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Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care - The PreFace Study.
Hack CC, Maass N, Aktas B, Kümmel S, Thomssen C, Wolf C, Kolberg HC, Brucker C, Janni W, Dall P, Schneeweiss A, Marme F, Ruebner M, Theuser AK, Hofmann NM, Böhm S, Almstedt K, Kellner S, Gass P, Sütterlin MW, Lück HJ, Schmatloch S, Kalder M, Uleer C, Juhasz-Böss I, Hanf V, Jackisch C, Müller V, Rack B, Belleville E, Wallwiener D, Rody A, Rauh C, Bayer CM, Uhrig S, Goossens C, Huebner H, Brucker SY, Häberle L, Fehm TN, Hein A, Fasching PA. Hack CC, et al. Among authors: hein a. Geburtshilfe Frauenheilkd. 2024 Feb 8;84(2):185-195. doi: 10.1055/a-2238-3153. eCollection 2024 Feb. Geburtshilfe Frauenheilkd. 2024. PMID: 38344045 Free PMC article.
Concurrent RB1 loss and BRCA-deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma.
Saner FAM, Takahashi K, Budden T, Pandey A, Ariyaratne D, Zwimpfer TA, Meagher NS, Fereday S, Twomey L, Pishas KI, Hoang T, Bolithon A, Traficante N, Alsop K, Christie EL, Kang EY, Nelson GS, Ghatage P, Lee CH, Riggan MJ, Alsop J, Beckmann MW, Boros J, Brand AH, Brooks-Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, El-Bahrawy MA, Elishaev E, Erber R, Gayther SA, Gentry-Maharaj A, Blake Gilks C, Harnett PR, Harris HR, Hartmann A, Hein A, Hendley J; AOCS Group; Hernandez BY, Jakubowska A, Jimenez-Linan M, Jones ME, Kaufmann SH, Kennedy CJ, Kluz T, Koziak JM, Kristjansdottir B, Le ND, Lener M, Lester J, Lubiński J, Mateoiu C, Orsulic S, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Singh N, Rinda Soong T, Steed H, Sukumvanich P, Talhouk A, Taylor SE, Vierkant RA, Wang C, Widschwendter M, Wilkens LR, Winham SJ, Anglesio MS, Berchuck A, Brenton JD, Campbell I, Cook LS, Doherty JA, Fasching PA, Fortner RT, Goodman MT, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Menon U, Modugno F, Pharoah PDP, Schildkraut JM, Sundfeldt K, Swerdlow AJ, Goode EL, DeFazio A, Köbel M, Ramus SJ, Bowtell DDL, Garsed DW. Saner FAM, et al. Among authors: hein a. medRxiv [Preprint]. 2023 Nov 10:2023.11.09.23298321. doi: 10.1101/2023.11.09.23298321. medRxiv. 2023. PMID: 37986741 Free PMC article. Preprint.
We examined whether tumour expression of RB1 was associated with survival across ovarian cancer histotypes (HGSC, endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous carcinoma (LGSC)), and how co-occurrence of germline BRCA pathogenic variants and RB1 loss in …
We examined whether tumour expression of RB1 was associated with survival across ovarian cancer histotypes (HGSC, endometrioid (ENOC), clear …
Comparison of machine learning approaches for near-fall-detection with motion sensors.
Hellmers S, Krey E, Gashi A, Koschate J, Schmidt L, Stuckenschneider T, Hein A, Zieschang T. Hellmers S, et al. Among authors: hein a. Front Digit Health. 2023 Jul 26;5:1223845. doi: 10.3389/fdgth.2023.1223845. eCollection 2023. Front Digit Health. 2023. PMID: 37564882 Free PMC article.
We investigated different machine learning models for the near-fall detection including support vector machines, AdaBoost, convolutional neural networks, and bidirectional long short-term memory networks. Additionally, we analyzed the influence of the sensor position on th …
We investigated different machine learning models for the near-fall detection including support vector machines, AdaBoost, convolutional neu …
Pembrolizumab in combination with nab-paclitaxel for the treatment of patients with early-stage triple-negative breast cancer - A single-arm phase II trial (NeoImmunoboost, AGO-B-041).
Fasching PA, Hein A, Kolberg HC, Häberle L, Uhrig S, Rübner M, Belleville E, Hack CC, Fehm TN, Janni W, Hartmann A, Erber R, Theuser AK, Brucker SY, Hartkopf AD, Untch M. Fasching PA, et al. Among authors: hein a. Eur J Cancer. 2023 May;184:1-9. doi: 10.1016/j.ejca.2023.01.001. Epub 2023 Jan 9. Eur J Cancer. 2023. PMID: 36871424 Free article. Clinical Trial.
With acceptable side-effect profiles, this treatment might be a reasonable alternative to platinum-containing chemotherapy in cases of contraindications. However, without data from randomised trials and long-term follow up, platinum/anthracycline/taxane-based chemotherapy …
With acceptable side-effect profiles, this treatment might be a reasonable alternative to platinum-containing chemotherapy in cases of contr …
Lack of evidence for effects of lockdowns on stillbirth rates during the SARS-CoV-2 pandemic in Bavaria: analysis of the Bavarian perinatal survey from 2010 to 2020.
Stumpfe FM, Schneider MO, Antoniadis S, Mayr A, Fleckenstein T, Staerk C, Kehl S, Hermanek P, Böhm J, Scharl A, Beckmann MW, Hein A. Stumpfe FM, et al. Among authors: hein a. Arch Gynecol Obstet. 2023 Nov;308(5):1457-1462. doi: 10.1007/s00404-022-06838-0. Epub 2022 Nov 9. Arch Gynecol Obstet. 2023. PMID: 36348075 Free PMC article.
RESULTS: During the first lockdown, the stillbirth rate was significantly higher compared to the reference period (4.04 vs. 3.03 stillbirths per 1000 births; P = 0.03). After adjustment for seasonal and long-term trends, this effect can no longer be observed (P = 0.2). Dur …
RESULTS: During the first lockdown, the stillbirth rate was significantly higher compared to the reference period (4.04 vs. 3.03 stillbirths …
Are vertical jumps able to predict 24-month follow-up functional geriatric assessment in a healthy community-dwelling older cohort?
Diekmann R, Hellmers S, Lau S, Heinks A, Elgert L, Bauer JM, Zieschang T, Hein A. Diekmann R, et al. Among authors: hein a. Aging Clin Exp Res. 2022 Nov;34(11):2769-2778. doi: 10.1007/s40520-022-02230-9. Epub 2022 Sep 2. Aging Clin Exp Res. 2022. PMID: 36053442 Free PMC article.
CONCLUSION: The potential of jumping power to predict single tests of FGA was low regarding sensitivity and specificity of CMC (or MDC). 6 months deltamax JP seem to be suitable for predicting physical function, if the measured and predicted tests were not compared at the test le …
CONCLUSION: The potential of jumping power to predict single tests of FGA was low regarding sensitivity and specificity of CMC (or MDC). 6 m …
Limited Effects of SARS-CoV-2 Pandemic-related Lockdowns and Reduced Population Mobility on Preterm Birth Rates: A Secondary Analysis of Bavarian Obstetric Quality Parameters from 2010 to 2020.
Stumpfe FM, Schneider MO, Hein A, Faschingbauer F, Kehl S, Hermanek P, Böhm J, Scharl A, Beckmann MW, Staerk C, Mayr A. Stumpfe FM, et al. Among authors: hein a. Geburtshilfe Frauenheilkd. 2022 Jul 15;82(8):842-851. doi: 10.1055/a-1857-6414. eCollection 2022 Aug. Geburtshilfe Frauenheilkd. 2022. PMID: 35967741 Free PMC article.
Potential effects of two fixed lockdown periods and of variable changes in population mobility on preterm birth rates in 2020 were examined using additive logistic regression models, adjusting for long-term and seasonal trends. ...However, these effects are reduced …
Potential effects of two fixed lockdown periods and of variable changes in population mobility on preterm birth rates in 2020 were ex …
Sentinel fall presenting to the emergency department (SeFallED) - protocol of a complex study including long-term observation of functional trajectories after a fall, exploration of specific fall risk factors, and patients' views on falls prevention.
Stuckenschneider T, Koschate J, Dunker E, Reeck N, Hackbarth M, Hellmers S, Kwiecien R, Lau S, Levke Brütt A, Hein A, Zieschang T. Stuckenschneider T, et al. Among authors: hein a. BMC Geriatr. 2022 Jul 18;22(1):594. doi: 10.1186/s12877-022-03261-7. BMC Geriatr. 2022. PMID: 35850739 Free PMC article.
Iterative Development and Applicability of a Tablet-Based e-Coach for Older Adults in Rehabilitation Units to Improve Nutrition and Physical Activity: Usability Study.
Happe L, Sgraja M, Hein A, Diekmann R. Happe L, et al. Among authors: hein a. JMIR Hum Factors. 2022 Mar 16;9(1):e31823. doi: 10.2196/31823. JMIR Hum Factors. 2022. PMID: 35293874 Free PMC article.
Thus, good usability (SUS: 80th-84th percentile) was achieved using iterative optimizations within the user-centered design. Long-term usability and any possible effects on nutritional and physical activity behavior need to be evaluated in an additional study in which pati …
Thus, good usability (SUS: 80th-84th percentile) was achieved using iterative optimizations within the user-centered design. Long-term …
What do geriatric rehabilitation patients and experts consider relevant? Requirements for a digitalised e-coach for sustainable improvement of nutrition and physical activity in older adults - a qualitative focus group study.
Happe L, Hein A, Diekmann R. Happe L, et al. Among authors: hein a. BMC Geriatr. 2021 Dec 18;21(1):712. doi: 10.1186/s12877-021-02692-y. BMC Geriatr. 2021. PMID: 34922492 Free PMC article.
In order to maintain these improvements in the medium- and long-term, behavioural changes regarding mobility and nutrition are also targeted, but these are often not sustainable. ...
In order to maintain these improvements in the medium- and long-term, behavioural changes regarding mobility and nutrition are also t …
43 results