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The risk of drug resistance during long-acting antimicrobial therapy.
Nande A, Hill AL. Nande A, et al. Among authors: hill al. Proc Biol Sci. 2022 Nov 9;289(1986):20221444. doi: 10.1098/rspb.2022.1444. Epub 2022 Nov 9. Proc Biol Sci. 2022. PMID: 36350211 Free PMC article.
The emergence of drug resistance during antimicrobial therapy is a major global health problem, especially for chronic infections like human immunodeficiency virus, hepatitis B and C, and tuberculosis. Sub-optimal adherence to long-term treatment is an important contributo …
The emergence of drug resistance during antimicrobial therapy is a major global health problem, especially for chronic infections like human …
The United States COVID-19 Forecast Hub dataset.
Cramer EY, Huang Y, Wang Y, Ray EL, Cornell M, Bracher J, Brennen A, Rivadeneira AJC, Gerding A, House K, Jayawardena D, Kanji AH, Khandelwal A, Le K, Mody V, Mody V, Niemi J, Stark A, Shah A, Wattanchit N, Zorn MW, Reich NG; US COVID-19 Forecast Hub Consortium. Cramer EY, et al. Sci Data. 2022 Aug 1;9(1):462. doi: 10.1038/s41597-022-01517-w. Sci Data. 2022. PMID: 35915104 Free PMC article.
The goal of this dataset is to establish a standardized and comparable set of short-term forecasts from modeling teams. These data can be used to develop ensemble models, communicate forecasts to the public, create visualizations, compare models, and inform policies regard …
The goal of this dataset is to establish a standardized and comparable set of short-term forecasts from modeling teams. These data ca …
Evaluation of individual and ensemble probabilistic forecasts of COVID-19 mortality in the United States.
Cramer EY, Ray EL, Lopez VK, Bracher J, Brennen A, Castro Rivadeneira AJ, Gerding A, Gneiting T, House KH, Huang Y, Jayawardena D, Kanji AH, Khandelwal A, Le K, Mühlemann A, Niemi J, Shah A, Stark A, Wang Y, Wattanachit N, Zorn MW, Gu Y, Jain S, Bannur N, Deva A, Kulkarni M, Merugu S, Raval A, Shingi S, Tiwari A, White J, Abernethy NF, Woody S, Dahan M, Fox S, Gaither K, Lachmann M, Meyers LA, Scott JG, Tec M, Srivastava A, George GE, Cegan JC, Dettwiller ID, England WP, Farthing MW, Hunter RH, Lafferty B, Linkov I, Mayo ML, Parno MD, Rowland MA, Trump BD, Zhang-James Y, Chen S, Faraone SV, Hess J, Morley CP, Salekin A, Wang D, Corsetti SM, Baer TM, Eisenberg MC, Falb K, Huang Y, Martin ET, McCauley E, Myers RL, Schwarz T, Sheldon D, Gibson GC, Yu R, Gao L, Ma Y, Wu D, Yan X, Jin X, Wang YX, Chen Y, Guo L, Zhao Y, Gu Q, Chen J, Wang L, Xu P, Zhang W, Zou D, Biegel H, Lega J, McConnell S, Nagraj VP, Guertin SL, Hulme-Lowe C, Turner SD, Shi Y, Ban X, Walraven R, Hong QJ, Kong S, van de Walle A, Turtle JA, Ben-Nun M, Riley S, Riley P, Koyluoglu U, DesRoches D, Forli P, Hamory B, Kyriakides C, Leis H, Milliken J, Moloney M, Morgan J, Nirgudkar N, Ozcan G, Piwonka N, Ravi M, Schrader C… See abstract for full author list ➔ Cramer EY, et al. Among authors: hill al. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2113561119. doi: 10.1073/pnas.2113561119. Epub 2022 Apr 8. Proc Natl Acad Sci U S A. 2022. PMID: 35394862 Free PMC article.
Short-term probabilistic forecasts of the trajectory of the COVID-19 pandemic in the United States have served as a visible and important communication channel between the scientific modeling community and both the general public and decision-makers. Forecasting models pro …
Short-term probabilistic forecasts of the trajectory of the COVID-19 pandemic in the United States have served as a visible and impor …
Population structure across scales facilitates coexistence and spatial heterogeneity of antibiotic-resistant infections.
Krieger MS, Denison CE, Anderson TL, Nowak MA, Hill AL. Krieger MS, et al. Among authors: hill al. PLoS Comput Biol. 2020 Jul 6;16(7):e1008010. doi: 10.1371/journal.pcbi.1008010. eCollection 2020 Jul. PLoS Comput Biol. 2020. PMID: 32628660 Free PMC article.
Antibiotic-resistant infections are a growing threat to human health, but basic features of the eco-evolutionary dynamics remain unexplained. Most prominently, there is no clear mechanism for the long-term coexistence of both drug-sensitive and resistant strains at interme …
Antibiotic-resistant infections are a growing threat to human health, but basic features of the eco-evolutionary dynamics remain unexplained …
Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report.
Gupta RK, Peppa D, Hill AL, Gálvez C, Salgado M, Pace M, McCoy LE, Griffith SA, Thornhill J, Alrubayyi A, Huyveneers LEP, Nastouli E, Grant P, Edwards SG, Innes AJ, Frater J, Nijhuis M, Wensing AMJ, Martinez-Picado J, Olavarria E. Gupta RK, et al. Among authors: hill al. Lancet HIV. 2020 May;7(5):e340-e347. doi: 10.1016/S2352-3018(20)30069-2. Epub 2020 Mar 10. Lancet HIV. 2020. PMID: 32169158 Free PMC article.
BACKGROUND: The London patient (participant 36 in the IciStem cohort) underwent allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5delta32/delta32); remission was reported at 18 months after analytical treatment interruption (ATI). Here, we present lon …
BACKGROUND: The London patient (participant 36 in the IciStem cohort) underwent allogeneic stem-cell transplantation with cells that did not …
Dynamics of bed bug infestations and control under disclosure policies.
Xie S, Hill AL, Rehmann CR, Levy MZ. Xie S, et al. Among authors: hill al. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6473-6481. doi: 10.1073/pnas.1814647116. Epub 2019 Mar 4. Proc Natl Acad Sci U S A. 2019. PMID: 30833386 Free PMC article.
We find disclosure to be an effective control policy to curb infestation prevalence. Over the short term (within 5 years), disclosure policies result in modest increases in cost to landlords, while over the long term, reductions of infestation prevalence lead, on av …
We find disclosure to be an effective control policy to curb infestation prevalence. Over the short term (within 5 years), disclosure …
Insight into treatment of HIV infection from viral dynamics models.
Hill AL, Rosenbloom DIS, Nowak MA, Siliciano RF. Hill AL, et al. Immunol Rev. 2018 Sep;285(1):9-25. doi: 10.1111/imr.12698. Immunol Rev. 2018. PMID: 30129208 Free PMC article. Review.
This includes studies of the multiphasic decay of viral load when antiretroviral therapy is given, the evolution of drug resistance, the long-term persistence latently infected cells, and the rebound of viremia when drugs are stopped. ...
This includes studies of the multiphasic decay of viral load when antiretroviral therapy is given, the evolution of drug resistance, the lon …
Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance.
Moreno-Gamez S, Hill AL, Rosenbloom DI, Petrov DA, Nowak MA, Pennings PS. Moreno-Gamez S, et al. Among authors: hill al. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2874-83. doi: 10.1073/pnas.1424184112. Epub 2015 May 18. Proc Natl Acad Sci U S A. 2015. PMID: 26038564 Free PMC article.
Although this strategy generally has significant benefits over monotherapy, it may also select for multidrug-resistant strains, particularly during long-term treatment for chronic infections. Infections with these strains present an important clinical and public health pro …
Although this strategy generally has significant benefits over monotherapy, it may also select for multidrug-resistant strains, particularly …
Beliefs and practices of obstetric care providers regarding umbilical cord clamping.
Hill AL, Fontenot HB. Hill AL, et al. Nurs Womens Health. 2014 Oct-Nov;18(5):413-9. doi: 10.1111/1751-486X.12149. Nurs Womens Health. 2014. PMID: 25316541
The optimal timing for umbilical cord clamping after birth has yet to be established, and controversy exists. There is evidence of potentially significant health benefits of delayed cord clamping for both full-term and preterm newborns, but this practice has not bee …
The optimal timing for umbilical cord clamping after birth has yet to be established, and controversy exists. There is evidence of po …
17 results