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Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection.
Cho JL, Villacreses R, Nagpal P, Guo J, Pezzulo AA, Thurman AL, Hamzeh NY, Blount RJ, Fortis S, Hoffman EA, Zabner J, Comellas AP. Cho JL, et al. Radiology. 2022 Jul;304(1):185-192. doi: 10.1148/radiol.212170. Epub 2022 Mar 15. Radiology. 2022. PMID: 35289657 Free PMC article.
Background The long-term effects of SARS-CoV-2 infection on pulmonary structure and function remain incompletely characterized. ...Conclusion In survivors of COVID-19, small airways disease occurred independently of initial infection severity. The long-term conseque …
Background The long-term effects of SARS-CoV-2 infection on pulmonary structure and function remain incompletely characterized. ...Co …
Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia.
Krishnamurthy S, Wohlford-Lenane C, Kandimalla S, Sartre G, Meyerholz DK, Théberge V, Hallée S, Duperré AM, Del'Guidice T, Lepetit-Stoffaes JP, Barbeau X, Guay D, McCray PB Jr. Krishnamurthy S, et al. Nat Commun. 2019 Oct 28;10(1):4906. doi: 10.1038/s41467-019-12922-y. Nat Commun. 2019. PMID: 31659165 Free PMC article.
Instillation of shuttle peptides combined with SpCas9 or AsCas12a RNP achieves editing of loxP sites in airway epithelia of ROSA(mT/mG) mice. We observe no evidence of short-term toxicity with a widespread distribution restricted to the respiratory tract. ...
Instillation of shuttle peptides combined with SpCas9 or AsCas12a RNP achieves editing of loxP sites in airway epithelia of ROSA(mT/mG) mice …
A Novel AAV-mediated Gene Delivery System Corrects CFTR Function in Pigs.
Cooney AL, Thornell IM, Singh BK, Shah VS, Stoltz DA, McCray PB Jr, Zabner J, Sinn PL. Cooney AL, et al. Am J Respir Cell Mol Biol. 2019 Dec;61(6):747-754. doi: 10.1165/rcmb.2019-0006OC. Am J Respir Cell Mol Biol. 2019. PMID: 31184507 Free PMC article.
Because of the packaging constraints of AAV, careful consideration was required to ensure that the vector would package and express its CFTR cDNA cargo. In this short-term study, PB/AAV-CFTR was aerosolized to the airways of CF pigs in the absence of the transposase. ...
Because of the packaging constraints of AAV, careful consideration was required to ensure that the vector would package and express its CFTR …
Lentiviral Vectors for the Treatment and Prevention of Cystic Fibrosis Lung Disease.
Marquez Loza LI, Yuen EC, McCray PB Jr. Marquez Loza LI, et al. Genes (Basel). 2019 Mar 14;10(3):218. doi: 10.3390/genes10030218. Genes (Basel). 2019. PMID: 30875857 Free PMC article. Review.
Lentiviral vectors are well-suited for this purpose because they transduce nondividing cells, and provide long-term transgene expression. Studies in primary cultures of human CF airway epithelia and CF animal models demonstrate the long-term correction of CF phenoty …
Lentiviral vectors are well-suited for this purpose because they transduce nondividing cells, and provide long-term transgene express …