lymphoma.
Westin JR, Oluwole OO, Kersten MJ, Miklos DB, Perales MA, Ghobadi A, Rapoport AP, Sureda A, Jacobson CA, Farooq U, van Meerten T, Ulrickson M, Elsawy M, Leslie LA, Chaganti S, Dickinson M, Dorritie K, Reagan PM, McGuirk J, Song KW, Riedell PA, Minnema MC, Yang Y, Vardhanabhuti S, Filosto S, Cheng P, Shahani SA, Schupp M, To C, Locke FL; ZUMA-7 Investigators; Kite Members. Westin JR, et al. N Engl J Med. 2023 Jul 13;389(2):148-157. doi: 10.1056/NEJMoa2301665. Epub 2023 Jun 5. N Engl J Med. 2023. PMID: 37272527 Clinical Trial.
BACKGROUND: In an analysis of the primary outcome of this phase 3 trial, patients with early relapsed or refractory large B-cell lymphoma who received axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor T-cell therapy, as second-line treatment had …
BACKGROUND: In an analysis of the primary outcome of this phase 3 trial, patients with early relapsed or refractory large B-cell lymphoma wh …
Population genomics and conservation management of the threatened black-footed tree-rat (Mesembriomys gouldii) in northern Australia.
von Takach B, Sargent H, Penton CE, Rick K, Murphy BP, Neave G, Davies HF, Hill BM, Banks SC. von Takach B, et al. Among authors: hill bm. Heredity (Edinb). 2023 May;130(5):278-288. doi: 10.1038/s41437-023-00601-0. Epub 2023 Mar 10. Heredity (Edinb). 2023. PMID: 36899176 Free PMC article.
Here, we describe the range-wide population genomic structure of a threatened Australian rodent, the black-footed tree-rat (Mesembriomys gouldii), aiming to provide insight into the timing and extent of population declines across a large region with a dearth of long-term m …
Here, we describe the range-wide population genomic structure of a threatened Australian rodent, the black-footed tree-rat (Mesembriomys gou …
Two-year effectiveness of erenumab in resistant chronic migraine: a prospective real-world analysis.
Andreou AP, Fuccaro M, Hill B, Murphy M, Caponnetto V, Kilner R, Lambru G. Andreou AP, et al. Among authors: hill b. J Headache Pain. 2022 Nov 4;23(1):139. doi: 10.1186/s10194-022-01507-8. J Headache Pain. 2022. PMID: 36333710 Free PMC article.
By month 6, 13% of patients discontinued the treatment because of side effects, often constipation. CONCLUSIONS: Long-term sustained effectiveness of erenumab was reported only by a minority of resistant CM patients. Although more research in resistant migraine is needed, …
By month 6, 13% of patients discontinued the treatment because of side effects, often constipation. CONCLUSIONS: Long-term sustained …
Population genomics of a predatory mammal reveals patterns of decline and impacts of exposure to toxic toads.
von Takach B, Ranjard L, Burridge CP, Cameron SF, Cremona T, Eldridge MDB, Fisher DO, Frankenberg S, Hill BM, Hohnen R, Jolly CJ, Kelly E, MacDonald AJ, Moussalli A, Ottewell K, Phillips BL, Radford IJ, Spencer PBS, Trewella GJ, Umbrello LS, Banks SC. von Takach B, et al. Among authors: hill bm. Mol Ecol. 2022 Nov;31(21):5468-5486. doi: 10.1111/mec.16680. Epub 2022 Sep 25. Mol Ecol. 2022. PMID: 36056907 Free PMC article.
We found strong heterogeneity in the distribution of genomic diversity across the continent, characterized by (i) biogeographical barriers driving hierarchical population structure through long-term isolation, and (ii) severe reductions in diversity resulting from populati …
We found strong heterogeneity in the distribution of genomic diversity across the continent, characterized by (i) biogeographical barriers d …
117 results