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Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context.
Moreno E, Pandit SK, Toussaint MJM, Bongiovanni L, Harkema L, van Essen SC, van Liere EA, Westendorp B, de Bruin A. Moreno E, et al. Among authors: harkema l. Cancers (Basel). 2021 Apr 23;13(9):2033. doi: 10.3390/cancers13092033. Cancers (Basel). 2021. PMID: 33922435 Free PMC article.
To test whether atypical E2Fs can also function as oncogenes independent of RB loss, we induced long-term overexpression of E2f7 or E2f8 in mice. E2F7 and -8 overexpression increased the incidence of tumors in the lungs, but not in other tissues. ...
To test whether atypical E2Fs can also function as oncogenes independent of RB loss, we induced long-term overexpression of E2f7 or E …