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Potential Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis.
Lerche CJ, Schwartz F, Pries-Heje MM, Fosbøl EL, Iversen K, Jensen PØ, Høiby N, Hyldegaard O, Bundgaard H, Moser C. Lerche CJ, et al. Among authors: hoiby n. Front Cell Infect Microbiol. 2022 Feb 3;12:805964. doi: 10.3389/fcimb.2022.805964. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35186793 Free PMC article. Review.
New therapeutic options in IE are much needed and adjunctive HBOT might be a therapeutic option in certain IE patients to decrease morbidity and mortality and improve the long-term outcome of this severe disease....
New therapeutic options in IE are much needed and adjunctive HBOT might be a therapeutic option in certain IE patients to decrease morbidity …
Anti-biofilm Approach in Infective Endocarditis Exposes New Treatment Strategies for Improved Outcome.
Lerche CJ, Schwartz F, Theut M, Fosbøl EL, Iversen K, Bundgaard H, Høiby N, Moser C. Lerche CJ, et al. Among authors: hoiby n. Front Cell Dev Biol. 2021 Jun 18;9:643335. doi: 10.3389/fcell.2021.643335. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34222225 Free PMC article. Review.
From early on, in the antibiotic era, it was recognized that high-dose and long-term antibiotic therapy was correlated to improved outcome. In addition, for several of the common microbial IE etiologies, the use of combination antibiotic therapy further improves outcome. . …
From early on, in the antibiotic era, it was recognized that high-dose and long-term antibiotic therapy was correlated to improved ou …
Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen treatment in Pseudomonas aeruginosa PAO1 biofilms.
Gade PAV, Olsen TB, Jensen PØ, Kolpen M, Høiby N, Henneberg KÅ, Sams T. Gade PAV, et al. Among authors: hoiby n. PLoS One. 2018 Jun 14;13(6):e0198909. doi: 10.1371/journal.pone.0198909. eCollection 2018. PLoS One. 2018. PMID: 29902223 Free PMC article.
The complete oxygen model comprises a reaction-diffusion equation describing the oxygen consumption by using a Michaelis-Menten reaction term. The oxygen model performed well in predicting oxygen concentrations in both time and depth into the biofilm. At 2.8 bar pure oxyge …
The complete oxygen model comprises a reaction-diffusion equation describing the oxygen consumption by using a Michaelis-Menten reaction …
Chronic urinary tract infections in patients with spinal cord lesions - biofilm infection with need for long-term antibiotic treatment.
Tofte N, Nielsen AC, Trøstrup H, Andersen CB, Von Linstow M, Hansen B, Biering-Sørensen F, Høiby N, Moser C. Tofte N, et al. Among authors: hoiby n. APMIS. 2017 Apr;125(4):385-391. doi: 10.1111/apm.12685. APMIS. 2017. PMID: 28407430 Review.
Based on a previous study showing activation of humoral immune response toward UTI pathogens in patients with spinal cord lesions (SCL), the present mini review is an evaluation of using antibody response as an indicator of chronic biofilm UTI. In addition, we evaluated the effec …
Based on a previous study showing activation of humoral immune response toward UTI pathogens in patients with spinal cord lesions (SCL), the …
A short history of microbial biofilms and biofilm infections.
Høiby N. Høiby N. APMIS. 2017 Apr;125(4):272-275. doi: 10.1111/apm.12686. APMIS. 2017. PMID: 28407426 Review.
The concept of biofilm infections and their importance in medicine was, however, initiated in the early 1970s by the observation of heaps of Pseudomonas aeruginosa cells in sputum and lung tissue from chronically infected cystic fibrosis patients. The term biofilm was intr …
The concept of biofilm infections and their importance in medicine was, however, initiated in the early 1970s by the observation of heaps of …
The phenotypic evolution of Pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin.
Wassermann T, Meinike Jørgensen K, Ivanyshyn K, Bjarnsholt T, Khademi SMH, Jelsbak L, Høiby N, Ciofu O. Wassermann T, et al. Among authors: hoiby n. Microbiology (Reading). 2016 May;162(5):865-875. doi: 10.1099/mic.0.000273. Epub 2016 Mar 7. Microbiology (Reading). 2016. PMID: 26953154 Free article.
The immediate response of P. aeruginosa to subinhibitory concentrations of ciprofloxacin has been investigated previously. However, the long-term phenotypic adaptation, which identifies the fitted phenotypes that have been selected during evolution with subinhibitory conce …
The immediate response of P. aeruginosa to subinhibitory concentrations of ciprofloxacin has been investigated previously. However, the long …
The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection -- a pilot study.
Skov M, Pressler T, Lykkesfeldt J, Poulsen HE, Jensen PØ, Johansen HK, Qvist T, Kræmer D, Høiby N, Ciofu O. Skov M, et al. Among authors: hoiby n. J Cyst Fibros. 2015 Mar;14(2):211-8. doi: 10.1016/j.jcf.2014.09.015. Epub 2014 Oct 23. J Cyst Fibros. 2015. PMID: 25458464 Free article. Clinical Trial.
Environmental heterogeneity drives within-host diversification and evolution of Pseudomonas aeruginosa.
Markussen T, Marvig RL, Gómez-Lozano M, Aanæs K, Burleigh AE, Høiby N, Johansen HK, Molin S, Jelsbak L. Markussen T, et al. Among authors: hoiby n. mBio. 2014 Sep 16;5(5):e01592-14. doi: 10.1128/mBio.01592-14. mBio. 2014. PMID: 25227464 Free PMC article.
Microbial population polymorphisms are commonly observed in natural environments, including long-term infected hosts. However, the underlying processes promoting and stabilizing diversity are difficult to unravel and are not well understood. ...The results reveal a complex …
Microbial population polymorphisms are commonly observed in natural environments, including long-term infected hosts. However, the un …
A personal history of research on microbial biofilms and biofilm infections.
Høiby N. Høiby N. Pathog Dis. 2014 Apr;70(3):205-11. doi: 10.1111/2049-632X.12165. Pathog Dis. 2014. PMID: 24585728 Review.

The concept of biofilm infections and their importance in medicine is, however, < 40 years old and was started by Jendresen's observations of acquired dental pellicles and my own observations of heaps of Pseudomonas aeruginosa cells in sputum and lung tissue from chronically i

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The concept of biofilm infections and their importance in medicine is, however, < 40 years old and was started by Jendresen's observation

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Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa.
Jørgensen KM, Wassermann T, Jensen PØ, Hengzuang W, Molin S, Høiby N, Ciofu O. Jørgensen KM, et al. Among authors: hoiby n. Antimicrob Agents Chemother. 2013 Sep;57(9):4215-21. doi: 10.1128/AAC.00493-13. Epub 2013 Jun 17. Antimicrob Agents Chemother. 2013. PMID: 23774442 Free PMC article.
The dynamics of occurrence and the genetic basis of ciprofloxacin resistance were studied in a long-term evolution experiment (940 generations) in wild-type, reference strain (PAO1) and hypermutable (PAOdeltamutS and PAOMY-Mgm) P. aeruginosa populations continuously expose …
The dynamics of occurrence and the genetic basis of ciprofloxacin resistance were studied in a long-term evolution experiment (940 ge …
34 results