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Prognosis of older patients with newly diagnosed AML undergoing antileukemic therapy: A systematic review.
Hao Q, Foroutan F, Han MA, Devji T, Nampo FK, Mukherjee S, Alibhai SMH, Rosko A, Sekeres MA, Guyatt GH, Brignardello-Petersen R. Hao Q, et al. Among authors: guyatt gh. PLoS One. 2022 Dec 5;17(12):e0278578. doi: 10.1371/journal.pone.0278578. eCollection 2022. PLoS One. 2022. PMID: 36469519 Free PMC article.
Meta-analysis showed that age (per 5-year increase, HR 1.16 95% CI 1.11-1.21, high-quality evidence), comorbidities (Hematopoietic Cell Transplantation-specific Comorbidity Index: 3+ VS less than 3, HR 1.60 95% CI 1.31-1.95, high-quality evidence), and performance status (Eastern …
Meta-analysis showed that age (per 5-year increase, HR 1.16 95% CI 1.11-1.21, high-quality evidence), comorbidities (Hematopoietic Cell Tran …
Association of Patient-Level and Hospital-Level Factors With Timely Fracture Care by Race.
Gitajn IL, Werth P, Fernandes E, Sprague S, O'Hara NN, Bzovsky S, Marchand LS, Patterson JT, Lee C, Slobogean GP; PREP-IT Investigators. Gitajn IL, et al. JAMA Netw Open. 2022 Nov 1;5(11):e2244357. doi: 10.1001/jamanetworkopen.2022.44357. JAMA Netw Open. 2022. PMID: 36449289 Free PMC article.
After controlling for patient-level characteristics, there was an independent association between missing the 24-hour benchmark and hospital population insurance coverage (OR, 0.94; 95% CI, 0.89-0.98; P = .005) and the interaction term between hospital population insurance …
After controlling for patient-level characteristics, there was an independent association between missing the 24-hour benchmark and hospital …
Hypoparathyroidism: Genetics and Diagnosis.
Mannstadt M, Cianferotti L, Gafni RI, Giusti F, Kemp EH, Koch CA, Roszko KL, Yao L, Guyatt GH, Thakker RV, Xia W, Brandi ML. Mannstadt M, et al. Among authors: guyatt gh. J Bone Miner Res. 2022 Dec;37(12):2615-2629. doi: 10.1002/jbmr.4667. Epub 2022 Nov 14. J Bone Miner Res. 2022. PMID: 36375809 Free article.
We also undertook a systematic review addressing the utility of measuring calcium and PTH within 24 hours after total thyroidectomy to predict long-term hypoparathyroidism. A summary of the findings is presented here; results of the detailed systematic review are published …
We also undertook a systematic review addressing the utility of measuring calcium and PTH within 24 hours after total thyroidectomy to predi …
Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial.
Nevalainen OPO, Horstia S, Laakkonen S, Rutanen J, Mustonen JMJ, Kalliala IEJ, Ansakorpi H, Kreivi HR, Kuutti P, Paajanen J, Parkkila S, Paukkeri EL, Perola M, Pourjamal N, Renner A, Rosberg T, Rutanen T, Savolainen J; Solidarity Finland Investigators; Haukka JK, Guyatt GH, Tikkinen KAO. Nevalainen OPO, et al. Among authors: guyatt gh. Nat Commun. 2022 Oct 18;13(1):6152. doi: 10.1038/s41467-022-33825-5. Nat Commun. 2022. PMID: 36257950 Free PMC article.
We report the first long-term follow-up of a randomized trial (NCT04978259) addressing the effects of remdesivir on recovery (primary outcome) and other patient-important outcomes one year after hospitalization resulting from COVID-19. ...
We report the first long-term follow-up of a randomized trial (NCT04978259) addressing the effects of remdesivir on recovery (primary …
Evaluation and Management of Hypoparathyroidism Summary Statement and Guidelines from the Second International Workshop.
Khan AA, Bilezikian JP, Brandi ML, Clarke BL, Gittoes NJ, Pasieka JL, Rejnmark L, Shoback DM, Potts JT, Guyatt GH, Mannstadt M. Khan AA, et al. Among authors: guyatt gh. J Bone Miner Res. 2022 Dec;37(12):2568-2585. doi: 10.1002/jbmr.4691. Epub 2022 Nov 14. J Bone Miner Res. 2022. PMID: 36054621 Free article.
To predict which patients will not develop permanent postsurgical HypoPT, we recommend evaluating serum PTH within 12 to 24 hours post total thyroidectomy (strong recommendation, moderate quality evidence). PTH > 10 pg/mL (1.05 pmol/L) virtually excludes long-term HypoP …
To predict which patients will not develop permanent postsurgical HypoPT, we recommend evaluating serum PTH within 12 to 24 hours post total …
Prophylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials.
Dayyani M, Sadeghirad B, Grotta JC, Zabihyan S, Ahmadvand S, Wang Y, Guyatt GH, Amin-Hanjani S. Dayyani M, et al. Among authors: guyatt gh. Stroke. 2022 Jun;53(6):1993-2005. doi: 10.1161/STROKEAHA.121.035699. Epub 2022 Mar 31. Stroke. 2022. PMID: 35354302
Future trials are warranted to elaborately investigate the prophylactic effects of medications that may improve mortality and long-term functional outcomes, such as cilostazol and clazosentan. REGISTRATION: URL: https://www.crd.york.ac.uk/PROSPERO/; Unique identifier: CRD4 …
Future trials are warranted to elaborately investigate the prophylactic effects of medications that may improve mortality and long-term …
What Factors Increase Revision Surgery Risk When Treating Displaced Femoral Neck Fractures With Arthroplasty: A Secondary Analysis of the HEALTH Trial.
Blankstein M, Schemitsch EH, Bzovsky S, Poolman RW, Frihagen F, Axelrod D, Heels-Ansdell D, Bhandari M, Sprague S, Schottel PC; HEALTH Investigators. Blankstein M, et al. J Orthop Trauma. 2020 Nov;34 Suppl 3:S49-S54. doi: 10.1097/BOT.0000000000001936. J Orthop Trauma. 2020. PMID: 33027166 Clinical Trial.
OBJECTIVES: HEALTH was a randomized controlled trial comparing total hip arthroplasty with hemiarthroplasty in low-energy displaced femoral neck fracture patients aged 50 years with unplanned revision surgery within 24 months of the initial procedure being the primary outcome. No …
OBJECTIVES: HEALTH was a randomized controlled trial comparing total hip arthroplasty with hemiarthroplasty in low-energy displaced femoral …
Discrepancies Between Patient and Surgeon Expectations of Surgery for Sciatica: A Challenge for Informed Decision Making?
Rehman Y, Syed M, Wiercioch W, Rehman N, Drew B, Cenic A, Reddy K, Murty N, Kucher E, Dunlop B, Guyatt GH, Busse JW, Schwartz L, Vanstone M. Rehman Y, et al. Among authors: guyatt gh. Spine (Phila Pa 1976). 2019 May 15;44(10):740-746. doi: 10.1097/BRS.0000000000002914. Spine (Phila Pa 1976). 2019. PMID: 30395083
Surgeons and patients disagreed on how much information is needed about postsurgical activity modifications and long-term outcomes to make a decision about whether or not to undergo surgery, with patients desiring more information. ...
Surgeons and patients disagreed on how much information is needed about postsurgical activity modifications and long-term outcomes to …
Long-term risks of stress and urgency urinary incontinence after different vaginal delivery modes.
Tähtinen RM, Cartwright R, Vernooij RWM, Rortveit G, Hunskaar S, Guyatt GH, Tikkinen KAO. Tähtinen RM, et al. Among authors: guyatt gh. Am J Obstet Gynecol. 2019 Feb;220(2):181.e1-181.e8. doi: 10.1016/j.ajog.2018.10.034. Epub 2018 Nov 1. Am J Obstet Gynecol. 2019. PMID: 30391444
with response options yes or no. Incontinence data were linked to the Medical Birth Registry of Norway. For this study, we included only women who had a history of vaginal birth(s). ...CONCLUSION: For women aged younger than 50 years, forceps delivery is associated …
with response options yes or no. Incontinence data were linked to the Medical Birth Registry of Norway. For this study, we included o …
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