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Page 1
Disulfiram Treatment Normalizes Body Weight in Obese Mice.
Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, O'Sullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R. Bernier M, et al. Among authors: harney d. Cell Metab. 2020 Aug 4;32(2):203-214.e4. doi: 10.1016/j.cmet.2020.04.019. Epub 2020 May 14. Cell Metab. 2020. PMID: 32413333 Free PMC article.
Reductions in feeding efficiency and increases in energy expenditure were associated with body weight regulation in response to long-term disulfiram treatment. Loss of fat tissue and an increase in liver fenestrations were also observed in rats on disulfiram. ...
Reductions in feeding efficiency and increases in energy expenditure were associated with body weight regulation in response to long-term …
Human induced pluripotent stem cell-derived GABAergic interneuron transplants attenuate neuropathic pain.
Manion J, Khuong T, Harney D, Littleboy JB, Ruan T, Loo L, Costigan M, Larance M, Caron L, Neely GG. Manion J, et al. Among authors: harney d. Pain. 2020 Feb;161(2):379-387. doi: 10.1097/j.pain.0000000000001733. Pain. 2020. PMID: 31972853
Here, we extend these findings by showing, for the first time, that spinally transplanted, terminally differentiated human induced pluripotent stem cell-derived GABAergic (iGABAergic) neurons provide significant, long-term, and safe relief from neuropathic pain induced by …
Here, we extend these findings by showing, for the first time, that spinally transplanted, terminally differentiated human induced pluripote …
Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance.
Woodhouse RM, Buchmann G, Hoe M, Harney DJ, Low JKK, Larance M, Boag PR, Ashe A. Woodhouse RM, et al. Among authors: harney dj. Cell Rep. 2018 Nov 20;25(8):2259-2272.e5. doi: 10.1016/j.celrep.2018.10.085. Cell Rep. 2018. PMID: 30463020 Free article.
Here, we demonstrate that the putative histone methyltransferases SET-25 and SET-32 are required for establishment of a transgenerational silencing signal but not for long-term maintenance of this signal between subsequent generations, suggesting that transgenerational epi …
Here, we demonstrate that the putative histone methyltransferases SET-25 and SET-32 are required for establishment of a transgenerational si …
Influence of posture on the incidence of vein cannulation during epidural catheter placement.
Harney D, Moran CA, Whitty R, Harte S, Geary M, Gardiner J. Harney D, et al. Eur J Anaesthesiol. 2005 Feb;22(2):103-6. doi: 10.1017/s0265021505000190. Eur J Anaesthesiol. 2005. PMID: 15816587 Clinical Trial.
Following an initial observation of an apparently high incidence of epidural vein cannulation in the sitting position, a randomized trial was conducted to document whether such an association existed. METHODS: A total of 209 term parturients were randomized to either the s …
Following an initial observation of an apparently high incidence of epidural vein cannulation in the sitting position, a randomized trial wa …