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Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia.
Course CW, Lewis PA, Kotecha SJ, Cousins M, Hart K, Heesom KJ, Watkins WJ, Kotecha S. Course CW, et al. Among authors: hart k. Sci Rep. 2023 Nov 9;13(1):19465. doi: 10.1038/s41598-023-46499-w. Sci Rep. 2023. PMID: 37945650 Free PMC article.
Preterm-born children are at risk of long-term pulmonary deficits, including those who developed bronchopulmonary dysplasia (BPD) in infancy, however the underlying mechanisms remain poorly understood. ...
Preterm-born children are at risk of long-term pulmonary deficits, including those who developed bronchopulmonary dysplasia (BPD) in …
Association of early and current life factors with telomere length in preterm-born children.
Kotecha EA, Zhang L, Aboklaish A, Cousins M, Hart K, Kotecha SJ, Watkins WJ, Kotecha S. Kotecha EA, et al. Among authors: hart k. PLoS One. 2023 Nov 8;18(11):e0293589. doi: 10.1371/journal.pone.0293589. eCollection 2023. PLoS One. 2023. PMID: 37939053 Free PMC article.
RESULTS: 534 children had satisfactory telomere data including 383 who were preterm-born (mean (SD) birthweight 1732g (558g), gestation 31.1 (2.6) weeks) and 151 term-born (3464g (510g); 39.8 (1.3) weeks). Telomere length was longer in children who had intrauterine growth …
RESULTS: 534 children had satisfactory telomere data including 383 who were preterm-born (mean (SD) birthweight 1732g (558g), gestation 31.1 …
Peripheral airway dysfunction in prematurity-associated obstructive lung disease identified by oscillometry.
Cousins M, Hart K, Radics BL, Henderson AJ, Hantos Z, Sly PD, Kotecha S. Cousins M, et al. Among authors: hart k. Pediatr Pulmonol. 2023 Nov;58(11):3279-3292. doi: 10.1002/ppul.26658. Epub 2023 Sep 13. Pediatr Pulmonol. 2023. PMID: 37701982 Free PMC article.
INTRODUCTION: Mechanisms underlying lung dysfunction after preterm birth are poorly understood. Studying phenotypes of prematurity-associated lung disease may aid understanding of underlying mechanisms. Preterm-born children with and without lung dysfunction and term …
INTRODUCTION: Mechanisms underlying lung dysfunction after preterm birth are poorly understood. Studying phenotypes of prematurity-as …
Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children.
Course CW, Lewis PA, Kotecha SJ, Cousins M, Hart K, Watkins WJ, Heesom KJ, Kotecha S. Course CW, et al. Among authors: hart k. Respir Res. 2023 Jul 20;24(1):191. doi: 10.1186/s12931-023-02494-3. Respir Res. 2023. PMID: 37474963 Free PMC article.
We, therefore, compared the urinary proteome for different spirometry phenotypes in preterm-born children with preterm- and term-born controls. METHODS: Preterm and term-born children aged 7-12 years, from the Respiratory Health Outcomes in Neonates (RHiNO) cohort, …
We, therefore, compared the urinary proteome for different spirometry phenotypes in preterm-born children with preterm- and term-born …
Do Patients Benefit from Micronutrient Supplementation following Pancreatico-Duodenectomy?
Phillips ME, Hart KH, Frampton AE, Robertson MD. Phillips ME, et al. Among authors: hart kh. Nutrients. 2023 Jun 19;15(12):2804. doi: 10.3390/nu15122804. Nutrients. 2023. PMID: 37375707 Free PMC article.
A retrospective review of medical notes was undertaken on 548 patients under long-term follow-up following PD in a tertiary hepato-pancreatico-biliary centre. ...
A retrospective review of medical notes was undertaken on 548 patients under long-term follow-up following PD in a tertiary hepato-pa …
Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia.
Course CW, Lewis PA, Kotecha SJ, Cousins M, Hart K, Watkins WJ, Heesom KJ, Kotecha S. Course CW, et al. Among authors: hart k. Sci Rep. 2023 May 5;13(1):7330. doi: 10.1038/s41598-023-34233-5. Sci Rep. 2023. PMID: 37147394 Free PMC article. Clinical Trial.
For the 19 proteins present in every sample, the desmosome proteins: desmoglein-1, desmocollin-1 and plakoglobin were significantly decreased, and cytokeratin-6A was increased in preterm-born children with BPD when compared to preterm- and term-born controls. ICS/LABA trea …
For the 19 proteins present in every sample, the desmosome proteins: desmoglein-1, desmocollin-1 and plakoglobin were significantly decrease …
Characterising airway obstructive, dysanaptic and PRISm phenotypes of prematurity-associated lung disease.
Cousins M, Hart K, Kotecha SJ, Henderson AJ, Watkins WJ, Bush A, Kotecha S. Cousins M, et al. Among authors: hart k. Thorax. 2023 Sep;78(9):895-903. doi: 10.1136/thorax-2022-219301. Epub 2023 Feb 1. Thorax. 2023. PMID: 36725332 Free PMC article.
RESULTS: 22.6% of 544 preterm-born (mean gestation: 31 weeks) and 9.2% of 195 term-born children, with satisfactory data available, were classified into one of four abnormal spirometry groups. ...By identifying specific phenotypes, targeted therapy can be developed to impr …
RESULTS: 22.6% of 544 preterm-born (mean gestation: 31 weeks) and 9.2% of 195 term-born children, with satisfactory data available, w …
Association of Gestation and Fetal Growth Restriction on Cardiovascular Health in Preterm-Born Children.
Course CW, Kotecha SJ, Cousins M, Hart K, Lowe J, Watkins WJ, Kotecha S. Course CW, et al. Among authors: hart k. J Pediatr. 2023 Apr;255:42-49.e4. doi: 10.1016/j.jpeds.2022.09.057. Epub 2022 Oct 12. J Pediatr. 2023. PMID: 36241052 Free PMC article.
OBJECTIVES: To prospectively evaluate the associations of early and current life factors, including gestational age and fetal growth restriction in preterm-born subjects, on cardiovascular health including measures of central and peripheral blood pressure and arterial stiffness a …
OBJECTIVES: To prospectively evaluate the associations of early and current life factors, including gestational age and fetal growth restric …
Image Phenotyping of Preterm-Born Children Using Hyperpolarized 129Xe Lung Magnetic Resonance Imaging and Multiple-Breath Washout.
Chan HF, Smith LJ, Biancardi AM, Bray J, Marshall H, Hughes PJC, Collier GJ, Rao M, Norquay G, Swift AJ, Hart K, Cousins M, Watkins WJ, Wild JM, Kotecha S. Chan HF, et al. Among authors: hart k. Am J Respir Crit Care Med. 2023 Jan 1;207(1):89-100. doi: 10.1164/rccm.202203-0606OC. Am J Respir Crit Care Med. 2023. PMID: 35972833 Free PMC article.
Rationale: Preterm birth is associated with low lung function in childhood, but little is known about the lung microstructure in childhood. ...Methods: Data were available from 63 children (aged 9-13 yr), including 44 born preterm (34 weeks' gestation) and 19 term-b …
Rationale: Preterm birth is associated with low lung function in childhood, but little is known about the lung microstructure in chil …
Impaired exercise outcomes with significant bronchodilator responsiveness in children with prematurity-associated obstructive lung disease.
Cousins M, Hart K, Williams EM, Kotecha S. Cousins M, et al. Among authors: hart k. Pediatr Pulmonol. 2022 Sep;57(9):2161-2171. doi: 10.1002/ppul.26019. Epub 2022 Jun 14. Pediatr Pulmonol. 2022. PMID: 35638186 Free PMC article.
INTRODUCTION: Preterm-born children have their normal in-utero lung development interrupted, thus are at risk of short- and long-term lung disease. Spirometry and exercise capacity impairments have been regularly reported in preterm-born children especially those who devel …
INTRODUCTION: Preterm-born children have their normal in-utero lung development interrupted, thus are at risk of short- and long-term …
53 results