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STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription.
Schober R, Waldherr L, Schmidt T, Graziani A, Stilianu C, Legat L, Groschner K, Schindl R. Schober R, et al. Among authors: groschner k. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1079-1091. doi: 10.1016/j.bbamcr.2018.11.001. Epub 2018 Nov 6. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30408546 Free article. Review.
These induced Ca(2+) microdomains are tailored to, and sufficient for, triggering long-term activation processes, such as transcription factor activation and subsequent gene regulation. ...
These induced Ca(2+) microdomains are tailored to, and sufficient for, triggering long-term activation processes, such as transcripti …
Nanopatterned polymer substrates promote endothelial proliferation by initiation of β-catenin transcriptional signaling.
Schernthaner M, Reisinger B, Wolinski H, Kohlwein SD, Trantina-Yates A, Fahrner M, Romanin C, Itani H, Stifter D, Leitinger G, Groschner K, Heitz J. Schernthaner M, et al. Among authors: groschner k. Acta Biomater. 2012 Aug;8(8):2953-62. doi: 10.1016/j.actbio.2012.04.018. Epub 2012 Apr 20. Acta Biomater. 2012. PMID: 22522133
Analysis of cell phenotype markers as well as beta-catenin signaling revealed that short-term culture of endothelial cells on nanostructured substrates generates a proliferative cell phenotype associated with nuclear accumulation of beta-catenin and activation of specific …
Analysis of cell phenotype markers as well as beta-catenin signaling revealed that short-term culture of endothelial cells on nanostr …
Role of TRP channels in oxidative stress.
Groschner K, Rosker C, Lukas M. Groschner K, et al. Novartis Found Symp. 2004;258:222-30; discussion 231-5, 263-6. Novartis Found Symp. 2004. PMID: 15104185
A typical target of ROS/RNS signalling is Ca2+ channels which mediate both long-term as well as acute cellular responses to oxidative stress. We have previously reported that cation channels related to the Drosophila transient receptor potential gene product (TRPC proteins …
A typical target of ROS/RNS signalling is Ca2+ channels which mediate both long-term as well as acute cellular responses to oxidative …
Two ways to feel the pressure: an endothelial Ca(2+) entry channel with dual mechanosensitivity.
Groschner K. Groschner K. Cardiovasc Res. 2002 Jan;53(1):9-11. doi: 10.1016/s0008-6363(01)00519-3. Cardiovasc Res. 2002. PMID: 11744009 Review.
Besides this fast feedback response to hemodynamic alterations, the endothelium is subject to long-term adaptations that are crucial for prevention of pathological processes such as atherogenesis. Among the various signals that are sensed by endothelial cells, mechanical f …
Besides this fast feedback response to hemodynamic alterations, the endothelium is subject to long-term adaptations that are crucial …