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Long-term effects of selective fetal growth restriction (LEMON): a cohort study of neurodevelopmental outcome in growth discordant identical twins in the Netherlands.
Groene SG, Stegmeijer KJJ, Tan RNGB, Steggerda SJ, Haak MC, Slaghekke F, Roest AAW, Heijmans BT, Lopriore E, van Klink JMM. Groene SG, et al. Among authors: heijmans bt. Lancet Child Adolesc Health. 2022 Sep;6(9):624-632. doi: 10.1016/S2352-4642(22)00159-6. Epub 2022 Jul 22. Lancet Child Adolesc Health. 2022. PMID: 35871831
FINDINGS: Between Jan 25, 2021, and March 15, 2022, 47 twin pairs were enrolled in the study and underwent neurodevelopmental assessment. The median gestational age at birth was 33.9 weeks (IQR 31.3-36.0) for the 47 included twin pairs, with median birthweights of 1400 g ( …
FINDINGS: Between Jan 25, 2021, and March 15, 2022, 47 twin pairs were enrolled in the study and underwent neurodevelopmental assessment. Th …
TwinLIFE: The Twin Longitudinal Investigation of FEtal Discordance.
Groene SG, Todtenhaupt P, van Zwet EW, van Pel M, Berkhout RJM, Haak MC, Roest AAW, Lopriore E, van Klink JMM, Heijmans BT. Groene SG, et al. Among authors: heijmans bt. Twin Res Hum Genet. 2019 Dec;22(6):617-622. doi: 10.1017/thg.2019.38. Epub 2019 Jul 25. Twin Res Hum Genet. 2019. PMID: 31342890
In TwinLIFE, we will chart intrapair differences in DNA methylation focusing on mesenchymal stromal cells isolated from cord as an advanced proxy of epigenetic dysregulation relevant for long-term health consequences. Next, we will follow up the MC twins for growth, cardio …
In TwinLIFE, we will chart intrapair differences in DNA methylation focusing on mesenchymal stromal cells isolated from cord as an advanced …
Selective Survival of Embryos Can Explain DNA Methylation Signatures of Adverse Prenatal Environments.
Tobi EW, van den Heuvel J, Zwaan BJ, Lumey LH, Heijmans BT, Uller T. Tobi EW, et al. Among authors: heijmans bt. Cell Rep. 2018 Dec 4;25(10):2660-2667.e4. doi: 10.1016/j.celrep.2018.11.023. Cell Rep. 2018. PMID: 30517855 Free article.
An adverse intrauterine environment is associated with long-term physiological changes in offspring. These are believed to be mediated by epigenomic marks, including DNA methylation (DNAm). ...
An adverse intrauterine environment is associated with long-term physiological changes in offspring. These are believed to be mediate …
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.
Tobi EW, Slieker RC, Luijk R, Dekkers KF, Stein AD, Xu KM; Biobank-based Integrative Omics Studies Consortium; Slagboom PE, van Zwet EW, Lumey LH, Heijmans BT. Tobi EW, et al. Among authors: heijmans bt. Sci Adv. 2018 Jan 31;4(1):eaao4364. doi: 10.1126/sciadv.aao4364. eCollection 2018 Jan. Sci Adv. 2018. PMID: 29399631 Free PMC article.
Our data are consistent with the hypothesis that epigenetic mechanisms mediate the influence of transient adverse environmental factors in early life on long-term metabolic health. The specific mechanism awaits elucidation....
Our data are consistent with the hypothesis that epigenetic mechanisms mediate the influence of transient adverse environmental factors in e …
Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice.
Zwamborn RA, Slieker RC, Mulder PC, Zoetemelk I, Verschuren L, Suchiman HE, Toet KH, Droog S, Slagboom PE, Kooistra T, Kleemann R, Heijmans BT. Zwamborn RA, et al. Among authors: heijmans bt. Sci Rep. 2017 Mar 3;7:43261. doi: 10.1038/srep43261. Sci Rep. 2017. PMID: 28256596 Free PMC article.
High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD has been reported to induce DNA methylation changes in white adipose tissue (WAT) near me …
High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be …
Blood lipids influence DNA methylation in circulating cells.
Dekkers KF, van Iterson M, Slieker RC, Moed MH, Bonder MJ, van Galen M, Mei H, Zhernakova DV, van den Berg LH, Deelen J, van Dongen J, van Heemst D, Hofman A, Hottenga JJ, van der Kallen CJ, Schalkwijk CG, Stehouwer CD, Tigchelaar EF, Uitterlinden AG, Willemsen G, Zhernakova A, Franke L, 't Hoen PA, Jansen R, van Meurs J, Boomsma DI, van Duijn CM, van Greevenbroek MM, Veldink JH, Wijmenga C; BIOS Consortium; van Zwet EW, Slagboom PE, Jukema JW, Heijmans BT. Dekkers KF, et al. Among authors: heijmans bt. Genome Biol. 2016 Jun 27;17(1):138. doi: 10.1186/s13059-016-1000-6. Genome Biol. 2016. PMID: 27350042 Free PMC article.
BACKGROUND: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the d …
BACKGROUND: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exp …
Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells.
Bomer N, den Hollander W, Suchiman H, Houtman E, Slieker RC, Heijmans BT, Slagboom PE, Nelissen RG, Ramos YF, Meulenbelt I. Bomer N, et al. Among authors: heijmans bt. Osteoarthritis Cartilage. 2016 Aug;24(8):1423-30. doi: 10.1016/j.joca.2016.03.009. Epub 2016 Mar 17. Osteoarthritis Cartilage. 2016. PMID: 26995110 Free article.
Although hBMSCs are widely used for cartilage engineering purposes the effects of these vast differences on cartilage regeneration and long term consequences of implantation, are not known. The use of hBMSCs or hPACs for future cartilage tissue regeneration purposes should …
Although hBMSCs are widely used for cartilage engineering purposes the effects of these vast differences on cartilage regeneration and long …
Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells.
Duggal G, Warrier S, Ghimire S, Broekaert D, Van der Jeught M, Lierman S, Deroo T, Peelman L, Van Soom A, Cornelissen R, Menten B, Mestdagh P, Vandesompele J, Roost M, Slieker RC, Heijmans BT, Deforce D, De Sutter P, De Sousa Lopes SC, Heindryckx B. Duggal G, et al. Among authors: heijmans bt. Stem Cells. 2015 Sep;33(9):2686-98. doi: 10.1002/stem.2071. Epub 2015 Jun 24. Stem Cells. 2015. PMID: 26108678
We report here a novel combination of small molecules and growth factors in culture medium (2i/LIF/basic fibroblast growth factor + Ascorbic Acid + Forskolin) facilitating rapid induction of transgene-free naive pluripotency in hESCs, as well as in mESCs, which has not been shown …
We report here a novel combination of small molecules and growth factors in culture medium (2i/LIF/basic fibroblast growth factor + Ascorbic …
Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins.
van Dongen J, Willemsen G, Heijmans BT, Neuteboom J, Kluft C, Jansen R, Penninx BW, Slagboom PE, de Geus EJ, Boomsma DI. van Dongen J, et al. Among authors: heijmans bt. Int J Obes (Lond). 2015 Jun;39(6):899-909. doi: 10.1038/ijo.2015.24. Epub 2015 Mar 13. Int J Obes (Lond). 2015. PMID: 25765203 Free PMC article.
Of the 699 MZ pairs with BMI data from 3 to 5 time points, 17 pairs (2.4%) were long-term discordant (at all available time points; mean follow-up range=6.4 years). ...CONCLUSIONS: BMI discordance is uncommon in adolescent identical pairs but increases with higher pair-mea …
Of the 699 MZ pairs with BMI data from 3 to 5 time points, 17 pairs (2.4%) were long-term discordant (at all available time points; m …
DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age.
Tobi EW, Heijmans BT, Kremer D, Putter H, Delemarre-van de Waal HA, Finken MJ, Wit JM, Slagboom PE. Tobi EW, et al. Among authors: heijmans bt. Epigenetics. 2011 Feb;6(2):171-6. doi: 10.4161/epi.6.2.13516. Epub 2011 Feb 1. Epigenetics. 2011. PMID: 20930547 Free PMC article.
We compared 38 individuals born preterm (< 32 weeks) and with a birth weight too low for their gestational age (-1SDS) and a normal postnatal growth (>-1SDS at 3 months post term; AGA). The SGA individuals were not only lighter at birth, but also had a …
We compared 38 individuals born preterm (< 32 weeks) and with a birth weight too low for their gestational age (-1SDS) and a norma …