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IgA antibody immunotherapy targeting GD2 is effective in preclinical neuroblastoma models.
Stip MC, Evers M, Nederend M, Chan C, Reiding KR, Damen MJ, Heck AJR, Koustoulidou S, Ramakers R, Krijger GC, de Roos R, Souteyrand E, Cornel AM, Dierselhuis MP, Jansen M, de Boer M, Valerius T, van Tetering G, Leusen JHW, Meyer-Wentrup F. Stip MC, et al. Among authors: heck ajr. J Immunother Cancer. 2023 Jul;11(7):e006948. doi: 10.1136/jitc-2023-006948. J Immunother Cancer. 2023. PMID: 37479484 Free PMC article.
Furthermore, IgA3.0 ch14.18 penetrates neuroblastoma tumors in vivo and halts tumor outgrowth in both 9464D-GD2 and IMR32 long-term tumor models. CONCLUSIONS: IgA3.0 ch14.18 is a promising new therapy for neuroblastoma, showing (1) increased half-life compared to natural I …
Furthermore, IgA3.0 ch14.18 penetrates neuroblastoma tumors in vivo and halts tumor outgrowth in both 9464D-GD2 and IMR32 long-term t …
Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy.
Subramaniam G, Schleicher K, Kovanich D, Zerio A, Folkmanaite M, Chao YC, Surdo NC, Koschinski A, Hu J, Scholten A, Heck AJR, Ercu M, Sholokh A, Park KC, Klussmann E, Meraviglia V, Bellin M, Zanivan S, Hester S, Mohammed S, Zaccolo M. Subramaniam G, et al. Among authors: heck ajr. Circ Res. 2023 Mar 31;132(7):828-848. doi: 10.1161/CIRCRESAHA.122.321448. Epub 2023 Mar 8. Circ Res. 2023. PMID: 36883446 Free PMC article.
Our findings reveal a mechanism that explains the negative long-term clinical outcome observed in patients with heart failure treated with PDE3 inhibitors....
Our findings reveal a mechanism that explains the negative long-term clinical outcome observed in patients with heart failure treated …
Meta-heterogeneity: Evaluating and Describing the Diversity in Glycosylation Between Sites on the Same Glycoprotein.
Čaval T, Heck AJR, Reiding KR. Čaval T, et al. Among authors: heck ajr. Mol Cell Proteomics. 2021;20:100010. doi: 10.1074/mcp.R120.002093. Epub 2020 Dec 8. Mol Cell Proteomics. 2021. PMID: 33561609 Free PMC article. Review.
It has become apparent that just describing protein glycosylation in terms of micro- and macro-heterogeneity, respectively, the variation and occupancy of glycans at a given site, is not sufficient to describe the observed interactions between sites. In this perspective we propos …
It has become apparent that just describing protein glycosylation in terms of micro- and macro-heterogeneity, respectively, the variation an …
Fishing for newly synthesized proteins with phosphonate-handles.
Kleinpenning F, Steigenberger B, Wu W, Heck AJR. Kleinpenning F, et al. Among authors: heck ajr. Nat Commun. 2020 Jun 26;11(1):3244. doi: 10.1038/s41467-020-17010-0. Nat Commun. 2020. PMID: 32591520 Free PMC article.
Here, we adapt and combine these superb assets in a new enrichment strategy using phosphonate-handles, which we term PhosID. In this approach, click-able phosphonate-handles are introduced into proteins via 1,3-dipolar Huisgen-cycloaddition to azido-homo-alanine (AHA) and …
Here, we adapt and combine these superb assets in a new enrichment strategy using phosphonate-handles, which we term PhosID. In this …
Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice.
Muha V, Williamson R, Hills R, McNeilly AD, McWilliams TG, Alonso J, Schimpl M, Leney AC, Heck AJR, Sutherland C, Read KD, McCrimmon RJ, Brooks SP, van Aalten DMF. Muha V, et al. Among authors: heck ajr. Open Biol. 2019 Nov 29;9(11):190192. doi: 10.1098/rsob.190192. Epub 2019 Nov 27. Open Biol. 2019. PMID: 31771416 Free PMC article.
Parsimonious Charge Deconvolution for Native Mass Spectrometry.
Bern M, Caval T, Kil YJ, Tang W, Becker C, Carlson E, Kletter D, Sen KI, Galy N, Hagemans D, Franc V, Heck AJR. Bern M, et al. Among authors: heck ajr. J Proteome Res. 2018 Mar 2;17(3):1216-1226. doi: 10.1021/acs.jproteome.7b00839. Epub 2018 Feb 8. J Proteome Res. 2018. PMID: 29376659 Free PMC article.
When applied over a wide input m/z or broad target mass range, charge-deconvolution algorithms can produce artifacts, such as false masses at one-half or one-third of the correct mass. Indeed, a maximum entropy term in the objective function of MaxEnt, the most commonly us …
When applied over a wide input m/z or broad target mass range, charge-deconvolution algorithms can produce artifacts, such as false masses a …
Native Mass Spectrometry: What is in the Name?
Leney AC, Heck AJR. Leney AC, et al. Among authors: heck ajr. J Am Soc Mass Spectrom. 2017 Jan 1;28(1):5-13. doi: 10.1021/jasms.8b05378. J Am Soc Mass Spectrom. 2017. PMID: 32020797
In this perspective, we describe the origins of and (re)define the term native MS, portraying in detail what we meant by "native MS," when the term was coined and also describing what it does (according to us) not entail. ...
In this perspective, we describe the origins of and (re)define the term native MS, portraying in detail what we meant by "native MS," …
Native Mass Spectrometry: What is in the Name?
Leney AC, Heck AJ. Leney AC, et al. Among authors: heck aj. J Am Soc Mass Spectrom. 2017 Jan;28(1):5-13. doi: 10.1007/s13361-016-1545-3. Epub 2016 Dec 1. J Am Soc Mass Spectrom. 2017. PMID: 27909974 Free PMC article.
In this perspective, we describe the origins of and (re)define the term native MS, portraying in detail what we meant by "native MS," when the term was coined and also describing what it does (according to us) not entail. ...
In this perspective, we describe the origins of and (re)define the term native MS, portraying in detail what we meant by "native MS," …
Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse.
Corradini E, Vallur R, Raaijmakers LM, Feil S, Feil R, Heck AJ, Scholten A. Corradini E, et al. Among authors: heck aj. Mol Cell Proteomics. 2014 Aug;13(8):2004-16. doi: 10.1074/mcp.M113.035154. Epub 2014 Jun 12. Mol Cell Proteomics. 2014. PMID: 24925903 Free PMC article.
In this way, removal of cGKI could be linked to impaired cerebellar long-term depression at Purkinje cell synapses. In addition, we were able to identify a set of novel putative (phospho)proteins to be considered in this network. ...
In this way, removal of cGKI could be linked to impaired cerebellar long-term depression at Purkinje cell synapses. In addition, we w …
The effect of oxytocin and an oxytocin antagonist on the human myometrial proteome.
de Wit NC, Heck AJ, Thornton S. de Wit NC, et al. Among authors: heck aj. Reprod Sci. 2010 Jan;17(1):40-6. doi: 10.1177/1933719109345287. Epub 2009 Sep 18. Reprod Sci. 2010. PMID: 19767541
OBJECTIVE: The immediate effects of oxytocin on myometrial signal transduction have been described. However, the longer term effects (up to an hour) on the myometrial proteome have not. ...CONCLUSION: This study demonstrates that oxytocin has longer term (1 hour) ef …
OBJECTIVE: The immediate effects of oxytocin on myometrial signal transduction have been described. However, the longer term effects …
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