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Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling.
Iyer-Bierhoff A, Wieczorek M, Peter SM, Ward D, Bens M, Vettorazzi S, Guehrs KH, Tuckermann JP, Heinzel T. Iyer-Bierhoff A, et al. Among authors: heinzel t. iScience. 2024 Jan 18;27(2):108943. doi: 10.1016/j.isci.2024.108943. eCollection 2024 Feb 16. iScience. 2024. PMID: 38333702 Free PMC article.
Notably, agonist-binding to both wild-type GR and an acetylation-deficient mutant elicits similar short-term target gene expression. In contrast, upon extended treatment, the polyubiquitination of the acetylation-deficient GR mutant is impaired resulting in higher protein …
Notably, agonist-binding to both wild-type GR and an acetylation-deficient mutant elicits similar short-term target gene expression. …
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress.
Marx C, Sonnemann J, Maddocks ODK, Marx-Blümel L, Beyer M, Hoelzer D, Thierbach R, Maletzki C, Linnebacher M, Heinzel T, Krämer OH. Marx C, et al. Among authors: heinzel t. Cancer Metab. 2022 Jul 4;10(1):10. doi: 10.1186/s40170-022-00286-9. Cancer Metab. 2022. PMID: 35787728 Free PMC article.
METHODS: We incubated p53-positive and p53-negative permanent CRC cells and short-term cultured primary CRC cells with the topoisomerase-1 inhibitor irinotecan and other drugs that cause DNA replication stress and consequently DNA damage. ...
METHODS: We incubated p53-positive and p53-negative permanent CRC cells and short-term cultured primary CRC cells with the topoisomer …
Negative glucocorticoid receptor response elements and their role in glucocorticoid action.
Dostert A, Heinzel T. Dostert A, et al. Among authors: heinzel t. Curr Pharm Des. 2004;10(23):2807-16. doi: 10.2174/1381612043383601. Curr Pharm Des. 2004. PMID: 15379669 Review.
Due to their broad therapeutic spectrum and superior therapeutic effects glucocorticoids (GCs) are the most effective drugs used for the treatment of acute and chronic inflammatory diseases. Unfortunately, long term systemic therapy with GCs is restricted due to their meta …
Due to their broad therapeutic spectrum and superior therapeutic effects glucocorticoids (GCs) are the most effective drugs used for the tre …