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Cofilin overactivation improves hippocampus-dependent short-term memory.
Raven F, Riemersma IW, Olthuis MF, Rybakovaite I, Meijer EL, Meerlo P, Van der Zee EA, Havekes R. Raven F, et al. Among authors: havekes r. Front Behav Neurosci. 2023 Aug 10;17:1243524. doi: 10.3389/fnbeh.2023.1243524. eCollection 2023. Front Behav Neurosci. 2023. PMID: 37638111 Free PMC article.
Many living organisms of the animal kingdom have the fundamental ability to form and retrieve memories. Most information is initially stored as short-term memory, which is then converted to a more stable long-term memory through a process called memory consolidation …
Many living organisms of the animal kingdom have the fundamental ability to form and retrieve memories. Most information is initially stored …
A brief period of sleep deprivation negatively impacts the acquisition, consolidation, and retrieval of object-location memories.
Heckman PRA, Roig Kuhn F, Meerlo P, Havekes R. Heckman PRA, et al. Among authors: havekes r. Neurobiol Learn Mem. 2020 Nov;175:107326. doi: 10.1016/j.nlm.2020.107326. Epub 2020 Oct 12. Neurobiol Learn Mem. 2020. PMID: 33059032 Free article.
Sleep deprivation is known to impair hippocampus-dependent long-term memories. Many studies have used extended periods of wakefulness, affecting all three memory processes, thereby making it unable to determine how each of the processes is affected by sleep loss, separatel …
Sleep deprivation is known to impair hippocampus-dependent long-term memories. Many studies have used extended periods of wakefulness …
Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling.
Bridi M, Schoch H, Florian C, Poplawski SG, Banerjee A, Hawk JD, Porcari GS, Lejards C, Hahn CG, Giese KP, Havekes R, Spruston N, Abel T. Bridi M, et al. Among authors: havekes r. JCI Insight. 2020 Mar 12;5(5):e92385. doi: 10.1172/jci.insight.92385. JCI Insight. 2020. PMID: 32069266 Free PMC article.
Long-term memory depends on the control of activity-dependent neuronal gene expression, which is regulated by epigenetic modifications. ...Here, we define a critical role for the corepressor SIN3A in memory and synaptic plasticity, showing that postnatal neuronal deletion …
Long-term memory depends on the control of activity-dependent neuronal gene expression, which is regulated by epigenetic modification …
Elucidating the role of protein synthesis in hippocampus-dependent memory consolidation across the day and night.
Raven F, Bolsius YG, van Renssen LV, Meijer EL, van der Zee EA, Meerlo P, Havekes R. Raven F, et al. Among authors: havekes r. Eur J Neurosci. 2021 Oct;54(8):6972-6981. doi: 10.1111/ejn.14684. Epub 2020 Feb 3. Eur J Neurosci. 2021. PMID: 31965655 Free PMC article.
It is widely acknowledged that de novo protein synthesis is crucial for the formation and consolidation of long-term memories. While the basal activity of many signaling cascades that modulate protein synthesis fluctuates in a circadian fashion, it is unclear whether the t …
It is widely acknowledged that de novo protein synthesis is crucial for the formation and consolidation of long-term memories. While …
Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.
Park AJ, Havekes R, Fu X, Hansen R, Tudor JC, Peixoto L, Li Z, Wu YC, Poplawski SG, Baraban JM, Abel T. Park AJ, et al. Among authors: havekes r. Elife. 2017 Sep 20;6:e27872. doi: 10.7554/eLife.27872. Elife. 2017. PMID: 28927503 Free PMC article.
We find that mice lacking translin/trax display defects in synaptic tagging, which requires protein synthesis at activated synapses, and long-term memory. Hippocampal samples harvested from these mice following learning show increases in several disease-related microRNAs t …
We find that mice lacking translin/trax display defects in synaptic tagging, which requires protein synthesis at activated synapses, and lon …
Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling.
Vogel Ciernia A, Kramár EA, Matheos DP, Havekes R, Hemstedt TJ, Magnan CN, Sakata K, Tran A, Azzawi S, Lopez A, Dang R, Wang W, Trieu B, Tong J, Barrett RM, Post RJ, Baldi P, Abel T, Lynch G, Wood MA. Vogel Ciernia A, et al. Among authors: havekes r. Learn Mem. 2017 Apr 17;24(5):199-209. doi: 10.1101/lm.044602.116. Print 2017 May. Learn Mem. 2017. PMID: 28416631 Free PMC article.
We generated transgenic mice lacking subdomain 2 of Baf53b (BAF53bdeltaSB2). Long-term synaptic potentiation (LTP) and long-term memory, both of which are associated with phosphorylation of the actin severing protein cofilin, were assessed in these animals. ...
We generated transgenic mice lacking subdomain 2 of Baf53b (BAF53bdeltaSB2). Long-term synaptic potentiation (LTP) and long-term …
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
Havekes R, Park AJ, Tolentino RE, Bruinenberg VM, Tudor JC, Lee Y, Hansen RT, Guercio LA, Linton E, Neves-Zaph SR, Meerlo P, Baillie GS, Houslay MD, Abel T. Havekes R, et al. J Neurosci. 2016 Aug 24;36(34):8936-46. doi: 10.1523/JNEUROSCI.0248-16.2016. J Neurosci. 2016. PMID: 27559174 Free PMC article.
However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo Here, we show that increasing protein levels of the PDE4A5 isoform in mouse hippocampal excitatory neurons impairs a long-lasting form of hippocampal synaptic plasticity and att …
However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo Here, we show that increasing protein …
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1.
Havekes R, Park AJ, Tudor JC, Luczak VG, Hansen RT, Ferri SL, Bruinenberg VM, Poplawski SG, Day JP, Aton SJ, Radwańska K, Meerlo P, Houslay MD, Baillie GS, Abel T. Havekes R, et al. Elife. 2016 Aug 23;5:e13424. doi: 10.7554/eLife.13424. Elife. 2016. PMID: 27549340 Free PMC article.
Suppression of cofilin function prevents spine loss, deficits in hippocampal synaptic plasticity, and impairments in long-term memory caused by sleep deprivation. The elevated cofilin activity is caused by cAMP-degrading phosphodiesterase-4A5 (PDE4A5), which hampers cAMP-P …
Suppression of cofilin function prevents spine loss, deficits in hippocampal synaptic plasticity, and impairments in long-term memory …
21 results