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Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures.
Jubelin C, Muñoz-Garcia J, Ollivier E, Cochonneau D, Vallette F, Heymann MF, Oliver L, Heymann D. Jubelin C, et al. Among authors: heymann d. Biochim Biophys Acta Mol Cell Res. 2024 Mar;1871(3):119660. doi: 10.1016/j.bbamcr.2024.119660. Epub 2024 Jan 10. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 38216092 Free article.
Dormancy was studied by staining cancer cells with a lipophilic dye (DiD), and long-term DiD(+) cells were considered as dormant cancer cells. The role of the extracellular matrix in inducing dormancy was investigated by embedding cells into methylcellulose or Geltrex. ...
Dormancy was studied by staining cancer cells with a lipophilic dye (DiD), and long-term DiD(+) cells were considered as dormant canc …
High glucose exposure drives intestinal barrier dysfunction by altering its morphological, structural and functional properties.
Dubois N, Muñoz-Garcia J, Heymann D, Renodon-Cornière A. Dubois N, et al. Among authors: heymann d. Biochem Pharmacol. 2023 Oct;216:115765. doi: 10.1016/j.bcp.2023.115765. Epub 2023 Aug 22. Biochem Pharmacol. 2023. PMID: 37619641
In our study, we used in vitro models composed of Caco-2 and/or HT29-MTX cells in both monoculture and co-culture to assess the effects of long-term HG exposure on the morphological, structural, and functional properties of the intestinal barrier. ...
In our study, we used in vitro models composed of Caco-2 and/or HT29-MTX cells in both monoculture and co-culture to assess the effects of l …
Mpox neglect and the smallpox niche: a problem for Africa, a problem for the world.
Adetifa I, Muyembe JJ, Bausch DG, Heymann DL. Adetifa I, et al. Among authors: heymann dl. Lancet. 2023 May 27;401(10390):1822-1824. doi: 10.1016/S0140-6736(23)00588-3. Epub 2023 May 2. Lancet. 2023. PMID: 37146622 Free PMC article. Review.
Although there has been much attention on the global outbreak, most of the focus has been on high-income countries outside of Africa, despite the fact that monkeypox virus has been causing disease in parts of Africa for at least 50 years. Furthermore, the long-term consequ …
Although there has been much attention on the global outbreak, most of the focus has been on high-income countries outside of Africa, despit …
Osteosarcoma.
Beird HC, Bielack SS, Flanagan AM, Gill J, Heymann D, Janeway KA, Livingston JA, Roberts RD, Strauss SJ, Gorlick R. Beird HC, et al. Among authors: heymann d. Nat Rev Dis Primers. 2022 Dec 8;8(1):77. doi: 10.1038/s41572-022-00409-y. Nat Rev Dis Primers. 2022. PMID: 36481668 Review.
Survivors of osteosarcoma require specialized medical follow-up, as curative treatment consisting of chemotherapy and surgery has long-term adverse effects, which also affect the quality of life of patients. ...
Survivors of osteosarcoma require specialized medical follow-up, as curative treatment consisting of chemotherapy and surgery has long-te …
Design and validation of a tunable inertial microfluidic system for the efficient enrichment of circulating tumor cells in blood.
Rodríguez-Pena A, Armendariz E, Oyarbide A, Morales X, Ortiz-Espinosa S, Ruiz-Fernández de Córdoba B, Cochonneau D, Cornago I, Heymann D, Argemi J, D'Avola D, Sangro B, Lecanda F, Pio R, Cortés-Domínguez I, Ortiz-de-Solórzano C. Rodríguez-Pena A, et al. Among authors: heymann d. Bioeng Transl Med. 2022 Apr 29;7(3):e10331. doi: 10.1002/btm2.10331. eCollection 2022 Sep. Bioeng Transl Med. 2022. PMID: 36176621 Free PMC article.
We designed the device based on computer simulations that introduce a novel, customized inertial force term, and provide practical fabrication guidelines. We validated the device using calibration beads, which allowed us to refine the simulations and redesign the device. . …
We designed the device based on computer simulations that introduce a novel, customized inertial force term, and provide practical fa …
Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells.
Guyon N, Garnier D, Briand J, Nadaradjane A, Bougras-Cartron G, Raimbourg J, Campone M, Heymann D, Vallette FM, Frenel JS, Cartron PF. Guyon N, et al. Among authors: heymann d. Cell Death Dis. 2020 Dec 11;11(12):1048. doi: 10.1038/s41419-020-03224-z. Cell Death Dis. 2020. PMID: 33311449 Free PMC article.
However, resistance to anti-PD1 antibodies often decreases the long-term therapeutic benefits. Despite this observation in clinical practice, the molecular mechanisms associated with resistance to anti-PD1 antibody therapy have not yet been elucidated. ...
However, resistance to anti-PD1 antibodies often decreases the long-term therapeutic benefits. Despite this observation in clinical p …
Lessons learnt from easing COVID-19 restrictions: an analysis of countries and regions in Asia Pacific and Europe.
Han E, Tan MMJ, Turk E, Sridhar D, Leung GM, Shibuya K, Asgari N, Oh J, García-Basteiro AL, Hanefeld J, Cook AR, Hsu LY, Teo YY, Heymann D, Clark H, McKee M, Legido-Quigley H. Han E, et al. Among authors: heymann d. Lancet. 2020 Nov 7;396(10261):1525-1534. doi: 10.1016/S0140-6736(20)32007-9. Epub 2020 Sep 24. Lancet. 2020. PMID: 32979936 Free PMC article. Review.
However, lockdowns and other extreme restrictions cannot be sustained for the long term in the hope that there will be an effective vaccine or treatment for COVID-19. ...
However, lockdowns and other extreme restrictions cannot be sustained for the long term in the hope that there will be an effective v …
Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro.
Leveque X, Hochane M, Geraldo F, Dumont S, Gratas C, Oliver L, Gaignier C, Trichet V, Layrolle P, Heymann D, Herault O, Vallette FM, Olivier C. Leveque X, et al. Among authors: heymann d. Stem Cells. 2019 Aug;37(8):1083-1094. doi: 10.1002/stem.3014. Epub 2019 Apr 17. Stem Cells. 2019. PMID: 30977188 Free PMC article.
Our goal was to evaluate if the prolonged exposure to pesticide mixture could accelerate aging-related markers and in particular deteriorate the immunosuppressive properties of MSCs. MSCs exposed to pesticide mixture, under long-term culture and obtained from aging donor, …
Our goal was to evaluate if the prolonged exposure to pesticide mixture could accelerate aging-related markers and in particular deteriorate …
Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A.
de Ridder D, Marino S, Bishop RT, Renema N, Chenu C, Heymann D, Idris AI. de Ridder D, et al. Among authors: heymann d. Sci Rep. 2018 May 2;8(1):6877. doi: 10.1038/s41598-018-25290-2. Sci Rep. 2018. PMID: 29720701 Free PMC article.
However, inhibition of bone formation associated with continuous exposure to Sema3A may limit its long-term usefulness as therapeutic agent....
However, inhibition of bone formation associated with continuous exposure to Sema3A may limit its long-term usefulness as therapeutic …
Severe compromise of preosteoblasts in a surgical mouse model of bisphosphonate-associated osteonecrosis of the jaw.
Córdova LA, Guilbaud F, Amiaud J, Battaglia S, Charrier C, Lezot F, Piot B, Redini F, Heymann D. Córdova LA, et al. Among authors: heymann d. J Craniomaxillofac Surg. 2016 Sep;44(9):1387-94. doi: 10.1016/j.jcms.2016.07.015. Epub 2016 Jul 22. J Craniomaxillofac Surg. 2016. PMID: 27519659 Free article.
Alveolar sockets were assessed at both 3 weeks (intermediate) and 9 weeks (long-term) after molar extraction by semi-quantitative histomorphometry for empty lacunae, preosteoblasts (Osterix), osteoclasts (TRAP), and pericyte-like cells (CD146). ...Furthermore, the number o …
Alveolar sockets were assessed at both 3 weeks (intermediate) and 9 weeks (long-term) after molar extraction by semi-quantitative his …
31 results