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A randomised controlled trial in preterm infants comparing prophylactic with selective "less invasive surfactant administration" (pro.LISA).
Göpel W, Rausch TK, Mitschdörfer B, Mader S, Herting E, König IR, Stichtenoth G; pro.LISA study group. Göpel W, et al. Among authors: herting e. Trials. 2023 Sep 26;24(1):612. doi: 10.1186/s13063-023-07603-7. Trials. 2023. PMID: 37752593 Free PMC article. Clinical Trial.
Secondary endpoints include additional lung function parameters, endurance, motor development, intelligence, and sensitivity for infectious lung diseases. Short-term safety assessment will be done after completed enrolment (n = 698) and discharge of all infants. This safet …
Secondary endpoints include additional lung function parameters, endurance, motor development, intelligence, and sensitivity for infectious …
Increased Expression of Anaphylatoxin C5a-Receptor-1 in Neutrophils and Natural Killer Cells of Preterm Infants.
Boeckel H, Karsten CM, Göpel W, Herting E, Rupp J, Härtel C, Hartz A. Boeckel H, et al. Among authors: herting e. Int J Mol Sci. 2023 Jun 19;24(12):10321. doi: 10.3390/ijms241210321. Int J Mol Sci. 2023. PMID: 37373467 Free PMC article.
Via flow cytometry, we analyzed the expression pattern of C5a receptors on immune cells isolated from peripheral blood of preterm infants (n = 32) compared to those of their mothers (n = 25). Term infants and healthy adults served as controls. Preterm infants had a higher …
Via flow cytometry, we analyzed the expression pattern of C5a receptors on immune cells isolated from peripheral blood of preterm infants (n …
Antimicrobial skin peptides in premature infants: Comparison with term infants and impact of perinatal factors.
Humberg A, Neuenburg L, Boeckel H, Fortmann MI, Härtel C, Herting E, Hinrichs H, Rademacher F, Harder J. Humberg A, et al. Among authors: herting e. Front Immunol. 2023 Feb 27;14:1093340. doi: 10.3389/fimmu.2023.1093340. eCollection 2023. Front Immunol. 2023. PMID: 36923410 Free PMC article.

Samples were taken from preterm infants < 34 0/7 weeks gestational age (mean SD gestational age, 28.8 2.4 weeks) on days 0, 7, 14, and 28 after birth. Term infants (> 36 6/7 weeks) (controls) were washed on days 0 and 28. ...RNase 7 was more expressed in te

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Samples were taken from preterm infants < 34 0/7 weeks gestational age (mean SD gestational age, 28.8 2.4 weeks) on days 0, 7, 14, and 28

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Group A streptococcal disease in paediatric inpatients: a European perspective.
Boeddha NP, Atkins L, de Groot R, Driessen G, Hazelzet J, Zenz W, Carrol ED, Anderson ST, Martinon-Torres F, Agyeman PKA, Galassini R, Herberg J, Levin M, Schlapbach LJ, Emonts M; EUCLIDS consortium. Boeddha NP, et al. Eur J Pediatr. 2023 Feb;182(2):697-706. doi: 10.1007/s00431-022-04718-y. Epub 2022 Nov 30. Eur J Pediatr. 2023. PMID: 36449079 Free PMC article.
CONCLUSION: In an era of observed marked reduction in vaccine-preventable infections, GAS infection requiring hospital admission is still associated with significant severe disease in younger children, and short- and long-term morbidity. Further advances are required in th …
CONCLUSION: In an era of observed marked reduction in vaccine-preventable infections, GAS infection requiring hospital admission is still as …
Recurrent Late-Onset Sepsis in Extremely Low Birth Weight Infants Is Associated with Motor Deficits in Early School Age.
Humberg A, Fortmann MI, Spiegler J, Rausch TK, Siller B, Silwedel C, Marissen J, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN). Humberg A, et al. Among authors: herting e. Neonatology. 2022;119(6):695-702. doi: 10.1159/000525709. Epub 2022 Nov 3. Neonatology. 2022. PMID: 36327925
INTRODUCTION: Sepsis is regarded as a risk factor for brain injury in preterm infants. We herein hypothesize that extremely low birth weight infants (ELBWI, birth weight <1,000 g) having survived recurrent blood culture-proven late-onset sepsis (LOS) episodes are …
INTRODUCTION: Sepsis is regarded as a risk factor for brain injury in preterm infants. We herein hypothesize that extremely low birth …
Sleep problems in infancy and early school age in very preterm infants.
Neitmann J, Hanke K, Humberg A, Siller B, Spiegler J, Juhnke K, Gilmore J, Odendahl R, Herting E, Göpel W, Härtel C, Fortmann I; German Neonatal Network (GNN). Neitmann J, et al. Among authors: herting e. Early Hum Dev. 2022 Oct;173:105656. doi: 10.1016/j.earlhumdev.2022.105656. Epub 2022 Aug 15. Early Hum Dev. 2022. PMID: 35987047
BACKGROUND: Sleep plays an important role for psychological and physical health, especially in infants at high risk for long-term neurodevelopmental impairment such as preterm infants. OBJECTIVE: Our study aimed at determining risk factors for long-term sleep impair …
BACKGROUND: Sleep plays an important role for psychological and physical health, especially in infants at high risk for long-term neu …
Lactoferrin and Human Neutrophil Protein (HNP) 1-3 Levels During the Neonatal Period in Preterm Infants.
Faust KB, Moser K, Bartels M, Fortmann I, Hanke K, Wieg C, Stichtenoth G, Göpel W, Herting E, Härtel C. Faust KB, et al. Among authors: herting e. Front Pediatr. 2022 Jul 27;10:909176. doi: 10.3389/fped.2022.909176. eCollection 2022. Front Pediatr. 2022. PMID: 35967550 Free PMC article.
Antimicrobial polypeptides (APPs) are part of the innate immune system, but their specific role in the context of preterm birth is not yet understood. The aim of this investigation was to determine the systemic expression of APPs, i.e., lactoferrin (LF) and human neutrophi …
Antimicrobial polypeptides (APPs) are part of the innate immune system, but their specific role in the context of preterm birth is no …
Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation.
Härtel C, Herting E, Humberg A, Hanke K, Mehler K, Keller T, Mauer I, Frieauff E, Meyer S, Thome UH, Wieg C, Schmidtke S, Kribs A, Göpel W; German Neonatal Network. Härtel C, et al. Among authors: herting e. JAMA Netw Open. 2022 Aug 1;5(8):e2225810. doi: 10.1001/jamanetworkopen.2022.25810. JAMA Netw Open. 2022. PMID: 35943742 Free PMC article.
RESULTS: A total of 6542 infants (3030 [46.3%] female and 3512 [53.7%] male; mean [SD] GA, 25.3 (1.1) weeks; mean [SD] birth weight, 715 [180] g) were analyzed; 2534 infants (38.7%) received LISA, which was most frequently given quasi-prophylactically during delivery room …
RESULTS: A total of 6542 infants (3030 [46.3%] female and 3512 [53.7%] male; mean [SD] GA, 25.3 (1.1) weeks; mean [SD] birth weight, …
Hyperoxia/Hypoxia Exposure Primes a Sustained Pro-Inflammatory Profile of Preterm Infant Macrophages Upon LPS Stimulation.
Twisselmann N, Pagel J, Künstner A, Weckmann M, Hartz A, Glaser K, Hilgendorff A, Göpel W, Busch H, Herting E, Weinberg JB, Härtel C. Twisselmann N, et al. Among authors: herting e. Front Immunol. 2021 Nov 18;12:762789. doi: 10.3389/fimmu.2021.762789. eCollection 2021. Front Immunol. 2021. PMID: 34868007 Free PMC article.
Therefore, we aimed to determine age-dependent differences in immune responses of monocyte-derived M comparing cord blood samples derived from preterm (n=14) and term (n=19) infants as well as peripheral blood samples from healthy adults (n=17) after lipopolysaccharide (LP …
Therefore, we aimed to determine age-dependent differences in immune responses of monocyte-derived M comparing cord blood samples derived fr …
Association of ApoE Genotypes and Recovery From Intracerebral Hemorrhage in Very Low Birth Weight Infants.
Humberg A, Dzietko M, Schulz S, Felderhoff-Müser U, Hüning B, Stein A, Fortmann MI, Marissen J, Rausch TK, Herting E, Härtel C, Göpel W; German Neonatal Network (GNN). Humberg A, et al. Among authors: herting e. Stroke. 2022 Feb;53(2):514-522. doi: 10.1161/STROKEAHA.120.033432. Epub 2021 Oct 8. Stroke. 2022. PMID: 34619984
METHODS: In this multicenter observational cohort study, very low birth weight (<1500 g, <32 weeks gestational age) children were studied for cerebral palsy (CP) after ultrasound diagnosed ICH stratified by APOE genotype. ...CONCLUSIONS: APOE-epsilon4 carriers have a …
METHODS: In this multicenter observational cohort study, very low birth weight (<1500 g, <32 weeks gestational age) children we …
51 results