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2001 2
2002 1
2004 1
2006 1
2024 0

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Page 1
Stem cell-derived erythroid cells mediate long-term systemic protein delivery.
Chang AH, Stephan MT, Sadelain M. Chang AH, et al. Nat Biotechnol. 2006 Aug;24(8):1017-21. doi: 10.1038/nbt1227. Epub 2006 Jul 16. Nat Biotechnol. 2006. PMID: 16845377
We demonstrate here the capacity of erythroid cells to mediate long-term, systemic and therapeutic protein delivery in vivo. By targeting human factor IX (hFIX) expression to late-stage erythropoiesis, we achieve long-term hFIX secretion at levels significantly high …
We demonstrate here the capacity of erythroid cells to mediate long-term, systemic and therapeutic protein delivery in vivo. By targe …
Elevated telomerase activity and minimal telomere loss in cord blood long-term cultures with extensive stem cell replication.
Gammaitoni L, Weisel KC, Gunetti M, Wu KD, Bruno S, Pinelli S, Bonati A, Aglietta M, Moore MA, Piacibello W. Gammaitoni L, et al. Blood. 2004 Jun 15;103(12):4440-8. doi: 10.1182/blood-2003-09-3079. Epub 2004 Jan 15. Blood. 2004. PMID: 14726371 Free article.
Telomerase activity, telomere length, stem/progenitor cell production, and function of CD34+ cells from cord blood (CB), bone marrow, and mobilized peripheral blood were evaluated in long-term cultures. CB cells were cultured either on OP-9 stromal cells transduced with an …
Telomerase activity, telomere length, stem/progenitor cell production, and function of CD34+ cells from cord blood (CB), bone marrow, and mo …
Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene.
May C, Rivella S, Chadburn A, Sadelain M. May C, et al. Blood. 2002 Mar 15;99(6):1902-8. doi: 10.1182/blood.v99.6.1902. Blood. 2002. PMID: 11877258 Free article.
A genetic treatment based on globin gene transfer would require that transgene expression be erythroid specific, elevated, and sustained over time. We report here that long-term synthesis of chimeric hemoglobin (mualpha(2):hubeta(A)(2)) could be achieved in mice with beta- …
A genetic treatment based on globin gene transfer would require that transgene expression be erythroid specific, elevated, and sustained ove …
A promising genetic approach to the treatment of beta-thalassemia.
May C, Sadelain M. May C, et al. Trends Cardiovasc Med. 2001 Oct;11(7):276-80. doi: 10.1016/s1050-1738(01)00125-6. Trends Cardiovasc Med. 2001. PMID: 11709281 Review.
Our results demonstrate that with thoughtful vector design one can successfully express long-term, therapeutic levels of virally encoded human beta-globin in the erythroid progeny of hematopoietic stem cells....
Our results demonstrate that with thoughtful vector design one can successfully express long-term, therapeutic levels of virally enco …
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells.
Hattori K, Heissig B, Tashiro K, Honjo T, Tateno M, Shieh JH, Hackett NR, Quitoriano MS, Crystal RG, Rafii S, Moore MA. Hattori K, et al. Blood. 2001 Jun 1;97(11):3354-60. doi: 10.1182/blood.v97.11.3354. Blood. 2001. PMID: 11369624 Free article.
In addition, AdSDF1 induced mobilization of cells with stem cell potential, including colony-forming units in spleen and long-term reconstituting cells. These data demonstrate that overexpression of SDF1 in the peripheral circulation results in the mobilization of hematopo …
In addition, AdSDF1 induced mobilization of cells with stem cell potential, including colony-forming units in spleen and long-term re …