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The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome.
Leifsdottir K, Jost K, Siljehav V, Thelin EP, Lassarén P, Nilsson P, Haraldsson Á, Eksborg S, Herlenius E. Leifsdottir K, et al. Among authors: herlenius e. Front Pediatr. 2022 Jul 19;10:921444. doi: 10.3389/fped.2022.921444. eCollection 2022. Front Pediatr. 2022. PMID: 35928685 Free PMC article.
BACKGROUND: Survival rate increases for preterm infants, but long-term neurodevelopmental outcome predictors are lacking. Our primary aim was to determine whether a specific proteomic profile in cerebrospinal fluid (CSF) of preterm infants differs from that of term …
BACKGROUND: Survival rate increases for preterm infants, but long-term neurodevelopmental outcome predictors are lacking. Our primary …
Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study.
Leifsdottir K, Thelin EP, Lassarén P, Siljehav V, Nilsson P, Eksborg S, Herlenius E. Leifsdottir K, et al. Among authors: herlenius e. Acta Paediatr. 2022 May;111(5):961-970. doi: 10.1111/apa.16277. Epub 2022 Feb 17. Acta Paediatr. 2022. PMID: 35106835 Free PMC article.
Our aim was to study the association between the proteomic profile in cerebrospinal fluid (CSF) and the degree of HIE and long-term outcomes. METHODS: We prospectively enrolled 18-term born infants with HIE and 10-term born controls between 2000 and 2004 from …
Our aim was to study the association between the proteomic profile in cerebrospinal fluid (CSF) and the degree of HIE and long-term o …
Cognitive Development Trajectories in Preterm Children With Very Low Birth Weight Longitudinally Followed Until 11 Years of Age.
Stålnacke SR, Tessma M, Böhm B, Herlenius E. Stålnacke SR, et al. Among authors: herlenius e. Front Physiol. 2019 Apr 2;10:307. doi: 10.3389/fphys.2019.00307. eCollection 2019. Front Physiol. 2019. PMID: 31001126 Free PMC article.
Background: There is a high prevalence of cognitive dysfunction in very low birthweight (500-1250 g) infants (VLBW). Understanding long-term risk factors associated with cognitive development in preterm children requires longitudinal characterization. Thus, follow-up evalu …
Background: There is a high prevalence of cognitive dysfunction in very low birthweight (500-1250 g) infants (VLBW). Understanding long-t …
Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants.
Leifsdottir K, Mehmet H, Eksborg S, Herlenius E. Leifsdottir K, et al. Among authors: herlenius e. J Neuroinflammation. 2018 Aug 8;15(1):223. doi: 10.1186/s12974-018-1253-y. J Neuroinflammation. 2018. PMID: 30089504 Free PMC article.
This cohort study assessed whether Fas-ligand (FasL) and interleukin (IL)-6 levels in the cerebrospinal fluid (CSF) after hypoxic-ischemic encephalopathy (HIE) can serve as biomarkers of hypoxic brain injury in neonates. METHODS: Term infants (> 37-week gestational age) …
This cohort study assessed whether Fas-ligand (FasL) and interleukin (IL)-6 levels in the cerebrospinal fluid (CSF) after hypoxic-ischemic e …
[Hospital readmission after postpartum discharge of term newborns in two maternity wards in Stockholm and Marseille].
Boubred F, Herlenius E, Andres V, des Robert C, Marchini G. Boubred F, et al. Among authors: herlenius e. Arch Pediatr. 2016 Mar;23(3):234-40. doi: 10.1016/j.arcped.2015.12.011. Epub 2016 Feb 15. Arch Pediatr. 2016. PMID: 26899902 French.
The consequences of early postpartum discharge (EPPD, within 2 days after birth) on newborn health remain debated. Early discharge has been associated with increased neonatal morbidity. However, neonatal re-hospitalization can be prevented by careful follow-up during the 1 …
The consequences of early postpartum discharge (EPPD, within 2 days after birth) on newborn health remain debated. Early discharge ha …
Prostaglandin E2 Mediates Cardiorespiratory Disturbances during Infection in Neonates.
Siljehav V, Hofstetter AM, Leifsdottir K, Herlenius E. Siljehav V, et al. Among authors: herlenius e. J Pediatr. 2015 Dec;167(6):1207-13.e3. doi: 10.1016/j.jpeds.2015.08.053. Epub 2015 Oct 2. J Pediatr. 2015. PMID: 26434370 Free article.
STUDY DESIGN: Of 59 eligible infants, 25 preterm infants (mean gestational age, 28 0.5 weeks) and 22 full-term infants (mean gestational age, 40 0.5 weeks) from a level 3 neonatal intensive care unit and the general maternity neonatal ward were enrolled prospectively. ...I …
STUDY DESIGN: Of 59 eligible infants, 25 preterm infants (mean gestational age, 28 0.5 weeks) and 22 full-term infants (mean gestatio …
Prediction of Late Death or Disability at Age 5 Years Using a Count of 3 Neonatal Morbidities in Very Low Birth Weight Infants.
Schmidt B, Roberts RS, Davis PG, Doyle LW, Asztalos EV, Opie G, Bairam A, Solimano A, Arnon S, Sauve RS; Caffeine for Apnea of Prematurity (CAP) Trial Investigators; Caffeine for Apnea of Prematurity CAP Trial Investigators. Schmidt B, et al. J Pediatr. 2015 Nov;167(5):982-6.e2. doi: 10.1016/j.jpeds.2015.07.067. Epub 2015 Aug 28. J Pediatr. 2015. PMID: 26318030
OBJECTIVE: To evaluate bronchopulmonary dysplasia (BPD), serious brain injury, and severe retinopathy of prematurity (ROP) as predictors of poor long-term outcome in very low birth weight infants. STUDY DESIGN: We examined the associations between counts of the 3 mo …
OBJECTIVE: To evaluate bronchopulmonary dysplasia (BPD), serious brain injury, and severe retinopathy of prematurity (ROP) as predictors of …
Il-1β and prostaglandin E2 attenuate the hypercapnic as well as the hypoxic respiratory response via prostaglandin E receptor type 3 in neonatal mice.
Siljehav V, Shvarev Y, Herlenius E. Siljehav V, et al. Among authors: herlenius e. J Appl Physiol (1985). 2014 Nov 1;117(9):1027-36. doi: 10.1152/japplphysiol.00542.2014. Epub 2014 Sep 11. J Appl Physiol (1985). 2014. PMID: 25213632 Free article.
Prostaglandin E2 (PGE2) serves as a critical mediator of hypoxia, infection, and apnea in term and preterm babies. We hypothesized that the prostaglandin E receptor type 3 (EP3R) is the receptor responsible for PGE2-induced apneas. ...
Prostaglandin E2 (PGE2) serves as a critical mediator of hypoxia, infection, and apnea in term and preterm babies. We hypothesized th …
PGE-metabolite levels in CSF correlate to HIE score and outcome after perinatal asphyxia.
Björk L, Leifsdottir K, Saha S, Herlenius E. Björk L, et al. Among authors: herlenius e. Acta Paediatr. 2013 Nov;102(11):1041-7. doi: 10.1111/apa.12361. Epub 2013 Aug 19. Acta Paediatr. 2013. PMID: 23869598
We hypothesize that PGE2 is released in human cerebrospinal fluid (CSF) during perinatal asphyxia and that it might be used as a biomarker for perinatal asphyxia. METHODS: In full-term infants with lumbar puncture performed within 72 h of birth (n = 35), CSF was ana …
We hypothesize that PGE2 is released in human cerebrospinal fluid (CSF) during perinatal asphyxia and that it might be used as a biomarker f …
Impact of delivery room resuscitation on outcomes up to 18 months in very low birth weight infants.
DeMauro SB, Roberts RS, Davis P, Alvaro R, Bairam A, Schmidt B; Caffeine for Apnea of Prematurity Trial Investigators. DeMauro SB, et al. J Pediatr. 2011 Oct;159(4):546-50.e1. doi: 10.1016/j.jpeds.2011.03.025. Epub 2011 May 17. J Pediatr. 2011. PMID: 21592510 Clinical Trial.
OBJECTIVE: To examine the relationships between intensity of delivery room resuscitation and short- and long-term outcomes of very low birth weight infants enrolled in the Caffeine for Apnea of Prematurity (CAP) Trial. ...
OBJECTIVE: To examine the relationships between intensity of delivery room resuscitation and short- and long-term outcomes of very lo …
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