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Page 1
Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy.
Claessen G, De Bosscher R, Janssens K, Young P, Dausin C, Claeys M, Claus P, Goetschalckx K, Bogaert J, Mitchell AM, Flannery MD, Elliott AD, Yu C, Ghekiere O, Robyns T, Van De Heyning CM, Sanders P, Kalman JM, Ohanian M, Soka M, Rath E, Giannoulatou E, Johnson R, Lacaze P, Herbots L, Willems R, Fatkin D, Heidbuchel H, La Gerche A; Pro@Heart Consortium. Claessen G, et al. Circulation. 2023 Dec 18. doi: 10.1161/CIRCULATIONAHA.122.063777. Online ahead of print. Circulation. 2023. PMID: 38109351 Free article.
Genetic and imaging markers may help identify endurance athletes in whom scrutiny about long-term clinical outcomes may be appropriate. REGISTRATION: URL: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?...
Genetic and imaging markers may help identify endurance athletes in whom scrutiny about long-term clinical outcomes may be appropriat …
Effect of acute environmental hypoxia on protein metabolism in human skeletal muscle.
D'Hulst G, Jamart C, Van Thienen R, Hespel P, Francaux M, Deldicque L. D'Hulst G, et al. Among authors: hespel p. Acta Physiol (Oxf). 2013 Jul;208(3):251-64. doi: 10.1111/apha.12086. Epub 2013 Mar 25. Acta Physiol (Oxf). 2013. PMID: 23418947 Free article. Clinical Trial.
CONCLUSION: Contrary to our hypothesis and despite an increase in the mRNA level of Redd1, an inhibitor of the mTORC1 pathway, short-term acute environmental hypoxia induced a higher response of PKB and S6K1 to a meal, which may be due to increased plasma insulin concentra …
CONCLUSION: Contrary to our hypothesis and despite an increase in the mRNA level of Redd1, an inhibitor of the mTORC1 pathway, short-term …
Dietary nitrate improves muscle but not cerebral oxygenation status during exercise in hypoxia.
Masschelein E, Van Thienen R, Wang X, Van Schepdael A, Thomis M, Hespel P. Masschelein E, et al. Among authors: hespel p. J Appl Physiol (1985). 2012 Sep 1;113(5):736-45. doi: 10.1152/japplphysiol.01253.2011. Epub 2012 Jul 5. J Appl Physiol (1985). 2012. PMID: 22773768 Free article. Clinical Trial.

Hypoxia reduced time to exhaustion in EX(max) by 36% (P < 0.05), but this ergolytic effect was partly negated by BR (+5%, P < 0.05). Short-term dietary nitrate supplementation improves arterial and muscle oxygenation status but not cerebral oxygenation status during

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Hypoxia reduced time to exhaustion in EX(max) by 36% (P < 0.05), but this ergolytic effect was partly negated by BR (+5%, P < 0.05). S

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Hyperglycemic diet and training alter insulin sensitivity, intramyocellular lipid content but not UCP3 protein expression in rat skeletal muscles.
Vaisy M, Szlufcik K, Maris M, De Bock K, Hesselink MK, Eijnde BO, Schrauwen P, Hespel P. Vaisy M, et al. Among authors: hespel p. Int J Mol Med. 2010 Jun;25(6):905-13. doi: 10.3892/ijmm_00000421. Int J Mol Med. 2010. PMID: 20428795
These findings indicate that changes in IMCL content but not UCP3 content are implicated in short-term effects of cafeteria-style diet and exercise training on muscular insulin sensitivity in rats....
These findings indicate that changes in IMCL content but not UCP3 content are implicated in short-term effects of cafeteria-style die …
Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake.
De Bock K, Derave W, Eijnde BO, Hesselink MK, Koninckx E, Rose AJ, Schrauwen P, Bonen A, Richter EA, Hespel P. De Bock K, et al. Among authors: hespel p. J Appl Physiol (1985). 2008 Apr;104(4):1045-55. doi: 10.1152/japplphysiol.01195.2007. Epub 2008 Feb 14. J Appl Physiol (1985). 2008. PMID: 18276898 Free article.
Neither IMCL breakdown (P = 0.23) nor fat oxidation rates during exercise were altered by training. Thus short-term training elicits similar adaptations in peak Vo(2) whether carried out in the fasted or carbohydrate-fed state. ...
Neither IMCL breakdown (P = 0.23) nor fat oxidation rates during exercise were altered by training. Thus short-term training elicits …
Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans.
Derave W, Marescau B, Vanden Eede E, Eijnde BO, De Deyn PP, Hespel P. Derave W, et al. Among authors: hespel p. J Appl Physiol (1985). 2004 Sep;97(3):852-7. doi: 10.1152/japplphysiol.00206.2004. Epub 2004 Apr 23. J Appl Physiol (1985). 2004. PMID: 15107411 Free article. Clinical Trial.
The aim of the present study was to investigate the metabolic consequences of a frequently used, long-term creatine ingestion protocol on the circulating creatine synthesis precursor molecules, guanidinoacetate and arginine, and their related guanidino compounds. ...
The aim of the present study was to investigate the metabolic consequences of a frequently used, long-term creatine ingestion protoco …
Creatine supplementation in health and disease: what is the evidence for long-term efficacy?
Derave W, Eijnde BO, Hespel P. Derave W, et al. Among authors: hespel p. Mol Cell Biochem. 2003 Feb;244(1-2):49-55. Mol Cell Biochem. 2003. PMID: 12701809 Review.
Creatine supplementation is an established ergogenic aid in sports and is now claimed to have therapeutical applications in a variety of diseases. The available literature mainly covers the short-term (one to several weeks) effects of creatine supplementation on skeletal m …
Creatine supplementation is an established ergogenic aid in sports and is now claimed to have therapeutical applications in a variety of dis …
Effects of creatine supplementation and exercise training on fitness in men 55-75 yr old.
Eijnde BO, Van Leemputte M, Goris M, Labarque V, Taes Y, Verbessem P, Vanhees L, Ramaekers M, Vanden Eynde B, Van Schuylenbergh R, Dom R, Richter EA, Hespel P. Eijnde BO, et al. Among authors: hespel p. J Appl Physiol (1985). 2003 Aug;95(2):818-28. doi: 10.1152/japplphysiol.00891.2002. Epub 2003 Mar 28. J Appl Physiol (1985). 2003. PMID: 12665537 Free article. Clinical Trial.
Furthermore, the other measurements were not affected by CR. It is concluded that long-term creatine intake (5 g/day) in conjunction with exercise training does not beneficially impact physical fitness in men between 55 and 75 yr of age....
Furthermore, the other measurements were not affected by CR. It is concluded that long-term creatine intake (5 g/day) in conjunction …
Opposite actions of caffeine and creatine on muscle relaxation time in humans.
Hespel P, Op't Eijnde B, Van Leemputte M. Hespel P, et al. J Appl Physiol (1985). 2002 Feb;92(2):513-8. doi: 10.1152/japplphysiol.00255.2001. J Appl Physiol (1985). 2002. PMID: 11796658 Free article. Clinical Trial.
According to a double-blind randomized crossover design, subjects (n = 10) performed the exercise test before (pretest) and after (posttest) creatine supplementation (Cr, 4 x 5 g/day, 4 days), short-term caffeine intake (Caf, 5 mg x kg(-1) x day(-1), 3 days), creatine supp …
According to a double-blind randomized crossover design, subjects (n = 10) performed the exercise test before (pretest) and after (posttest) …
Effect of creatine supplementation on creatine and glycogen content in rat skeletal muscle.
Eijnde BO, Richter EA, Henquin JC, Kiens B, Hespel P. Eijnde BO, et al. Among authors: hespel p. Acta Physiol Scand. 2001 Feb;171(2):169-76. doi: 10.1046/j.1365-201x.2001.00786.x. Acta Physiol Scand. 2001. PMID: 11350277

Furthermore, high dose creatine feeding raised (P < 0.05) plasma creatine concentration fivefold but did not alter circulating insulin level. It is concluded that short-term high dose creatine feeding enhances creatine disposal and glycogen storage in rat skeletal muscl

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Furthermore, high dose creatine feeding raised (P < 0.05) plasma creatine concentration fivefold but did not alter circulating insulin le

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20 results