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Fracture risk in adult patients treated with growth hormone replacement therapy for growth hormone deficiency: a prospective observational cohort study.
Mo D, Fleseriu M, Qi R, Jia N, Child CJ, Bouillon R, Hardin DS. Mo D, et al. Among authors: hardin ds. Lancet Diabetes Endocrinol. 2015 May;3(5):331-8. doi: 10.1016/S2213-8587(15)00098-4. Epub 2015 Apr 12. Lancet Diabetes Endocrinol. 2015. PMID: 25876453
BACKGROUND: To our knowledge, no controlled studies of the effects of long-term growth hormone replacement on fracture risk in adult patients with growth hormone deficiency exist. ...
BACKGROUND: To our knowledge, no controlled studies of the effects of long-term growth hormone replacement on fracture risk in adult …
Durability of glycemic control with insulin lispro mix 75/25 versus insulin glargine for older patients with type 2 diabetes.
Jovanovič L, Peters AL, Jiang HH, Hardin DS. Jovanovič L, et al. Among authors: hardin ds. Aging Clin Exp Res. 2014 Apr;26(2):115-21. doi: 10.1007/s40520-013-0140-8. Epub 2013 Oct 3. Aging Clin Exp Res. 2014. PMID: 24092662 Free PMC article. Clinical Trial.
BACKGROUND AND AIMS: Few studies have evaluated long-term durability of glycemic control in older patients. The aim of this study was to compare durability of glycemic control of twice-daily insulin lispro mix 75/25 (LM75/25; 75 % insulin lispro protamine suspension, 25 % …
BACKGROUND AND AIMS: Few studies have evaluated long-term durability of glycemic control in older patients. The aim of this study was …
Insulin resistance in Hispanic large-for-gestational-age neonates at birth.
Dyer JS, Rosenfeld CR, Rice J, Rice M, Hardin DS. Dyer JS, et al. Among authors: hardin ds. J Clin Endocrinol Metab. 2007 Oct;92(10):3836-43. doi: 10.1210/jc.2007-0079. Epub 2007 Jul 17. J Clin Endocrinol Metab. 2007. PMID: 17635945
DESIGN/PATIENTS/SETTING: Forty-two term Hispanic neonates were enrolled for cross-sectional studies at 24-48 h after birth and included nine large-for-gestational-age neonates delivered of women with gestational diabetes (large-for-gestational-age-IDM), 12 large-for …
DESIGN/PATIENTS/SETTING: Forty-two term Hispanic neonates were enrolled for cross-sectional studies at 24-48 h after birth and …
Twenty years of recombinant human growth hormone in children: relevance to pediatric care providers.
Hardin DS, Kemp SF, Allen DB. Hardin DS, et al. Clin Pediatr (Phila). 2007 May;46(4):279-86. doi: 10.1177/0009922806293924. Clin Pediatr (Phila). 2007. PMID: 17475983 Review.
Recent clinical studies that demonstrate the positive health benefits of recombinant human growth hormone in children with cystic fibrosis, inflammatory bowel disease, and juvenile rheumatoid arthritis have not yet clarified issues about patient selection and appropriate long- …
Recent clinical studies that demonstrate the positive health benefits of recombinant human growth hormone in children with cystic fibrosis, …
Guide to bone health and disease in cystic fibrosis.
Aris RM, Merkel PA, Bachrach LK, Borowitz DS, Boyle MP, Elkin SL, Guise TA, Hardin DS, Haworth CS, Holick MF, Joseph PM, O'Brien K, Tullis E, Watts NB, White TB. Aris RM, et al. Among authors: hardin ds. J Clin Endocrinol Metab. 2005 Mar;90(3):1888-96. doi: 10.1210/jc.2004-1629. Epub 2004 Dec 21. J Clin Endocrinol Metab. 2005. PMID: 15613415 Review.
The life span of these patients has increased from approximately 2 to 32 yr of age over the last three decades. Bone disease has emerged as a common complication in long-term survivors of CF. Some studies have observed that 50-75% of adults have low bone density and increa …
The life span of these patients has increased from approximately 2 to 32 yr of age over the last three decades. Bone disease has emerged as …
Protease inhibitor therapy improves protein catabolism in prepubertal children with HIV infection.
Hardin DS, Ellis KJ, Rice J, Doyle ME. Hardin DS, et al. J Pediatr Endocrinol Metab. 2004 Mar;17(3):321-5. doi: 10.1515/jpem.2004.17.3.321. J Pediatr Endocrinol Metab. 2004. PMID: 15112908
CONCLUSION: These results suggest that similar to HIV-infected adults, HIV-infected children have higher than normal protein catabolism. Furthermore, our measures suggest that short-term PI therapy results in improved protein catabolism and LTM....
CONCLUSION: These results suggest that similar to HIV-infected adults, HIV-infected children have higher than normal protein catabolism. Fur …
Growth problems and growth hormone treatment in children with cystic fibrosis.
Hardin DS. Hardin DS. J Pediatr Endocrinol Metab. 2002 May;15 Suppl 2:731-5. J Pediatr Endocrinol Metab. 2002. PMID: 12092687 Review.
A large multicenter trial is currently underway to assess the effect of long-term therapy with GH on the quality of life and pulmonary status....
A large multicenter trial is currently underway to assess the effect of long-term therapy with GH on the quality of life and pulmonar …
Treatment of type 2 diabetes mellitus in children and adolescents.
Zuhri-Yafi MI, Brosnan PG, Hardin DS. Zuhri-Yafi MI, et al. Among authors: hardin ds. J Pediatr Endocrinol Metab. 2002 Apr;15 Suppl 1:541-6. J Pediatr Endocrinol Metab. 2002. PMID: 12017229
CONCLUSION: Metformin appears to be an effective medication for the treatment of T2DM in children, but did not seem to be a sufficient long-term monotherapy in our protocol, which required euglycemia for insulin withdrawal. ...
CONCLUSION: Metformin appears to be an effective medication for the treatment of T2DM in children, but did not seem to be a sufficient long- …