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Effects of an Amino Acid-Based Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety, and Gut Microbiome in Infants with Cow's Milk Protein Allergy.
Gold MS, Quinn PJ, Campbell DE, Peake J, Smart J, Robinson M, O'Sullivan M, Vogt JK, Pedersen HK, Liu X, Pazirandeh-Micol E, Heine RG. Gold MS, et al. Among authors: heine rg. Nutrients. 2022 May 30;14(11):2297. doi: 10.3390/nu14112297. Nutrients. 2022. PMID: 35684099 Free PMC article.
This open-label, non-randomized, multicenter trial (Registration: NCT03661736) aimed to assess if an amino acid-based formula (AAF) supplemented with two human milk oligosaccharides (HMO) supports normal growth and is well tolerated in infants with a cow's milk protein allergy (C …
This open-label, non-randomized, multicenter trial (Registration: NCT03661736) aimed to assess if an amino acid-based formula (AAF) suppleme …
Growth in Infants with Cow's Milk Protein Allergy Fed an Amino Acid-Based Formula.
Vandenplas Y, Dupont C, Eigenmann P, Heine RG, Høst A, Järvi A, Kuitunen M, Mukherjee R, Ribes-Koninckx C, Szajewska H, von Berg A, Zhao ZY; Mosaic Study Investigator Group. Vandenplas Y, et al. Among authors: heine rg. Pediatr Gastroenterol Hepatol Nutr. 2021 Jul;24(4):392-402. doi: 10.5223/pghn.2021.24.4.392. Epub 2021 Jul 5. Pediatr Gastroenterol Hepatol Nutr. 2021. PMID: 34316474 Free PMC article.
PURPOSE: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy (CMPA). METHODS: Non-breastfed, term infants aged 0-6 months with symptoms suggestive of CMPA were recruited from 10 pediatric centers …
PURPOSE: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy ( …
Pediatric Collagenous Gastritis and Colitis: A Case Series and Review of the Literature.
Matta J, Alex G, Cameron DJS, Chow CW, Hardikar W, Heine RG. Matta J, et al. Among authors: heine rg. J Pediatr Gastroenterol Nutr. 2018 Sep;67(3):328-334. doi: 10.1097/MPG.0000000000001975. J Pediatr Gastroenterol Nutr. 2018. PMID: 29601434 Review.
A small proportion of children develop features of the "'adult" phenotype at a very young age. Patients with collagenous gastritis require long-term follow-up and monitoring of their disease. Further randomized clinical trials are needed to establish an effective therapeut …
A small proportion of children develop features of the "'adult" phenotype at a very young age. Patients with collagenous gastritis require l …
Lactose intolerance and gastrointestinal cow's milk allergy in infants and children - common misconceptions revisited.
Heine RG, AlRefaee F, Bachina P, De Leon JC, Geng L, Gong S, Madrazo JA, Ngamphaiboon J, Ong C, Rogacion JM. Heine RG, et al. World Allergy Organ J. 2017 Dec 12;10(1):41. doi: 10.1186/s40413-017-0173-0. eCollection 2017. World Allergy Organ J. 2017. PMID: 29270244 Free PMC article. Review.
Lactose requires enzymatic hydrolysis by lactase into D-glucose and D-galactose before it can be absorbed. Term infants express sufficient lactase to digest about one liter of breast milk daily. ...
Lactose requires enzymatic hydrolysis by lactase into D-glucose and D-galactose before it can be absorbed. Term infants express suffi …
Eosinophilic oesophagitis.
Heine RG, Allen KJ. Heine RG, et al. Chem Immunol Allergy. 2015;101:199-208. doi: 10.1159/000371703. Epub 2015 May 21. Chem Immunol Allergy. 2015. PMID: 26022880
Therefore, EoE needs to be distinguished from so-called PPI-responsive oesophageal eosinophilia. The long-term prognosis of EoE remains poorly defined, and complications mainly relate to subepithelial remodelling and fibrosis that may result in dysmotility, dysphagia and o …
Therefore, EoE needs to be distinguished from so-called PPI-responsive oesophageal eosinophilia. The long-term prognosis of EoE remai …
Clinical Use of Probiotics in Pediatric Allergy (CUPPA): A World Allergy Organization Position Paper.
Fiocchi A, Burks W, Bahna SL, Bielory L, Boyle RJ, Cocco R, Dreborg S, Goodman R, Kuitunen M, Haahtela T, Heine RG, Lack G, Osborn DA, Sampson H, Tannock GW, Lee BW; WAO Special Committee on Food Allergy and Nutrition. Fiocchi A, et al. Among authors: heine rg. World Allergy Organ J. 2012 Nov;5(11):148-67. doi: 10.1097/WOX.0b013e3182784ee0. World Allergy Organ J. 2012. PMID: 23282383 Free PMC article.
Meanwhile, clinicians must take a step back and try to link disease state with alterations of the microbiota through well-controlled long-term studies to identify clinical indications. CONCLUSIONS: : Probiotics do not have an established role in the prevention or treatment …
Meanwhile, clinicians must take a step back and try to link disease state with alterations of the microbiota through well-controlled long- …
Emerging management concepts for eosinophilic esophagitis in children.
Heine RG, Nethercote M, Rosenbaum J, Allen KJ. Heine RG, et al. J Gastroenterol Hepatol. 2011 Jul;26(7):1106-13. doi: 10.1111/j.1440-1746.2011.06757.x. J Gastroenterol Hepatol. 2011. PMID: 21545525 Review.
There is a paucity of data on both the natural history and optimal long-term management of EoE. Current treatment options include food allergen elimination diets, use of topical aerosolized corticosteroids, or a combination of the two. ...
There is a paucity of data on both the natural history and optimal long-term management of EoE. Current treatment options include foo …
Eosinophilic esophagitis: trials and tribulations.
Allen KJ, Heine RG. Allen KJ, et al. Among authors: heine rg. J Clin Gastroenterol. 2011 Aug;45(7):574-82. doi: 10.1097/MCG.0b013e31820656dd. J Clin Gastroenterol. 2011. PMID: 21415771 Review.
This article aims to discuss the complex issues of the diagnosis and long-term management that confront clinicians who care for children with EE....
This article aims to discuss the complex issues of the diagnosis and long-term management that confront clinicians who care for child …
Eosinophilic esophagitis: example of an emerging allergic manifestation?
Heine RG. Heine RG. Nestle Nutr Workshop Ser Pediatr Program. 2009;64:105-15; discussion 116-20, 251-7. doi: 10.1159/000235786. Epub 2009 Aug 19. Nestle Nutr Workshop Ser Pediatr Program. 2009. PMID: 19710518 Review.
While dysphagia, regurgitation and retrosternal pain are the clinical hallmarks of EE, many patients are asymptomatic. Treatment aims to prevent long-term complications, such as acute food bolus impaction or esophageal strictures. ...Further prospective clinical trials are …
While dysphagia, regurgitation and retrosternal pain are the clinical hallmarks of EE, many patients are asymptomatic. Treatment aims to pre …
Egg allergy in childhood: an update.
Tey D, Heine RG. Tey D, et al. Among authors: heine rg. Curr Opin Allergy Clin Immunol. 2009 Jun;9(3):244-50. doi: 10.1097/ACI.0b013e32832b1f00. Curr Opin Allergy Clin Immunol. 2009. PMID: 19369862 Review.
In recent years, there has been increasing success in clinical trials of specific oral tolerance induction to egg, but concerns regarding the safety and long-term efficacy still preclude the use of oral immunotherapy in clinical practice. ...
In recent years, there has been increasing success in clinical trials of specific oral tolerance induction to egg, but concerns regarding th …
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