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Role of Tyrosine Nitrosylation in Stress-Induced Major Depressive Disorder: Mechanisms and Implications.
Wilson GC, Keitsch S, Soddemann M, Wilker B, Edwards MJ, Gulbins E. Wilson GC, et al. Among authors: gulbins e. Int J Mol Sci. 2023 Sep 27;24(19):14626. doi: 10.3390/ijms241914626. Int J Mol Sci. 2023. PMID: 37834072 Free PMC article.
We show that glucocorticoid- and chronic unpredictable environmental stress induced tyrosine nitrosylation in the hippocampus. Long-term treatment of stressed mice with the classical antidepressants amitriptyline or fluoxetine prevented tyrosine nitrosylation. ...
We show that glucocorticoid- and chronic unpredictable environmental stress induced tyrosine nitrosylation in the hippocampus. Long-term …
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma.
Wilson GC, Patel SH, Wang J, Xu K, Turner KM, Becker KA, Carpinteiro A, Szabo I, Ahmad SA, Gulbins E. Wilson GC, et al. Among authors: gulbins e. J Mol Med (Berl). 2023 Jul;101(7):891-903. doi: 10.1007/s00109-023-02331-6. Epub 2023 May 29. J Mol Med (Berl). 2023. PMID: 37246980 Free PMC article.
Here, we demonstrate that high expression of acid sphingomyelinase in PDAC strongly correlates with long-term survival of patients, as revealed by the analysis of two independent data sources. The positive effects of acid sphingomyelinase expression on long-term sur …
Here, we demonstrate that high expression of acid sphingomyelinase in PDAC strongly correlates with long-term survival of patients, a …
Doxycycline-Coated Silicone Breast Implants Reduce Acute Surgical-Site Infection and Inflammation.
Baker JE, Seitz AP, Boudreau RM, Skinner MJ, Beydoun A, Kaval N, Caldwell CC, Gulbins E, Edwards MJ, Gobble RM. Baker JE, et al. Among authors: gulbins e. Plast Reconstr Surg. 2020 Nov;146(5):1029-1041. doi: 10.1097/PRS.0000000000007277. Plast Reconstr Surg. 2020. PMID: 33141530
The authors' doxycycline-coated silicone implants significantly reduced biofilm formation, surgical-site infections, and inflammation. Further studies are needed to evaluate the long-term implications....
The authors' doxycycline-coated silicone implants significantly reduced biofilm formation, surgical-site infections, and inflammation. Furth …
Neutral Sphingomyelinase is an Affective Valence-Dependent Regulator of Learning and Memory.
Kalinichenko LS, Abdel-Hafiz L, Wang AL, Mühle C, Rösel N, Schumacher F, Kleuser B, Smaga I, Frankowska M, Filip M, Schaller G, Richter-Schmidinger T, Lenz B, Gulbins E, Kornhuber J, Oliveira AWC, Barros M, Huston JP, Müller CP. Kalinichenko LS, et al. Among authors: gulbins e. Cereb Cortex. 2021 Jan 5;31(2):1316-1333. doi: 10.1093/cercor/bhaa298. Cereb Cortex. 2021. PMID: 33043975
We found an association between superior performance in short- and long-term appetitively motivated learning and regionally enhanced neutral sphingomyelinase (NSM) activity. ...In a translational approach, we confirmed a positive association of serum NSM activity with long …
We found an association between superior performance in short- and long-term appetitively motivated learning and regionally enhanced …
Neutral ceramidase is a marker for cognitive performance in rats and monkeys.
Kalinichenko LS, Wang AL, Mühle C, Abdel-Hafiz L, Gulbins E, Kornhuber J, Oliveira AWC, Barros M, Huston JP, Müller CP. Kalinichenko LS, et al. Among authors: gulbins e. Pharmacol Rep. 2021 Feb;73(1):73-84. doi: 10.1007/s43440-020-00159-2. Epub 2020 Sep 16. Pharmacol Rep. 2021. PMID: 32936422 Free PMC article.
RESULTS: We observed a predictive role of NC activity in the blood serum for superior performance of long-term object memory tasks in both species. A brain area analysis suggested that high NC activity in the ventral mesencephalon (VM) predicts better short-term mem …
RESULTS: We observed a predictive role of NC activity in the blood serum for superior performance of long-term object memory tasks in …
Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro.
Naser E, Kadow S, Schumacher F, Mohamed ZH, Kappe C, Hessler G, Pollmeier B, Kleuser B, Arenz C, Becker KA, Gulbins E, Carpinteiro A. Naser E, et al. Among authors: gulbins e. J Lipid Res. 2020 Jun;61(6):896-910. doi: 10.1194/jlr.RA120000682. Epub 2020 Mar 10. J Lipid Res. 2020. PMID: 32156719 Free PMC article.
When applied intraperitoneally in vivo, even subtoxic high doses administered short-term induced sphingomyelin accumulation only locally in the peritoneal lavage without significant accumulation in plasma, liver, spleen, or brain. ...
When applied intraperitoneally in vivo, even subtoxic high doses administered short-term induced sphingomyelin accumulation only loca …
Acid Sphingomyelinase Inhibition Mitigates Histopathological and Behavioral Changes in a Murine Model of Traumatic Brain Injury.
Niziolek GM, Boudreau RM, Baker J, Friend LA, Makley AT, Edwards MJ, Gulbins E, Goodman MD. Niziolek GM, et al. Among authors: gulbins e. J Neurotrauma. 2020 Sep 1;37(17):1902-1909. doi: 10.1089/neu.2019.6436. Epub 2020 May 4. J Neurotrauma. 2020. PMID: 32138594 Free PMC article.
These findings highlight an opportunity to potentially reduce the long-term consequences of TBI....
These findings highlight an opportunity to potentially reduce the long-term consequences of TBI....
Regulation of Arthritis Severity by the Acid Sphingomyelinase.
Beckmann N, Becker KA, Walter S, Becker JU, Kramer M, Hessler G, Weber S, Göthert JR, Fassbender K, Gulbins E, Carpinteiro A. Beckmann N, et al. Among authors: gulbins e. Cell Physiol Biochem. 2017;43(4):1460-1471. doi: 10.1159/000481968. Epub 2017 Oct 16. Cell Physiol Biochem. 2017. PMID: 29035882 Free article.
Functional inhibitors of acid sphingomyelinase have been clinically used for decades, are well tolerated and suitable for long-term treatment. They would be immediately available for clinical development as a novel rheumatoid arthritis therapy....
Functional inhibitors of acid sphingomyelinase have been clinically used for decades, are well tolerated and suitable for long-term t …
Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline.
Adams C, Icheva V, Deppisch C, Lauer J, Herrmann G, Graepler-Mainka U, Heyder S, Gulbins E, Riethmueller J. Adams C, et al. Among authors: gulbins e. Cell Physiol Biochem. 2016;39(2):565-72. doi: 10.1159/000445648. Epub 2016 Jul 11. Cell Physiol Biochem. 2016. PMID: 27395380 Free article.
Sex-dependent decrease of sphingomyelinase activity during alcohol withdrawal treatment.
Mühle C, Amova V, Biermann T, Bayerlein K, Richter-Schmidinger T, Kraus T, Reichel M, Gulbins E, Kornhuber J. Mühle C, et al. Among authors: gulbins e. Cell Physiol Biochem. 2014;34(1):71-81. doi: 10.1159/000362985. Epub 2014 Jun 16. Cell Physiol Biochem. 2014. PMID: 24977482 Free article.
METHODS: Here, we analyzed the time course of ASM in male and also female acutely intoxicated patients during alcohol withdrawal and compared the activity levels to those under long-term maintenance treatment. Craving and further psychometric parameters were assessed by qu …
METHODS: Here, we analyzed the time course of ASM in male and also female acutely intoxicated patients during alcohol withdrawal and compare …
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