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A longitudinal study of cannabis use and risk for cognitive and functional decline among older adults with HIV.
Watson CW, Sundermann E, Helm J, Paolillo EW, Hong S, Ellis RJ, Letendre S, Marcotte TD, Heaton RK, Morgan EE, Grant I. Watson CW, et al. Among authors: helm j. AIDS Behav. 2023 Oct;27(10):3401-3413. doi: 10.1007/s10461-023-04056-6. Epub 2023 May 8. AIDS Behav. 2023. PMID: 37155086 Free PMC article.
Recent cannabis use was linked to worse cognition at study visits when participants had THC+ urine toxicology-this short-term decrement in cognition was driven by worse memory and did not extend to reports of functional declines. ...
Recent cannabis use was linked to worse cognition at study visits when participants had THC+ urine toxicology-this short-term decreme …
Allele-specific targeting of mutant ataxin-3 by antisense oligonucleotides in SCA3-iPSC-derived neurons.
Hauser S, Helm J, Kraft M, Korneck M, Hübener-Schmid J, Schöls L. Hauser S, et al. Among authors: helm j. Mol Ther Nucleic Acids. 2021 Nov 19;27:99-108. doi: 10.1016/j.omtn.2021.11.015. eCollection 2022 Mar 8. Mol Ther Nucleic Acids. 2021. PMID: 34938609 Free PMC article.
We found ASOmut4 to reduce levels of mutant ataxin-3 by 80% after 10 days while leaving expression of wild-type ataxin-3 largely unaffected. In a long-term study we proved this effect to last for about 4 weeks after a single treatment without signs of neurotoxicity. ...
We found ASOmut4 to reduce levels of mutant ataxin-3 by 80% after 10 days while leaving expression of wild-type ataxin-3 largely unaffected. …
Low-cost chamber design for simultaneous CO2 and O2 flux measurements between tree stems and the atmosphere.
Helm J, Hartmann H, Göbel M, Hilman B, Herrera Ramírez D, Muhr J. Helm J, et al. Tree Physiol. 2021 Sep 10;41(9):1767-1780. doi: 10.1093/treephys/tpab022. Tree Physiol. 2021. PMID: 33677590 Free PMC article.
Here, we present a new and low-cost field-tested device for autonomous real-time and quasi-continuous long-term measurements of stem respiration by combining CO2 (NDIR-based) and O2 (quenching-based) sensors in a tree stem chamber. ...
Here, we present a new and low-cost field-tested device for autonomous real-time and quasi-continuous long-term measurements of stem …
Retro-rectus placement of bio-absorbable mesh improves patient outcomes.
Cho JE, Helm MC, Helm JH, Mier N, Kastenmeier AS, Gould JC, Goldblatt MI. Cho JE, et al. Among authors: helm jh. Surg Endosc. 2019 Aug;33(8):2629-2634. doi: 10.1007/s00464-018-6560-y. Epub 2018 Oct 25. Surg Endosc. 2019. PMID: 30361969
Both the retro-rectus and intraperitoneal groups indicated a significant (p < 0.05) improvement in quality of life from baseline. No long-term (> 7 days) antibiotics were used and no mesh implants were removed during the study. ...

Both the retro-rectus and intraperitoneal groups indicated a significant (p < 0.05) improvement in quality of life from baseline. No long

…
Linking autonomic physiology and emotion regulation in preschoolers: The role of reactivity and recovery.
Kahle S, Miller JG, Helm JL, Hastings PD. Kahle S, et al. Among authors: helm jl. Dev Psychobiol. 2018 Nov;60(7):775-788. doi: 10.1002/dev.21746. Epub 2018 Jun 21. Dev Psychobiol. 2018. PMID: 29926898
Disengaging from an emotional challenge may be linked with reduced physiological arousal in the short term, this behavior but also appears to have delayed consequences for physiological recovery....
Disengaging from an emotional challenge may be linked with reduced physiological arousal in the short term, this behavior but also ap …
Predictors of CD4 cell recovery following initiation of antiretroviral therapy among HIV-1 positive patients with well-estimated dates of seroconversion.
Stirrup OT, Copas AJ, Phillips AN, Gill MJ, Geskus RB, Touloumi G, Young J, Bucher HC, Babiker AG; CASCADE Collaboration in EuroCoord. Stirrup OT, et al. HIV Med. 2018 Mar;19(3):184-194. doi: 10.1111/hiv.12567. Epub 2017 Dec 1. HIV Med. 2018. PMID: 29230953 Free PMC article.
OBJECTIVES: To investigate factors that predict speed of recovery and long-term CD4 cell count in HIV-1 seroconverters initiating combination antiretroviral therapy (cART), and to quantify the influence of very early treatment initiation. ...
OBJECTIVES: To investigate factors that predict speed of recovery and long-term CD4 cell count in HIV-1 seroconverters initiating com …
Modeling Self-Regulation as a Process Using a Multiple Time-Scale Multiphase Latent Basis Growth Model.
Helm JL, Ram N, Cole PM, Chow SM. Helm JL, et al. Struct Equ Modeling. 2016;23(5):635-648. doi: 10.1080/10705511.2016.1178580. Epub 2016 May 19. Struct Equ Modeling. 2016. PMID: 28255223 Free PMC article.
This paper develops a model that may be useful in situations where the functional form of short-term change is unknown, may consist of multiple phases, and may change over the long-term. ...Empirical data from a longitudinal study of young children's behavior during …
This paper develops a model that may be useful in situations where the functional form of short-term change is unknown, may consist o …
Characterisation of long-term non-progression of HIV-1 infection after seroconversion: a cohort study.
van der Helm JJ, Geskus R, Lodi S, Meyer L, Schuitemaker H, Gunsenheimer-Bartmeyer B, Monforte Ad, Olson A, Touloumi G, Sabin C, Porter K, Prins M; CASCADE Collaboration in EuroCoord. van der Helm JJ, et al. Lancet HIV. 2014 Oct;1(1):e41-8. doi: 10.1016/S2352-3018(14)70016-5. Epub 2014 Sep 18. Lancet HIV. 2014. PMID: 26423816
BACKGROUND: Some individuals remain AIDS-free with a high and stable CD4 cell count without antiretroviral therapy (ART) for many years. We estimated long-term progression-free survival after HIV seroconversion and aimed to identify factors associated with loss of long- …
BACKGROUND: Some individuals remain AIDS-free with a high and stable CD4 cell count without antiretroviral therapy (ART) for many years. We …
17 results