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Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality.
O'Keefe EL, O'Keefe JH, Tintle NL, Westra J, Albuisson L, Harris WS. O'Keefe EL, et al. Among authors: harris ws. Mayo Clin Proc. 2024 Apr;99(4):534-541. doi: 10.1016/j.mayocp.2023.11.026. Epub 2024 Mar 20. Mayo Clin Proc. 2024. PMID: 38506781 Free article.
OBJECTIVE: To assess the associations of docosahexaenoic acid (DHA), a marine omega-3 fatty acid, with long-term all-cause mortality, cardiovascular (CV) mortality, and cancer mortality. ...
OBJECTIVE: To assess the associations of docosahexaenoic acid (DHA), a marine omega-3 fatty acid, with long-term all-cause mortality, …
Effect of six month's treatment with omega-3 acid ethyl esters on long-term outcomes after acute myocardial infarction: The OMEGA-REMODEL randomized clinical trial.
Bernhard B, Heydari B, Abdullah S, Francis SA, Lumish H, Wang W, Jerosch-Herold M, Harris WS, Kwong RY. Bernhard B, et al. Among authors: harris ws. Int J Cardiol. 2024 Mar 15;399:131698. doi: 10.1016/j.ijcard.2023.131698. Epub 2024 Jan 4. Int J Cardiol. 2024. PMID: 38184150 Clinical Trial.
BACKGROUND: Omega-3 polyunsaturated fatty acids (O3-FA) have been shown to reduce inflammation and adverse cardiac remodeling after acute myocardial infarction (AMI). However, the impact of O3-FA on long-term clinical outcomes remains uncertain. AIMS: To investigate the im …
BACKGROUND: Omega-3 polyunsaturated fatty acids (O3-FA) have been shown to reduce inflammation and adverse cardiac remodeling after acute my …
A Genome-Wide Interaction Study of Erythrocyte ω-3 Polyunsaturated Fatty Acid Species and Memory in the Framingham Heart Study Offspring Cohort.
Annevelink CE, Westra J, Sala-Vila A, Harris WS, Tintle NL, Shearer GC. Annevelink CE, et al. Among authors: harris ws. J Nutr. 2023 Dec 22:S0022-3166(23)72824-1. doi: 10.1016/j.tjnut.2023.12.035. Online ahead of print. J Nutr. 2023. PMID: 38141771
Several tests of cognition are utilized in the diagnosis of cognitive decline that assess executive function, short- and long-term memory, cognitive flexibility, and speech and motor control. ...We used linear mixed effects models to predict each of the 3 cognitive measure …
Several tests of cognition are utilized in the diagnosis of cognitive decline that assess executive function, short- and long-term me …
Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies.
Laguzzi F, Åkesson A, Marklund M, Qian F, Gigante B, Bartz TM, Bassett JK, Birukov A, Campos H, Hirakawa Y, Imamura F, Jäger S, Lankinen M, Murphy RA, Senn M, Tanaka T, Tintle N, Virtanen JK, Yamagishi K, Allison M, Brouwer IA, De Faire U, Eiriksdottir G, Ferrucci L, Forouhi NG, Geleijnse JM, Hodge AM, Kimura H, Laakso M, Risérus U, van Westing AC, Bandinelli S, Baylin A, Giles GG, Gudnason V, Iso H, Lemaitre RN, Ninomiya T, Post WS, Psaty BM, Salonen JT, Schulze MB, Tsai MY, Uusitupa M, Wareham NJ, Oh SW, Wood AC, Harris WS, Siscovick D, Mozaffarian D, Leander K; Fatty Acids and Outcomes Research Consortium (FORCE). Laguzzi F, et al. Among authors: harris ws. Circulation. 2024 Jan 23;149(4):305-316. doi: 10.1161/CIRCULATIONAHA.123.065530. Epub 2023 Dec 4. Circulation. 2024. PMID: 38047387 Free PMC article.
We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium. METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. ...RESULTS: After multivariable adjustments, a signif …
We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large cons …
Red Blood Cell DHA Is Inversely Associated with Risk of Incident Alzheimer's Disease and All-Cause Dementia: Framingham Offspring Study.
Sala-Vila A, Satizabal CL, Tintle N, Melo van Lent D, Vasan RS, Beiser AS, Seshadri S, Harris WS. Sala-Vila A, et al. Among authors: harris ws. Nutrients. 2022 Jun 9;14(12):2408. doi: 10.3390/nu14122408. Nutrients. 2022. PMID: 35745137 Free PMC article.
Red blood cell (RBC) status of DHA is an objective measure of long-term dietary DHA intake. In this prospective observational study conducted within the Framingham Offspring Cohort (1490 dementia-free participants aged 65 years old), we examined the association of RBC DHA …
Red blood cell (RBC) status of DHA is an objective measure of long-term dietary DHA intake. In this prospective observational study c …
Harmonizing blood DHA levels in pregnancy studies: An interlaboratory investigation.
Jackson KH, Harris WS. Jackson KH, et al. Among authors: harris ws. Prostaglandins Leukot Essent Fatty Acids. 2022 Apr;179:102417. doi: 10.1016/j.plefa.2022.102417. Epub 2022 Mar 23. Prostaglandins Leukot Essent Fatty Acids. 2022. PMID: 35390621
Recent trials in pregnant women on the effects of supplemental DHA on early preterm birth (ePTB) risk have shown that there is a maternal blood docosahexaenoic acid (DHA) level below which risk for ePTB was increased and supplemental DHA was effective at reducing risk. ...
Recent trials in pregnant women on the effects of supplemental DHA on early preterm birth (ePTB) risk have shown that there is a mate …
Red blood cell fatty acid patterns from 7 countries: Focus on the Omega-3 index.
Schuchardt JP, Cerrato M, Ceseri M, DeFina LF, Delgado GE, Gellert S, Hahn A, Howard BV, Kadota A, Kleber ME, Latini R, Maerz W, Manson JE, Mora S, Park Y, Sala-Vila A, von Schacky C, Sekikawa A, Tintle N, Tucker KL, Vasan RS, Harris WS. Schuchardt JP, et al. Among authors: harris ws. Prostaglandins Leukot Essent Fatty Acids. 2022 Apr;179:102418. doi: 10.1016/j.plefa.2022.102418. Epub 2022 Mar 24. Prostaglandins Leukot Essent Fatty Acids. 2022. PMID: 35366625 Free PMC article.
Red blood cell (RBC) fatty acid (FA) patterns are becoming recognized as long-term biomarkers of tissue FA composition, but different analytical methods have complicated inter-study and international comparisons. ...
Red blood cell (RBC) fatty acid (FA) patterns are becoming recognized as long-term biomarkers of tissue FA composition, but different …
Linoleic Acid Status in Cell Membranes Inversely Relates to the Prevalence of Symptomatic Carotid Artery Disease.
Lázaro I, Cofán M, Amor AJ, Ortega E, Freitas-Simoes TM, Llull L, Amaro S, Mestres G, Yugueros X, Harris WS, Riambau V, Sala-Vila A. Lázaro I, et al. Among authors: harris ws. Stroke. 2021 Jan;52(2):703-706. doi: 10.1161/STROKEAHA.120.030477. Epub 2020 Dec 4. Stroke. 2021. PMID: 33272124
BACKGROUND AND PURPOSE: The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomat …
BACKGROUND AND PURPOSE: The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty …
Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies.
Wu JHY, Marklund M, Imamura F, Tintle N, Ardisson Korat AV, de Goede J, Zhou X, Yang WS, de Oliveira Otto MC, Kröger J, Qureshi W, Virtanen JK, Bassett JK, Frazier-Wood AC, Lankinen M, Murphy RA, Rajaobelina K, Del Gobbo LC, Forouhi NG, Luben R, Khaw KT, Wareham N, Kalsbeek A, Veenstra J, Luo J, Hu FB, Lin HJ, Siscovick DS, Boeing H, Chen TA, Steffen B, Steffen LM, Hodge A, Eriksdottir G, Smith AV, Gudnason V, Harris TB, Brouwer IA, Berr C, Helmer C, Samieri C, Laakso M, Tsai MY, Giles GG, Nurmi T, Wagenknecht L, Schulze MB, Lemaitre RN, Chien KL, Soedamah-Muthu SS, Geleijnse JM, Sun Q, Harris WS, Lind L, Ärnlöv J, Riserus U, Micha R, Mozaffarian D; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE). Wu JHY, et al. Among authors: harris ws. Lancet Diabetes Endocrinol. 2017 Dec;5(12):965-974. doi: 10.1016/S2213-8587(17)30307-8. Epub 2017 Oct 12. Lancet Diabetes Endocrinol. 2017. PMID: 29032079 Free PMC article.
INTERPRETATION: Findings suggest that linoleic acid has long-term benefits for the prevention of type 2 diabetes and that arachidonic acid is not harmful. ...
INTERPRETATION: Findings suggest that linoleic acid has long-term benefits for the prevention of type 2 diabetes and that arachidonic …
Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid.
Allaire J, Harris WS, Vors C, Charest A, Marin J, Jackson KH, Tchernof A, Couture P, Lamarche B. Allaire J, et al. Among authors: harris ws. Prostaglandins Leukot Essent Fatty Acids. 2017 May;120:8-14. doi: 10.1016/j.plefa.2017.03.008. Epub 2017 Mar 31. Prostaglandins Leukot Essent Fatty Acids. 2017. PMID: 28515020 Free article. Clinical Trial.
The extent to which such differences between EPA and DHA in increasing the O3I relates to long-term cardiovascular risk needs to be investigated in the future....
The extent to which such differences between EPA and DHA in increasing the O3I relates to long-term cardiovascular risk needs to be i …
33 results