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Phase 2 Results Indicate Evenamide, A Selective Modulator of Glutamate Release, Is Associated With Clinically Important Long-Term Efficacy When Added to an Antipsychotic in Patients With Treatment-Resistant Schizophrenia.
Anand R, Turolla A, Chinellato G, Roy A, Hartman RD. Anand R, et al. Among authors: hartman rd. Int J Neuropsychopharmacol. 2023 Aug 29;26(8):523-528. doi: 10.1093/ijnp/pyad035. Int J Neuropsychopharmacol. 2023. PMID: 37349110 Free PMC article. Clinical Trial.
Impact of Prenatal Diagnosis of Critical Congenital Heart Disease on Preoperative and Postoperative Outcomes.
Dischinger AN, Li JS, Mulder H, Spears T, Chiswell KE, Hoffman TM, Hartman RJ, Walsh MJ, Sang CJ, Sarno LA, Paolillo JA, Welke K, D'Ottavio A, Sethi NJ. Dischinger AN, et al. Among authors: hartman rj. Pediatr Cardiol. 2023 Oct;44(7):1520-1528. doi: 10.1007/s00246-023-03197-8. Epub 2023 Jun 8. Pediatr Cardiol. 2023. PMID: 37289278
Patients with prenatal diagnosis had a lower incidence of preoperative risk factors, including need for mechanical ventilation and presence of shock. However, prenatally diagnosed patients had worse short-term outcomes, including higher operative mortality, higher incidenc …
Patients with prenatal diagnosis had a lower incidence of preoperative risk factors, including need for mechanical ventilation and presence …
An Epidemiologic Analysis of Melanoma Overdiagnosis in the United States, 1975-2017.
Kurtansky NR, Dusza SW, Halpern AC, Hartman RI, Geller AC, Marghoob AA, Rotemberg VM, Marchetti MA. Kurtansky NR, et al. Among authors: hartman ri. J Invest Dermatol. 2022 Jul;142(7):1804-1811.e6. doi: 10.1016/j.jid.2021.12.003. Epub 2021 Dec 11. J Invest Dermatol. 2022. PMID: 34902365 Free PMC article.
Cohort effects were identified for male and female mortality and male incidence but were not as apparent for female incidence, suggesting that period effects have had a greater influence on changes in incidence over time in females. Encouraging trends included long-term de …
Cohort effects were identified for male and female mortality and male incidence but were not as apparent for female incidence, suggesting th …
Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71.
Kozlova EV, Valdez MC, Denys ME, Bishay AE, Krum JM, Rabbani KM, Carrillo V, Gonzalez GM, Lampel G, Tran JD, Vazquez BM, Anchondo LM, Uddin SA, Huffman NM, Monarrez E, Olomi DS, Chinthirla BD, Hartman RE, Kodavanti PRS, Chompre G, Phillips AL, Stapleton HM, Henkelmann B, Schramm KW, Curras-Collazo MC. Kozlova EV, et al. Among authors: hartman re. Arch Toxicol. 2022 Jan;96(1):335-365. doi: 10.1007/s00204-021-03163-4. Epub 2021 Oct 23. Arch Toxicol. 2022. PMID: 34687351 Free PMC article.
Neurobehavioral testing of social novelty preference (SNP) and social recognition memory (SRM) revealed that adult L-DE-71 F1 offspring display deficient short- and long-term SRM, in the absence of reduced sociability, and increased repetitive behavior. These effects were …
Neurobehavioral testing of social novelty preference (SNP) and social recognition memory (SRM) revealed that adult L-DE-71 F1 offspring disp …
Glucagon: Its evolving role in the management of hypoglycemia.
Isaacs D, Clements J, Turco N, Hartman R. Isaacs D, et al. Among authors: hartman r. Pharmacotherapy. 2021 Jul;41(7):623-633. doi: 10.1002/phar.2534. Epub 2021 Jul 16. Pharmacotherapy. 2021. PMID: 33963599 Review.
Although glucagon has been commercially available since 1960, earlier formulations required reconstitution of a dry powder with diluent immediately prior to injection, due to lack of long-term stability once reconstituted. Glucagon has been underutilized due to the lack of …
Although glucagon has been commercially available since 1960, earlier formulations required reconstitution of a dry powder with diluent imme …
Nicotinamide for Keratinocyte Carcinoma Chemoprevention: A Nationwide Survey of Mohs Surgeons.
Desai S, Olbricht S, Ruiz ES, Hartman RI. Desai S, et al. Among authors: hartman ri. Dermatol Surg. 2021 Apr 1;47(4):452-453. doi: 10.1097/DSS.0000000000002788. Dermatol Surg. 2021. PMID: 33625146
Forty-five percent of respondents report a duration of use of 2 years or more in their patients. 63.8% of respondents had no concerns over nicotinamide's safety with long-term use. Individuals who answered "yes," "maybe," or "uncertain" to having safety concerns over long- …
Forty-five percent of respondents report a duration of use of 2 years or more in their patients. 63.8% of respondents had no concerns over n …
Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma.
Kompella UB, Hartman RR, Patil MA. Kompella UB, et al. Among authors: hartman rr. Prog Retin Eye Res. 2021 May;82:100901. doi: 10.1016/j.preteyeres.2020.100901. Epub 2020 Sep 4. Prog Retin Eye Res. 2021. PMID: 32891866 Free PMC article. Review.
Although once daily anti-glaucoma drug therapy is a current clinical reality, most therapies require multiple dosing and there is an unmet need to develop convenient, safe, and effective sustained release drug delivery systems for long-term treatment to improve patient adh …
Although once daily anti-glaucoma drug therapy is a current clinical reality, most therapies require multiple dosing and there is an unmet n …
Repeated isoflurane in adult male mice leads to acute and persistent motor decrements with long-term modifications in corpus callosum microstructural integrity.
Bajwa NM, Lee JB, Halavi S, Hartman RE, Obenaus A. Bajwa NM, et al. Among authors: hartman re. J Neurosci Res. 2019 Mar;97(3):332-345. doi: 10.1002/jnr.24343. Epub 2018 Nov 5. J Neurosci Res. 2019. PMID: 30394562
Although it has been reported as safe, recent findings suggest that despite widespread use, isoflurane-induced inhalational anesthesia can lead to various pathophysiological and cognitive alterations. Therefore, we aimed to investigate the long-term behavioral and white ma …
Although it has been reported as safe, recent findings suggest that despite widespread use, isoflurane-induced inhalational anesthesia can l …
Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D2 receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling.
van den Brink WJ, van den Berg DJ, Bonsel FEM, Hartman R, Wong YC, van der Graaf PH, de Lange ECM. van den Brink WJ, et al. Among authors: hartman r. Br J Pharmacol. 2018 Oct;175(19):3832-3843. doi: 10.1111/bph.14452. Epub 2018 Aug 31. Br J Pharmacol. 2018. PMID: 30051461 Free PMC article.
To improve the mechanistic insights into CNS drug effects, a plasma neuroendocrine fingerprint was identified using multi-biomarker pharmacokinetic/pharmacodynamic (PK/PD) modelling. Short- and long-term D(2) receptor activation was evaluated using quinpirole as a paradigm …
To improve the mechanistic insights into CNS drug effects, a plasma neuroendocrine fingerprint was identified using multi-biomarker pharmaco …
Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment.
Maloney SE, Creeley CE, Hartman RE, Yuede CM, Zorumski CF, Jevtovic-Todorovic V, Dikranian K, Noguchi KK, Farber NB, Wozniak DF. Maloney SE, et al. Among authors: hartman re. Neurobiol Learn Mem. 2019 Nov;165:106834. doi: 10.1016/j.nlm.2018.03.014. Epub 2018 Mar 14. Neurobiol Learn Mem. 2019. PMID: 29550366 Free PMC article. Review.
The results from ongoing studies indicate that, under certain conditions, exposure to these drugs during development induces an acute elevated apoptotic neurodegenerative response in the brain and long-term functional impairments. These animal models have played a signific …
The results from ongoing studies indicate that, under certain conditions, exposure to these drugs during development induces an acute elevat …
50 results