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CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants.
Baruah A, Chang H, Hall M, Yuan J, Gordon S, Johnson E, Shtessel LL, Yee C, Hekimi S, Derry WB, Lee SS. Baruah A, et al. Among authors: hekimi s. PLoS Genet. 2014 Feb 27;10(2):e1004097. doi: 10.1371/journal.pgen.1004097. eCollection 2014 Feb. PLoS Genet. 2014. PMID: 24586177 Free PMC article.
Interestingly, this small group of differentially regulated genes are enriched for the "aging" Gene Ontology term, consistent with the hypothesis that they might be particularly important for mediating the distinct longevity effects of CEP-1 in isp-1 and mev-1 mutants. ...
Interestingly, this small group of differentially regulated genes are enriched for the "aging" Gene Ontology term, consistent with th …
An enhanced immune response of Mclk1⁺/⁻ mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging.
Wang D, Wang Y, Argyriou C, Carrière A, Malo D, Hekimi S. Wang D, et al. Among authors: hekimi s. PLoS One. 2012;7(11):e49606. doi: 10.1371/journal.pone.0049606. Epub 2012 Nov 14. PLoS One. 2012. PMID: 23166727 Free PMC article.
However, inflammation, one aspect of this response, can result in short- and long-term deleterious side-effects. Mclk1+/- mutant mice can be long-lived despite displaying a hair-trigger inflammatory response and chronically activated macrophages as a result of high mitocho …
However, inflammation, one aspect of this response, can result in short- and long-term deleterious side-effects. Mclk1+/- mutant mice …
Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice.
Lapointe J, Stepanyan Z, Bigras E, Hekimi S. Lapointe J, et al. Among authors: hekimi s. J Biol Chem. 2009 Jul 24;284(30):20364-74. doi: 10.1074/jbc.M109.006569. Epub 2009 May 28. J Biol Chem. 2009. PMID: 19478076 Free PMC article.
Thus, our study provides for a unique vertebrate model in which an initial alteration in a specific mitochondrial function is linked to long term beneficial effects on biomarkers of aging and, furthermore, provides for new evidence which indicates that mitochondrial oxidat …
Thus, our study provides for a unique vertebrate model in which an initial alteration in a specific mitochondrial function is linked to long …