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1995 2
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Page 1
Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway.
Esther CR Jr, Sesma JI, Dohlman HG, Ault AD, Clas ML, Lazarowski ER, Boucher RC. Esther CR Jr, et al. Biochemistry. 2008 Sep 2;47(35):9269-78. doi: 10.1021/bi800855k. Epub 2008 Aug 12. Biochemistry. 2008. PMID: 18693752 Free PMC article.
Indeed, total adenine nucleotide release, like UDP-glucose release, did not vary with glucose concentration over the short term. The genetic basis of UDP-glucose release was explored through analysis of deletion mutants, aided by development of a novel bioassay for UDP-glu …
Indeed, total adenine nucleotide release, like UDP-glucose release, did not vary with glucose concentration over the short term. The …
Mucus clearance and lung function in cystic fibrosis with hypertonic saline.
Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. Donaldson SH, et al. N Engl J Med. 2006 Jan 19;354(3):241-50. doi: 10.1056/NEJMoa043891. N Engl J Med. 2006. PMID: 16421365 Free article. Clinical Trial.
Mucus clearance and lung function were measured during 14-day baseline and treatment periods. RESULTS: Long-term inhalation of hypertonic saline without pretreatment with amiloride (i.e., with placebo pretreatment) resulted in a sustained (> or =8 hours) increase in 1-h …
Mucus clearance and lung function were measured during 14-day baseline and treatment periods. RESULTS: Long-term inhalation of hypert …
Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors.
Jacobson KA, Costanzi S, Ivanov AA, Tchilibon S, Besada P, Gao ZG, Maddileti S, Harden TK. Jacobson KA, et al. Biochem Pharmacol. 2006 Feb 14;71(4):540-9. doi: 10.1016/j.bcp.2005.11.010. Epub 2005 Dec 15. Biochem Pharmacol. 2006. PMID: 16359641 Free PMC article.
With the long-term goal of developing receptor subtype-selective high affinity agonists for the uracil nucleotide-activated P2Y receptors we have carried out a series of structure activity and molecular modeling studies of the human P2Y2 and P2Y4 receptors. ...
With the long-term goal of developing receptor subtype-selective high affinity agonists for the uracil nucleotide-activated P2Y recep …
Chronic airway infection/inflammation induces a Ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia.
Ribeiro CM, Paradiso AM, Schwab U, Perez-Vilar J, Jones L, O'neal W, Boucher RC. Ribeiro CM, et al. J Biol Chem. 2005 May 6;280(18):17798-806. doi: 10.1074/jbc.M410618200. Epub 2005 Mar 3. J Biol Chem. 2005. PMID: 15746099 Free article.
We found that DeltaF508 CF bronchial epithelia were hyperinflammatory as defined by an increased basal and mucosal BK-induced interleukin (IL)-8 secretion. However, the CF hyperinflammation expressed in short-term (6-11-day-old) primary cultures of DeltaF508 bronchial epit …
We found that DeltaF508 CF bronchial epithelia were hyperinflammatory as defined by an increased basal and mucosal BK-induced interleukin (I …
Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia.
Ribeiro CM, Paradiso AM, Carew MA, Shears SB, Boucher RC. Ribeiro CM, et al. J Biol Chem. 2005 Mar 18;280(11):10202-9. doi: 10.1074/jbc.M410617200. Epub 2005 Jan 12. J Biol Chem. 2005. PMID: 15647273 Free article.
Third, apical ER density and P2Y(2)-R activation-mobilized Ca(2+)(i), which were investigated in airway epithelia in a long term culture in the absence of luminal infection, were similar in normal and CF epithelia. ...
Third, apical ER density and P2Y(2)-R activation-mobilized Ca(2+)(i), which were investigated in airway epithelia in a long term cult …
Pharmacologic modulation of salt and water in the airway epithelium in cystic fibrosis.
Knowles MR, Olivier K, Noone P, Boucher RC. Knowles MR, et al. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 2):S65-9. doi: 10.1164/ajrccm/151.3_Pt_2.S65. Am J Respir Crit Care Med. 1995. PMID: 7533608 Review.
Phase III studies of amiloride in adults and adolescents are underway, and short-term safety studies in children are under way. Aerosolized uridine triphosphate (UTP) induces Cl- secretion in CF airway epithelia via non-CFTR Cl- channels. ...
Phase III studies of amiloride in adults and adolescents are underway, and short-term safety studies in children are under way. Aeros …
Pharmacologic treatment of abnormal ion transport in the airway epithelium in cystic fibrosis.
Knowles MR, Olivier KN, Hohneker KW, Robinson J, Bennett WD, Boucher RC. Knowles MR, et al. Chest. 1995 Feb;107(2 Suppl):71S-76S. doi: 10.1378/chest.107.2_supplement.71s. Chest. 1995. PMID: 7842817 Review.
Clinical trials of amiloride are currently underway in adults and adolescents, and short-term safety studies have been initiated in children. Aerosolized uridine triphosphate (UTP) induces Cl- (and liquid) secretion in CF airway epithelia via non-CFTR Cl- channels. Short- …
Clinical trials of amiloride are currently underway in adults and adolescents, and short-term safety studies have been initiated in c …