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Changes in the R-region interactions depend on phosphorylation and contribute to PKA and PKC regulation of the cystic fibrosis transmembrane conductance regulator chloride channel.
FASEB Bioadv. 2019 Dec 24;2(1):33-48. doi: 10.1096/fba.2019-00053. eCollection 2020 Jan.
FASEB Bioadv. 2019.
PMID: 32123855
Free PMC article.
The CFTR chloride channel is regulated by phosphorylation at PKA and PKC consensus sites within its regulatory region (R-region) through a mechanism, which is still not completely understood. We used a split-CFTR construct expressing the N-term-TMD1-NBD1 (Front Half; FH), …
The CFTR chloride channel is regulated by phosphorylation at PKA and PKC consensus sites within its regulatory region (R-region) through a m …
Altered channel properties of porins from Haemophilus influenzae: isolates from cystic fibrosis patients.
Arbing MA, Hanrahan JW, Coulton JW.
Arbing MA, et al. Among authors: hanrahan jw.
J Membr Biol. 2002 Sep 15;189(2):131-41. doi: 10.1007/s00232-002-1008-6.
J Membr Biol. 2002.
PMID: 12235488
Changes in amino-acid sequence of the unique pore-forming protein of H. influenzae (OmpP2; porin) have been associated with increased antimicrobial resistance in H. influenzae strains isolated from cystic fibrosis patients. From patients who were subjected to long-term ant …
Changes in amino-acid sequence of the unique pore-forming protein of H. influenzae (OmpP2; porin) have been associated with increased antimi …
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Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A.
Jia Y, Mathews CJ, Hanrahan JW.
Jia Y, et al. Among authors: hanrahan jw.
J Biol Chem. 1997 Feb 21;272(8):4978-84. doi: 10.1074/jbc.272.8.4978.
J Biol Chem. 1997.
PMID: 9030559
Free article.
PKC enhanced PKA stimulation of open probability without increasing the number of functional channels. Short-term pretreatment of cells with the PKC inhibitor chelerythrine (1 microM) reduced the channel activity that could be elicited by forskolin in cell-attached patches …
PKC enhanced PKA stimulation of open probability without increasing the number of functional channels. Short-term pretreatment of cel …
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Plasma membrane Na+/H+ exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways.
Kandasamy RA, Yu FH, Harris R, Boucher A, Hanrahan JW, Orlowski J.
Kandasamy RA, et al. Among authors: hanrahan jw.
J Biol Chem. 1995 Dec 8;270(49):29209-16. doi: 10.1074/jbc.270.49.29209.
J Biol Chem. 1995.
PMID: 7493949
Free article.
Incubation of cells with either AIF4-, a general agonist of G proteins, or cholera toxin, a selective activator of G alpha s that stimulates adenylate cyclase, accelerated the rates of amiloride-inhibitable 22Na+ influx mediated by NHE-1 and -2, whereas they inhibited that by NHE …
Incubation of cells with either AIF4-, a general agonist of G proteins, or cholera toxin, a selective activator of G alpha s that stimulates …
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