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Effects of chronic transfusions on abdominal sonographic abnormalities in children with sickle cell anemia.
McCarville MB, Rogers ZR, Sarnaik S, Scott P, Aygun B, Hilliard L, Lee MT, Kalinyak K, Owen W, Garro J, Schultz W, Yovetich N, Ware RE; SWiTCH Investigators. McCarville MB, et al. J Pediatr. 2012 Feb;160(2):281-285.e1. doi: 10.1016/j.jpeds.2011.07.050. Epub 2011 Sep 9. J Pediatr. 2012. PMID: 21907352 Free PMC article.
Liver (P<.001) and renal lengths (P.005) were larger than published norms. CONCLUSIONS: In children with SCA, long-term transfusion therapy may not prevent development or progression of abdominal organ dysfunction....
Liver (P<.001) and renal lengths (P.005) were larger than published norms. CONCLUSIONS: In children with SCA, long-term transfusio …
Stroke With Transfusions Changing to Hydroxyurea (SWiTCH): a phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload.
Ware RE, Schultz WH, Yovetich N, Mortier NA, Alvarez O, Hilliard L, Iyer RV, Miller ST, Rogers ZR, Scott JP, Waclawiw M, Helms RW. Ware RE, et al. Among authors: helms rw. Pediatr Blood Cancer. 2011 Dec 1;57(6):1011-7. doi: 10.1002/pbc.23145. Epub 2011 Aug 8. Pediatr Blood Cancer. 2011. PMID: 21826782 Free PMC article. Clinical Trial.
Chronic monthly erythrocyte transfusions effectively prevent recurrent stroke, but their long-term use is limited by serious side effects, including iron overload. ...
Chronic monthly erythrocyte transfusions effectively prevent recurrent stroke, but their long-term use is limited by serious side eff …
Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group.
Kinney TR, Helms RW, O'Branski EE, Ohene-Frempong K, Wang W, Daeschner C, Vichinsky E, Redding-Lallinger R, Gee B, Platt OS, Ware RE. Kinney TR, et al. Among authors: helms rw. Blood. 1999 Sep 1;94(5):1550-4. Blood. 1999. PMID: 10477679 Free article. Clinical Trial.
Previous studies have determined the short-term toxicity profile, laboratory changes, and clinical efficacy associated with hydroxyurea (HU) therapy in adults with sickle cell anemia. ...
Previous studies have determined the short-term toxicity profile, laboratory changes, and clinical efficacy associated with hydroxyur …
EM mixed model analysis of data from informatively censored normal distributions.
Smith FB, Helms RW. Smith FB, et al. Among authors: helms rw. Biometrics. 1995 Jun;51(2):425-36. Biometrics. 1995. PMID: 7662835
Maximum likelihood techniques using the EM algorithm are applied to correlated normally distributed survival data from a placebo-controlled, double-blind, dose-ranging crossover study to assess the short-term efficacy of an antianginal drug in patients with chronic stable …
Maximum likelihood techniques using the EM algorithm are applied to correlated normally distributed survival data from a placebo-controlled, …