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Page 1
Gene therapy encoding cell cycle factors to treat chronic ischemic heart failure in rats.
Abouleisa RRE, Tang XL, Ou Q, Salama AM, Woolard A, Hammouri D, Abdelhafez H, Cayton S, Abdulwali SK, Arai M, Sithu ID, Conklin DJ, Bolli R, Mohamed TMA. Abouleisa RRE, et al. Cardiovasc Res. 2024 Mar 13;120(2):152-163. doi: 10.1093/cvr/cvae002. Cardiovasc Res. 2024. PMID: 38175760
Our group recently showed that polycistronic non-integrating lentivirus encoding Cdk1/CyclinB1 and Cdk4/CyclinD1 (TNNT2-4Fpolycistronic-NIL) is effective in inducing CM cell cycle re-entry and ameliorating subacute IHF models and preventing the subsequent IHF-induced congestions …
Our group recently showed that polycistronic non-integrating lentivirus encoding Cdk1/CyclinB1 and Cdk4/CyclinD1 (TNNT2-4Fpolycistronic-NIL) …
Exercise-induced late preconditioning in mice is triggered by eNOS-dependent generation of nitric oxide and activation of PKCε and is mediated by increased iNOS activity.
Guo Y, Li Q, Xuan YT, Wu WJ, Tan W, Slezak J, Zhu X, Tomlin A, Bolli R. Guo Y, et al. Int J Cardiol. 2021 Oct 1;340:68-78. doi: 10.1016/j.ijcard.2021.08.021. Epub 2021 Aug 14. Int J Cardiol. 2021. PMID: 34400167 Free PMC article.
The purpose of this study was to assess whether short-term, mild exercise induces protection against myocardial infarction and, if so, what role the eNOS-PKCepsilon-iNOS axis plays. ...
The purpose of this study was to assess whether short-term, mild exercise induces protection against myocardial infarction and, if so …
Recommendations for nomenclature and definition of cell products intended for human cardiovascular use.
Taylor DA, Chacon-Alberty L, Sampaio LC, Hierro MGD, Perin EC, Mesquita FCP, Henry TD, Traverse JH, Pepine CJ, Hare JM, Murphy MP, Yang PC, March KL, Vojvodic RW, Ebert RF, Bolli R; Cardiovascular Cell Therapy Research Network (CCTRN). Taylor DA, et al. Cardiovasc Res. 2022 Aug 24;118(11):2428-2436. doi: 10.1093/cvr/cvab270. Cardiovasc Res. 2022. PMID: 34387303 Free PMC article.
However, the field of cell-based therapy is handicapped by the lack of standardized definitions and terminology, making comparisons across studies challenging. Even the term 'stem cell therapy' is misleading because only a small percentage of cells derived from adult bone …
However, the field of cell-based therapy is handicapped by the lack of standardized definitions and terminology, making comparisons across s …
Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction.
Dassanayaka S, Brittian KR, Long BW, Higgins LA, Bradley JA, Audam TN, Jurkovic A, Gumpert AM, Harrison LT, Hartyánszky I, Perge P, Merkely B, Radovits T, Hanover JA, Jones SP. Dassanayaka S, et al. PLoS One. 2020 Nov 30;15(11):e0242250. doi: 10.1371/journal.pone.0242250. eCollection 2020. PLoS One. 2020. PMID: 33253217 Free PMC article.
To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury. This observation has been repeated by multiple groups and in multiple models; however, whether increased protein O-GlcNAcylation plays a beneficial role …
To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury. This observa …
Meta-analysis of short- and long-term efficacy of mononuclear cell transplantation in patients with myocardial infarction.
Yang D, O'Brien CG, Ikeda G, Traverse JH, Taylor DA, Henry TD, Bolli R, Yang PC. Yang D, et al. Am Heart J. 2020 Feb;220:155-175. doi: 10.1016/j.ahj.2019.09.005. Epub 2019 Nov 11. Am Heart J. 2020. PMID: 31821904 Free PMC article.
Changes in the left ventricular end-systolic volume, left ventricular end-diastolic volume, brain natriuretic peptide/N-terminal pro-B-type natriuretic peptide, 6-minute walk test, New York Heart Association class, and MACE incidences were considered secondary outcomes. RESULTS: …
Changes in the left ventricular end-systolic volume, left ventricular end-diastolic volume, brain natriuretic peptide/N-terminal pro-B-type …
A realistic appraisal of the use of embryonic stem cell-based therapies for cardiac repair.
Wysoczynski M, Bolli R. Wysoczynski M, et al. Eur Heart J. 2020 Jul 1;41(25):2397-2404. doi: 10.1093/eurheartj/ehz787. Eur Heart J. 2020. PMID: 31778154 Free PMC article.
Although ESCs and ESC-derived cells were touted as capable of long-term regeneration, these cells disappear rapidly after transplantation and there is no evidence of long-term engraftment, let alone regeneration. ...
Although ESCs and ESC-derived cells were touted as capable of long-term regeneration, these cells disappear rapidly after transplanta …
Long-Term Outcome of Administration of c-kit(POS) Cardiac Progenitor Cells After Acute Myocardial Infarction: Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year.
Tang XL, Li Q, Rokosh G, Sanganalmath SK, Chen N, Ou Q, Stowers H, Hunt G, Bolli R. Tang XL, et al. Circ Res. 2016 Apr 1;118(7):1091-105. doi: 10.1161/CIRCRESAHA.115.307647. Epub 2016 Feb 2. Circ Res. 2016. PMID: 26838790 Free PMC article.
RATIONALE: Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. However, the long-term (>5 weeks) effects, potential tumorigenicity, and fate of transplanted CPCs are unknown. ...
RATIONALE: Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. Ho …
Remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure: critical importance of the cardiosplenic axis.
Ismahil MA, Hamid T, Bansal SS, Patel B, Kingery JR, Prabhu SD. Ismahil MA, et al. Circ Res. 2014 Jan 17;114(2):266-82. doi: 10.1161/CIRCRESAHA.113.301720. Epub 2013 Nov 1. Circ Res. 2014. PMID: 24186967 Free PMC article.
Splenocytes adoptively transferred from mice with HF, but not from sham-operated mice, homed to the heart and induced long-term left ventricular dilatation, dysfunction, and fibrosis in naive recipients. ...
Splenocytes adoptively transferred from mice with HF, but not from sham-operated mice, homed to the heart and induced long-term left …
Cardiomyocyte Ogt is essential for postnatal viability.
Watson LJ, Long BW, DeMartino AM, Brittian KR, Readnower RD, Brainard RE, Cummins TD, Annamalai L, Hill BG, Jones SP. Watson LJ, et al. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H142-53. doi: 10.1152/ajpheart.00438.2013. Epub 2013 Nov 1. Am J Physiol Heart Circ Physiol. 2014. PMID: 24186210 Free PMC article.
Additional groups of mice were subjected to inducible deletion of cmOGT, which did not produce overt dysfunction within the first couple of weeks of deletion. Yet, long-term loss (via inducible deletion) of cmOGT produced gradual and progressive cardiomyopathy. ...
Additional groups of mice were subjected to inducible deletion of cmOGT, which did not produce overt dysfunction within the first couple of …
Priming with ligands secreted by human stromal progenitor cells promotes grafts of cardiac stem/progenitor cells after myocardial infarction.
Iso Y, Rao KS, Poole CN, Zaman AK, Curril I, Sobel BE, Kajstura J, Anversa P, Spees JL. Iso Y, et al. Stem Cells. 2014 Mar;32(3):674-83. doi: 10.1002/stem.1546. Stem Cells. 2014. PMID: 24022988 Free PMC article.
Similar to CdM priming, priming of CSCs with CTGF-D4 and Insulin for 30 minutes prior to transplantation promoted robust engraftment, survival, and migration of CSC derivatives at 1 week and 1 month after MI. Our results indicate that short-term priming of human CSCs with …
Similar to CdM priming, priming of CSCs with CTGF-D4 and Insulin for 30 minutes prior to transplantation promoted robust engraftment, surviv …
18 results