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Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates.
Klinger AP, Travers CP, Martin A, Kuo HC, Alishlash AS, Harris WT, Carlo WA, Ambalavanan N. Klinger AP, et al. Among authors: harris wt. Pediatr Res. 2020 Aug;88(2):293-299. doi: 10.1038/s41390-020-0751-7. Epub 2020 Jan 14. Pediatr Res. 2020. PMID: 31935746 Free PMC article.
BACKGROUND: To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance (R) and lower reactance (X) on day 1. METHODS: Health …
BACKGROUND: To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypoth …
Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-5 years with cystic fibrosis and a CFTR gating mutation (KIWI): an open-label, single-arm study.
Davies JC, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Robertson S, Green Y, Cooke J, Rosenfeld M; KIWI Study Group. Davies JC, et al. Among authors: harris wt. Lancet Respir Med. 2016 Feb;4(2):107-15. doi: 10.1016/S2213-2600(15)00545-7. Epub 2016 Jan 21. Lancet Respir Med. 2016. PMID: 26803277 Free PMC article. Clinical Trial.
Participants received oral ivacaftor 50 mg (if bodyweight <14 kg) or 75 mg (if bodyweight 14 kg) every 12 h for 4 days in part A (to establish the short-term safety of doses for subsequent assessment in part B), and then for 24 weeks in part B (to assess safety and long …
Participants received oral ivacaftor 50 mg (if bodyweight <14 kg) or 75 mg (if bodyweight 14 kg) every 12 h for 4 days in part A (to esta …
Inhaled versus systemic antibiotics and airway inflammation in children with cystic fibrosis and Pseudomonas.
Noah TL, Ivins SS, Abode KA, Stewart PW, Michelson PH, Harris WT, Henry MM, Leigh MW. Noah TL, et al. Among authors: harris wt. Pediatr Pulmonol. 2010 Mar;45(3):281-90. doi: 10.1002/ppul.21176. Pediatr Pulmonol. 2010. PMID: 20146365 Clinical Trial.
CONCLUSIONS: In clinically stable children with CF, systemic antibiotics result in greater short-term reduction in lower airways inflammation than inhaled antibiotics....
CONCLUSIONS: In clinically stable children with CF, systemic antibiotics result in greater short-term reduction in lower airways infl …