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Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils.
Cell Rep Med. 2021 Apr 8;2(4):100239. doi: 10.1016/j.xcrm.2021.100239. eCollection 2021 Apr 20.
Cell Rep Med. 2021.
PMID: 33948572
Free PMC article.
Treatment by the RNA polymerase II and III inhibitor alpha-amanitin restores the expression of key antimicrobial genes and increases the bactericidal capacity of CF airway neutrophils in vitro and in short-term sputum cultures ex vivo. Broadly, our findings show that neutr …
Treatment by the RNA polymerase II and III inhibitor alpha-amanitin restores the expression of key antimicrobial genes and increases the bac …
MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha.
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber GS, Gaggar A, Tipple TE, Ambalavanan N, Lal CV.
Freeman A, et al.
Respir Res. 2021 Feb 17;22(1):57. doi: 10.1186/s12931-021-01654-7.
Respir Res. 2021.
PMID: 33596914
Free PMC article.
METHODS: Here we report a prospective cohort study of extremely preterm neonates wherein infants diagnosed with severe BPD expressed increased airway miR-219-5p and decreased platelet derived growth factor receptor alpha (PDGFR-alpha), a target of mir-219-5p and a key regulator o …
METHODS: Here we report a prospective cohort study of extremely preterm neonates wherein infants diagnosed with severe BPD expressed increas …
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