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A randomised controlled trial in preterm infants comparing prophylactic with selective "less invasive surfactant administration" (pro.LISA).
Göpel W, Rausch TK, Mitschdörfer B, Mader S, Herting E, König IR, Stichtenoth G; pro.LISA study group. Göpel W, et al. Trials. 2023 Sep 26;24(1):612. doi: 10.1186/s13063-023-07603-7. Trials. 2023. PMID: 37752593 Free PMC article. Clinical Trial.
Secondary endpoints include additional lung function parameters, endurance, motor development, intelligence, and sensitivity for infectious lung diseases. Short-term safety assessment will be done after completed enrolment (n = 698) and discharge of all infants. This safet …
Secondary endpoints include additional lung function parameters, endurance, motor development, intelligence, and sensitivity for infectious …
Increased Expression of Anaphylatoxin C5a-Receptor-1 in Neutrophils and Natural Killer Cells of Preterm Infants.
Boeckel H, Karsten CM, Göpel W, Herting E, Rupp J, Härtel C, Hartz A. Boeckel H, et al. Among authors: hartel c. Int J Mol Sci. 2023 Jun 19;24(12):10321. doi: 10.3390/ijms241210321. Int J Mol Sci. 2023. PMID: 37373467 Free PMC article.
Via flow cytometry, we analyzed the expression pattern of C5a receptors on immune cells isolated from peripheral blood of preterm infants (n = 32) compared to those of their mothers (n = 25). Term infants and healthy adults served as controls. Preterm infants had a higher …
Via flow cytometry, we analyzed the expression pattern of C5a receptors on immune cells isolated from peripheral blood of preterm infants (n …
First-Day-of-Life Rectal Swabs Fail To Represent Meconial Microbiota Composition and Underestimate the Presence of Antibiotic Resistance Genes.
Graspeuntner S, Lupatsii M, Dashdorj L, Rody A, Rupp J, Bossung V, Härtel C. Graspeuntner S, et al. Among authors: hartel c. Microbiol Spectr. 2023 Jun 15;11(3):e0525422. doi: 10.1128/spectrum.05254-22. Epub 2023 Apr 25. Microbiol Spectr. 2023. PMID: 37097170 Free PMC article.
We have put together our knowledge on this critical aspect with careful consideration and identified the failure of rectal swabs to be a replacement for sampling of meconium in term-born newborns....
We have put together our knowledge on this critical aspect with careful consideration and identified the failure of rectal swabs to be a rep …
Ontogenesis of functional platelet subpopulations from preterm and term neonates to adulthood: The PLINIUS study.
Weiss LJ, Drayss M, Mott K, Beck S, Unsin D, Just B, Speer CP, Härtel C, Andres O, Schulze H. Weiss LJ, et al. Among authors: hartel c. Blood Adv. 2023 Aug 22;7(16):4334-4348. doi: 10.1182/bloodadvances.2023009824. Blood Adv. 2023. PMID: 37042931 Free PMC article.
We recruited 64 subjects comprising 7 extremely preterm (27-31 weeks gestational age), 25 moderately preterm (32-36 weeks), 10 term neonates, 8 infants (<2 years), 5 children (2-13 years), and 9 adults (>13 years). Blood was withdrawn at up to 3 different time points …
We recruited 64 subjects comprising 7 extremely preterm (27-31 weeks gestational age), 25 moderately preterm (32-36 weeks), 10 term n …
The Delicate Skin of Preterm Infants: Barrier Function, Immune-Microbiome Interaction, and Clinical Implications.
Marissen J, Gomez de Agüero M, Chandorkar P, Reichert L, Glaser K, Speer CP, Härtel C. Marissen J, et al. Among authors: hartel c. Neonatology. 2023;120(3):295-307. doi: 10.1159/000529026. Epub 2023 Mar 17. Neonatology. 2023. PMID: 36934717 Free article. Review.
The skin of preterm infants is a delicate organ with critical structural and functional differences as compared to term born infants. Unique features contribute to an increased susceptibility to injury, infection, thermal instability, and water loss. ...
The skin of preterm infants is a delicate organ with critical structural and functional differences as compared to term born infants. …
Antimicrobial skin peptides in premature infants: Comparison with term infants and impact of perinatal factors.
Humberg A, Neuenburg L, Boeckel H, Fortmann MI, Härtel C, Herting E, Hinrichs H, Rademacher F, Harder J. Humberg A, et al. Among authors: hartel c. Front Immunol. 2023 Feb 27;14:1093340. doi: 10.3389/fimmu.2023.1093340. eCollection 2023. Front Immunol. 2023. PMID: 36923410 Free PMC article.

Samples were taken from preterm infants < 34 0/7 weeks gestational age (mean SD gestational age, 28.8 2.4 weeks) on days 0, 7, 14, and 28 after birth. Term infants (> 36 6/7 weeks) (controls) were washed on days 0 and 28. ...RNase 7 was more expressed in te

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Samples were taken from preterm infants < 34 0/7 weeks gestational age (mean SD gestational age, 28.8 2.4 weeks) on days 0, 7, 14, and 28

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Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14(+)CD16(+) Subset upon Toll-like Receptor Stimulation.
Glaser K, Kern D, Speer CP, Schlegel N, Schwab M, Thome UH, Härtel C, Wright CJ. Glaser K, et al. Among authors: hartel c. Int J Mol Sci. 2023 Mar 3;24(5):4919. doi: 10.3390/ijms24054919. Int J Mol Sci. 2023. PMID: 36902350 Free PMC article.
Developmentally regulated features of innate immunity are thought to place preterm and term infants at risk of infection and inflammation-related morbidity. ...Our data demonstrate robust pro-inflammatory and yet attenuated anti-inflammatory responses in preterm and ter …
Developmentally regulated features of innate immunity are thought to place preterm and term infants at risk of infection and inflamma …
Recurrent Late-Onset Sepsis in Extremely Low Birth Weight Infants Is Associated with Motor Deficits in Early School Age.
Humberg A, Fortmann MI, Spiegler J, Rausch TK, Siller B, Silwedel C, Marissen J, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN). Humberg A, et al. Among authors: hartel c. Neonatology. 2022;119(6):695-702. doi: 10.1159/000525709. Epub 2022 Nov 3. Neonatology. 2022. PMID: 36327925
INTRODUCTION: Sepsis is regarded as a risk factor for brain injury in preterm infants. We herein hypothesize that extremely low birth weight infants (ELBWI, birth weight <1,000 g) having survived recurrent blood culture-proven late-onset sepsis (LOS) episodes are …
INTRODUCTION: Sepsis is regarded as a risk factor for brain injury in preterm infants. We herein hypothesize that extremely low birth …
Acceptance of Different Self-sampling Methods for Semiweekly SARS-CoV-2 Testing in Asymptomatic Children and Childcare Workers at German Day Care Centers: A Nonrandomized Controlled Trial.
Engels G, Forster J, Streng A, Rücker V, Rudolph P, Pietsch F, Wallstabe J, Wallstabe L, Krauthausen M, Schmidt J, Ludwig T, Bauer C, Gierszewski D, Bendig J, Timme S, Jans T, Weißbrich B, Romanos M, Dölken L, Heuschmann P, Härtel C, Gágyor I, Figge MT, Liese J, Kurzai O; Wue-KiTa-CoV 2.0-Study Group. Engels G, et al. Among authors: hartel c. JAMA Netw Open. 2022 Sep 1;5(9):e2231798. doi: 10.1001/jamanetworkopen.2022.31798. JAMA Netw Open. 2022. PMID: 36107424 Free PMC article. Clinical Trial.
MAIN OUTCOMES AND MEASURES: Main outcomes were rates for initial acceptance and successful (60% of scheduled samples) long-term participation. The probability of SARS-CoV-2 introduction into DCCs was modeled as a function of age-adjusted background incidence and DCC size. …
MAIN OUTCOMES AND MEASURES: Main outcomes were rates for initial acceptance and successful (60% of scheduled samples) long-term parti …
Sleep problems in infancy and early school age in very preterm infants.
Neitmann J, Hanke K, Humberg A, Siller B, Spiegler J, Juhnke K, Gilmore J, Odendahl R, Herting E, Göpel W, Härtel C, Fortmann I; German Neonatal Network (GNN). Neitmann J, et al. Among authors: hartel c. Early Hum Dev. 2022 Oct;173:105656. doi: 10.1016/j.earlhumdev.2022.105656. Epub 2022 Aug 15. Early Hum Dev. 2022. PMID: 35987047
BACKGROUND: Sleep plays an important role for psychological and physical health, especially in infants at high risk for long-term neurodevelopmental impairment such as preterm infants. OBJECTIVE: Our study aimed at determining risk factors for long-term sleep impair …
BACKGROUND: Sleep plays an important role for psychological and physical health, especially in infants at high risk for long-term neu …
66 results