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258 results

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Humanized mouse models for immuno-oncology research.
Chuprin J, Buettner H, Seedhom MO, Greiner DL, Keck JG, Ishikawa F, Shultz LD, Brehm MA. Chuprin J, et al. Nat Rev Clin Oncol. 2023 Mar;20(3):192-206. doi: 10.1038/s41571-022-00721-2. Epub 2023 Jan 12. Nat Rev Clin Oncol. 2023. PMID: 36635480 Free PMC article. Review.
Currently, the number of preclinical models that faithfully recapitulate interactions between the human immune system and tumours and enable evaluation of human-specific immunotherapies in vivo is limited. Humanized mice, a term that refers to immunodeficient mice co-engra …
Currently, the number of preclinical models that faithfully recapitulate interactions between the human immune system and tumours and enable …
Craniopharyngioma.
Müller HL, Merchant TE, Warmuth-Metz M, Martinez-Barbera JP, Puget S. Müller HL, et al. Nat Rev Dis Primers. 2019 Nov 7;5(1):75. doi: 10.1038/s41572-019-0125-9. Nat Rev Dis Primers. 2019. PMID: 31699993 Review.
ACPs are driven by somatic mutations in CTNNB1 (encoding beta-catenin) that affect beta-catenin stability and are predominantly cystic in appearance. PCPs frequently harbour somatic BRAF(V600E) mutations and are typically solid tumours. ...Treatment comprises neurosurgery …
ACPs are driven by somatic mutations in CTNNB1 (encoding beta-catenin) that affect beta-catenin stability and are predominantly cystic in ap …
Sauna use as a lifestyle practice to extend healthspan.
Patrick RP, Johnson TL. Patrick RP, et al. Exp Gerontol. 2021 Oct 15;154:111509. doi: 10.1016/j.exger.2021.111509. Epub 2021 Aug 5. Exp Gerontol. 2021. PMID: 34363927 Free article. Review.
Sauna use, sometimes referred to as "sauna bathing," is characterized by short-term passive exposure to high temperatures, typically ranging from 45 C to 100 C (113 F to 212 F), depending on modality. ...
Sauna use, sometimes referred to as "sauna bathing," is characterized by short-term passive exposure to high temperatures, typically …
Hallmarks of cancer stem cell metabolism.
Sancho P, Barneda D, Heeschen C. Sancho P, et al. Br J Cancer. 2016 Jun 14;114(12):1305-12. doi: 10.1038/bjc.2016.152. Epub 2016 May 24. Br J Cancer. 2016. PMID: 27219018 Free PMC article. Review.
However, tumours are not uniform, but rather functionally heterogeneous and harbour a subset of cancer cells with stemness features. Such cancer cells have the ability to repopulate the entire tumour and thus have been termed cancer stem cells (CSCs) or tumour-initiating c …
However, tumours are not uniform, but rather functionally heterogeneous and harbour a subset of cancer cells with stemness features. …
The role of TH17 cells in multiple sclerosis: Therapeutic implications.
Moser T, Akgün K, Proschmann U, Sellner J, Ziemssen T. Moser T, et al. Autoimmun Rev. 2020 Oct;19(10):102647. doi: 10.1016/j.autrev.2020.102647. Epub 2020 Aug 13. Autoimmun Rev. 2020. PMID: 32801039 Review.
Fingolimod and alemtuzumab induce a paramount decrease in central memory T cells, which harbour the majority of peripheral TH17 cells, while the efficacy of natalizumab, dimethyl fumarate and importantly hematopoietic stem cell therapy correlates with TH17.1 cell in …
Fingolimod and alemtuzumab induce a paramount decrease in central memory T cells, which harbour the majority of peripheral TH1 …
Mechanisms of Resistance and Treatment of Relapse after CAR T-cell Therapy for Large B-cell Lymphoma and Multiple Myeloma.
Rejeski K, Jain MD, Smith EL. Rejeski K, et al. Transplant Cell Ther. 2023 Jul;29(7):418-428. doi: 10.1016/j.jtct.2023.04.007. Epub 2023 Apr 17. Transplant Cell Ther. 2023. PMID: 37076102 Review.
Although chimeric antigen receptor (CAR) T cell therapy (CAR-T) has altered the treatment landscape for relapsed/refractory B cell malignancies and multiple myeloma, only a minority of patients attain long-term disease remission. The underlying reasons for CA …
Although chimeric antigen receptor (CAR) T cell therapy (CAR-T) has altered the treatment landscape for relapsed/refractory B …
Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study.
Chesney J, Lewis KD, Kluger H, Hamid O, Whitman E, Thomas S, Wermke M, Cusnir M, Domingo-Musibay E, Phan GQ, Kirkwood JM, Hassel JC, Orloff M, Larkin J, Weber J, Furness AJS, Khushalani NI, Medina T, Egger ME, Graf Finckenstein F, Jagasia M, Hari P, Sulur G, Shi W, Wu X, Sarnaik A. Chesney J, et al. J Immunother Cancer. 2022 Dec;10(12):e005755. doi: 10.1136/jitc-2022-005755. J Immunother Cancer. 2022. PMID: 36600653 Free PMC article. Clinical Trial.
RESULTS: The Full Analysis Set consisted of 153 patients treated with lifileucel, including longer-term follow-up on the 66 patients previously reported. Patients had received a median of 3.0 lines of prior therapy (81.7% received both anti-programmed cell death protein 1 …
RESULTS: The Full Analysis Set consisted of 153 patients treated with lifileucel, including longer-term follow-up on the 66 patients …
From mucosal infection to successful cancer immunotherapy.
Goubet AG, Rouanne M, Derosa L, Kroemer G, Zitvogel L. Goubet AG, et al. Nat Rev Urol. 2023 Nov;20(11):682-700. doi: 10.1038/s41585-023-00784-5. Epub 2023 Jul 11. Nat Rev Urol. 2023. PMID: 37433926 Review.
ICBs reinstate or bolster pre-existing immune responses while creating new T cell specificities. Immunogenic cancers, which tend to benefit more from immunotherapy than cold tumours, harbour tumour-specific neoantigens, often associated with a high tumour mutational …
ICBs reinstate or bolster pre-existing immune responses while creating new T cell specificities. Immunogenic cancers, which tend to b …
Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer: a patient-level meta-analysis of 100 000 women from 86 randomised trials.
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Electronic address: bc.overview@ctsu.ox.ac.uk; Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Electronic address: bc.overview@ctsu.ox.ac.uk, et al. Lancet. 2023 Apr 15;401(10384):1277-1292. doi: 10.1016/S0140-6736(23)00285-4. Lancet. 2023. PMID: 37061269 Free PMC article.
BACKGROUND: Anthracycline-taxane chemotherapy for early-stage breast cancer substantially improves survival compared with no chemotherapy. However, concerns about short-term and long-term side-effects of anthracyclines have led to increased use of taxane chemotherap …
BACKGROUND: Anthracycline-taxane chemotherapy for early-stage breast cancer substantially improves survival compared with no chemotherapy. H …
Recovery of gut microbiota of healthy adults following antibiotic exposure.
Palleja A, Mikkelsen KH, Forslund SK, Kashani A, Allin KH, Nielsen T, Hansen TH, Liang S, Feng Q, Zhang C, Pyl PT, Coelho LP, Yang H, Wang J, Typas A, Nielsen MF, Nielsen HB, Bork P, Wang J, Vilsbøll T, Hansen T, Knop FK, Arumugam M, Pedersen O. Palleja A, et al. Nat Microbiol. 2018 Nov;3(11):1255-1265. doi: 10.1038/s41564-018-0257-9. Epub 2018 Oct 22. Nat Microbiol. 2018. PMID: 30349083
To minimize the impact of antibiotics, gut microorganisms harbour and exchange antibiotics resistance genes, collectively called their resistome. ...Despite a mild yet long-lasting imprint following antibiotics exposure, the gut microbiota of healthy young adults are resil …
To minimize the impact of antibiotics, gut microorganisms harbour and exchange antibiotics resistance genes, collectively called thei …
258 results