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Exercise Training Attenuates the Muscle Mitochondria Genomic Response to Bed Rest.
Cotter JA, Plaza-Florido A, Adams GR, Haddad F, Scott JM, Everett M, Ploutz-Snyder L, Radom-Aizik S. Cotter JA, et al. Among authors: haddad f. Med Sci Sports Exerc. 2024 Apr 23. doi: 10.1249/MSS.0000000000003457. Online ahead of print. Med Sci Sports Exerc. 2024. PMID: 38650118
CONCLUSIONS: Mitochondrial gene expression was a significant component of the molecular response to long-term bed rest. While exercise attenuated the FC in the downregulation of many genes, it did not completely counteract all the molecular consequences....
CONCLUSIONS: Mitochondrial gene expression was a significant component of the molecular response to long-term bed rest. While exercis …
A prospective randomized controlled trial comparing CT-based planning with conventional total hip arthroplasty versus robotic arm-assisted total hip arthroplasty.
Fontalis A, Kayani B, Plastow R, Giebaly DE, Tahmassebi J, Haddad IC, Chambers A, Mancino F, Konan S, Haddad FS. Fontalis A, et al. Among authors: haddad fs. Bone Joint J. 2024 Apr 1;106-B(4):324-335. doi: 10.1302/0301-620X.106B4.BJJ-2023-1045.R1. Bone Joint J. 2024. PMID: 38555946 Clinical Trial.
CONCLUSION: This RCT suggested that robotic-arm assistance in THA was associated with improved accuracy in restoring the native COR, better preservation of the combined offset, leg length correction, and superior accuracy in achieving the desired acetabular component positioning. …
CONCLUSION: This RCT suggested that robotic-arm assistance in THA was associated with improved accuracy in restoring the native COR, better …
Navigating the Management of Chronic Phase CML in the Era of Generic BCR::ABL1 Tyrosine Kinase Inhibitors.
Haddad FG, Kantarjian H. Haddad FG, et al. J Natl Compr Canc Netw. 2024 Feb;22(1):e237116. doi: 10.6004/jnccn.2023.7116. J Natl Compr Canc Netw. 2024. PMID: 38394773 Review.
Dose-adjusted ponatinib schedules have demonstrated improved efficacy and safety in patients resistant to second-generation TKIs or those with T315I-mutated disease. For asciminib, longer-term follow-up is needed to better evaluate its safety and efficacy compared with pon …
Dose-adjusted ponatinib schedules have demonstrated improved efficacy and safety in patients resistant to second-generation TKIs or those wi …
Robotic trials in arthroplasty surgery.
Khatri C, Metcalfe A, Wall P, Underwood M, Haddad FS, Davis ET. Khatri C, et al. Among authors: haddad fs. Bone Joint J. 2024 Feb 1;106-B(2):114-120. doi: 10.1302/0301-620X.106B2.BJJ-2023-0711.R1. Bone Joint J. 2024. PMID: 38295854
Secondary outcomes include early pain, the alignment of the components, and medium- to long-term outcomes. This annotation outlines the need to assess these technologies and discusses the design and challenges when conducting such trials, including surgical workflows, isol …
Secondary outcomes include early pain, the alignment of the components, and medium- to long-term outcomes. This annotation outlines t …
SOHO State of the Art Updates and Next Questions: Update on the Approach to Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
Haddad FG, Jabbour E, Short NJ, Jain N, Kantarjian H. Haddad FG, et al. Clin Lymphoma Myeloma Leuk. 2024 May;24(5):271-276. doi: 10.1016/j.clml.2023.12.007. Epub 2023 Dec 14. Clin Lymphoma Myeloma Leuk. 2024. PMID: 38185587 Review.
Achieving a complete molecular remission (CMR; disappearance of the BCR::ABL1 transcripts) within the first 3 months of therapy is an important endpoint in newly diagnosed Ph-positive ALL that identifies patients who have an excellent long-term survival and who may not nee …
Achieving a complete molecular remission (CMR; disappearance of the BCR::ABL1 transcripts) within the first 3 months of therapy is an import …
Short term outcomes following robotic arm-assisted lateral unicompartmental knee arthroplasty.
Wignadasan W, Chang J, Fontalis A, Plastow R, Haddad FS. Wignadasan W, et al. Among authors: haddad fs. Front Surg. 2023 Dec 15;10:1215280. doi: 10.3389/fsurg.2023.1215280. eCollection 2023. Front Surg. 2023. PMID: 38162087 Free PMC article.
However, there is paucity of evidence regarding outcomes following RA-UKA for isolated lateral compartment osteoarthritis. The purpose of this study was to assess the short-term clinical and patient reported outcomes of lateral compartment UKA, utilising robotic-arm assist …
However, there is paucity of evidence regarding outcomes following RA-UKA for isolated lateral compartment osteoarthritis. The purpose of th …
Cognitive functions of patients treated with chemotherapy: A comparative study.
Bou Khalil R, Haddad F, Cordahi CC, Fiani D, Moukarzel JM, Chamoun Y, Kourie HR, Richa S, Kattan J. Bou Khalil R, et al. Among authors: haddad f. Encephale. 2023 Nov 30:S0013-7006(23)00205-1. doi: 10.1016/j.encep.2023.10.001. Online ahead of print. Encephale. 2023. PMID: 38040507
OBJECTIVES: Chemobrain is a well-established clinical syndrome that has become an increasing concern because of the growing number of long-term cancer survivors. It refers to the post-chemotherapy related cognitive dysfunction. ...
OBJECTIVES: Chemobrain is a well-established clinical syndrome that has become an increasing concern because of the growing number of long- …
Length of stay and discharge dispositions following robotic arm-assisted total knee arthroplasty and unicompartmental knee arthroplasty versus conventional technique and predictors of delayed discharge.
Fontalis A, Raj RD, Haddad IC, Donovan C, Plastow R, Oussedik S, Gabr A, Haddad FS. Fontalis A, et al. Among authors: haddad fs. Bone Jt Open. 2023 Oct 19;4(10):791-800. doi: 10.1302/2633-1462.410.BJO-2023-0126.R1. Bone Jt Open. 2023. PMID: 37852620 Free PMC article.
Our results suggest that robotic arm assistance could be advantageous in partly addressing the upsurge of knee arthroplasty procedures and the concomitant healthcare burden; however, this needs to be corroborated by long-term cost-effectiveness analyses and data from rando …
Our results suggest that robotic arm assistance could be advantageous in partly addressing the upsurge of knee arthroplasty procedures and t …
Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation treated in the pre- and post-ponatinib era.
Haddad FG, Sasaki K, Bidikian A, Issa GC, Kadia T, Jain N, Alvarado Y, Short NJ, Pemmaraju N, Loghavi S, Patel KP, Kanagal-Shamanna R, Yilmaz M, Masarova L, Jabbour E, Kantarjian H. Haddad FG, et al. Am J Hematol. 2023 Oct;98(10):1619-1626. doi: 10.1002/ajh.27037. Epub 2023 Jul 23. Am J Hematol. 2023. PMID: 37485584
In summary, patients with CML-CP at the time of T315I mutation detection may have a relatively indolent disease course with a long-term OS of 70%. Treatment with third-generation tyrosine kinase inhibitors seemed to improve survival in patients with CML-CP....
In summary, patients with CML-CP at the time of T315I mutation detection may have a relatively indolent disease course with a long-term …
Artificial intelligence in orthopaedic surgery.
Lisacek-Kiosoglous AB, Powling AS, Fontalis A, Gabr A, Mazomenos E, Haddad FS. Lisacek-Kiosoglous AB, et al. Among authors: haddad fs. Bone Joint Res. 2023 Jul 10;12(7):447-454. doi: 10.1302/2046-3758.127.BJR-2023-0111.R1. Bone Joint Res. 2023. PMID: 37423607 Free PMC article.
The use of artificial intelligence (AI) is rapidly growing across many domains, of which the medical field is no exception. AI is an umbrella term defining the practical application of algorithms to generate useful output, without the need of human cognition. ...
The use of artificial intelligence (AI) is rapidly growing across many domains, of which the medical field is no exception. AI is an umbrell …
149 results